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Mast cells reduce survival of myenteric neurons in culture.

Mast cell-nerve interactions play a key role in intestinal inflammation and irritable bowel disease. Loss of enteric neurons has been reported in inflammatory conditions but the contribution of mast cells in this event is unknown. To study neuronal survival and plasticity of myenteric neurons in contact with mast cells a co-culture system using myenteric neurons from rat small intestine and perito

Everyday experience of families three years after diagnosis of type 1 diabetes in children: a research paper.

The purpose of this study was to illuminate the everyday experience of family members 3 years after a child had been diagnosed as having Type 1 diabetes. Qualitative interviews were conducted with 35 family members in 11 families and analyzed using a content analysis. The results were identified as eight categories describing the family member's everyday experiences: (a) knowledge and tried experi

Explaining Modes of Participation. A Dynamic Test of Alternative Rational Choice Models

Rational choice accounts of political participation identify two major solutions to “the paradox of participation” — collective incentives and selective incentives. Prior findings regarding the viability of these solutions are seemingly inconclusive and contradictory. In our view, one important reason for this is that the applicability of these solutions varies across participatory modes. In this

Pressure transduction to the thoracic cavity during topical negative pressure therapy of a sternotomy wound.

The present study was performed to examine pressure transduction to the thoracic cavity during topical negative pressure (TNP) therapy of a sternotomy wound. Seven pigs underwent median sternotomy. Pressure transduction catheters were placed on the anterior surface of the heart (under the foam), in the pericardium (under the heart), in the left pleura and in the oesophagus at the level of the hear

On a first-order stochastic differential equation

A first-order system with random parameters and random forcing is studied. The analysis is concentrated on the probability distributions. It is shown that considerable qualitative information can be obtained from Feller's classification of the singular points of the forward and backward Kolmogorov equations. It is found that there is a drastic difference between the cases of uncorrelated and stron

Relation between cardiac dimensions and peak oxygen uptake.

ABSTRACT: BACKGROUND: Long term endurance training is known to increase peak oxygen uptake () and induce morphological changes of the heart such as increased left ventricular mass (LVM). However, the relationship between and the total heart volume (THV), considering both the left and right ventricular dimensions in both males and females, is not completely described. Therefore, the aim of this stu

A scattering and absorption identity for metamaterials: experimental results and comparison with theory

A dispersion relation for the combined effect of scattering and absorption of electromagnetic waves is presented for a large class of linear and passive material models. By invoking the optical theorem, the result states that the extinction cross section integrated over all frequencies is equal to the static limit of the extinction volume. The present paper focuses on an attempt to experimentally

Indications for first caesarean and delivery mode in subsequent trial of labour.

A previous caesarean delivery is no longer an indication per se for a subsequent, planned caesarean. We performed this study to identify women suitable for trial of labour after caesarean (TOLAC), investigating the association between the indication for the first caesarean and the risk of unplanned caesarean in the second pregnancy.

In the light of the province: Carl Slättne and his films

This article presents the work of Swedish film-maker and independent producer Carl Slättne (b. 1937) and analyses his film Urskogen eller kulturen!/‘Wilderness or Civilization!’ (1985). The film is discussed in relation to the concept of the essay film as it has been developed in recent writings by Laura Rascaroli and Timothy Corrigan. The formal devices of Slättne’s film are analysed and put into

The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.

ABSTRACT: For a long time, genetic studies of complex diseases were most successfully conducted in animal models. However, the field of genetics is now rapidly evolving, and human genetics has also started to produce strong candidate genes for complex diseases. This raises the question of how to continue gene-finding attempts in animals and how to use animal models to enhance our understanding of

Impaired nerve-mediated relaxation of penile tissue from caveolin-1 deficient mice.

Caveolin-1-deficient mice are characterised by a high vascular NO production. Because NO-dependent smooth muscle relaxation is considered to play an important role in penile erection, it was hypothesized that the erectile function would be affected by genetic ablation of caveolae. This study assessed penile erectile mechanisms in caveolin-1 knockout (KO) mice ex vivo. Immunofluorescence confirmed

Incidence of alcoholism in the revisited Lundby population, 1947-1997.

OBJECTIVE: The Lundby Study is a prospective longitudinal study of an unselected population consisting of 3,563 subjects. The Lundby Study started in 1947, and follow-ups were carried out in 1957, 1972, and in 1997. METHOD: In all four surveys, semistructured interviews were performed by psychiatrists. Registers, key informants, and case notes from hospitals and outpatient clinics supplemented the

Empirical Bayes and semi-Bayes adjustments for a vast number of estimations.

Investigators in modern molecular/genetic epidemiology studies commonly analyze data on a vast number of candidate genetic markers. In such situations, rather than conventional estimation of effects (odds ratios), more accurate estimation methods are needed. The author proposes consideration of empirical Bayes and semi-Bayes methods, which yield 'adjustments for multiple estimations' by shrinking

Evidence Supporting a Key Role of Lp-PLA2-Generated Lysophosphatidylcholine in Human Atherosclerotic Plaque Inflammation.

OBJECTIVE: To determine whether the level of lysophosphatidylcholine (lysoPC) generated by lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with severity of inflammation in human atherosclerotic plaques. Elevated plasma Lp-PLA2 is associated with increased cardiovascular risk. Lp-PLA2 inhibition reduces atherosclerosis. Lp-PLA2 hydrolyzes low-density lipoprotein-oxidized phospholipi