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BACKGROUND: Wolff-Parkinson-White (WPW) syndrome is a rare cardiac disorder that predispose to supraventricular arrhythmias. Prognosis is usually benign, yet there is an increased lifetime risk of sudden death. While typically sporadic, familial clustering has been reported. This study aimed to assess the risk of WPW, arrhythmias, and mortality among siblings of individuals with WPW.METHODS: This
OBJECTIVES: Ultra-high dose rate irradiation (UHDR) has been shown to spare normal tissue in various model systems. This study evaluates its potential to sterilize cancer cells using spheroid tumor models.METHODS: Spheroids from glioblastoma (U87), hypopharyngeal squamous cell carcinoma (two sizes, FaDusmall and FaDularge) and breast adenocarcinoma (T47D) cells were irradiated with electron beams
Small independent (indie) game startups face fierce competition when developing games with limited time, budget, and resources. Continuously testing and experimenting with new ideas, features, and content is essential to validate and guide development toward a viable and successful game. Such continuous experimentation (CE) requires access to users and user data, which is often very limited in the
We explore vibe coding as a rapid prototyping approach powered by generative AI. We discuss how it lowers the barrier to creating high-fidelity prototypes, enabling nontechnical users to build apps, and examine its implications for communication, validation, and iterative software design.
The onset of jet quenching, i.e. the suppression of high transverse momentum particles and jets, is an important question in the context of understanding the onset of collective behaviour and small collision systems. We investigate a minimal scenario where a hard parton experiences a single soft re-scattering that leaves the kinematics unmodified, but the colour exchange leads to a loss of colour
The rise of livestreaming as a promotional tool has increasingly attracted scholars to focus on the impact of livestreaming on tourism destination marketing and tourists' psychology, including perception. This study examines the effect of informativeness and interactivity on tourist flow, inspiration, and travel intention in travel livestreaming. Through 344 valid survey-based data, this study emp
Investigating respiratory fluxes is decisive for understanding the complex interplay between metabolic processes. Studies of cells and tissues with limited sample availability and low respiratory rates may benefit from small experimental volumes. We examined if the 0.5-mL chamber yields results consistent with the 2.0-mL chamber at identical sample concentrations used in high-resolution respiromet
SUMMARY: Craniopharyngiomas (CPs) are rare brain epithelial tumours arising in the suprasellar region, infiltrating adjacent areas causing visual loss, panhypopituitarism, cognitive deficits and morbid obesity. Papillary CPs (PCPs) harbour in 94% BRAF mutation cases. Two patients with PCP and BRAF V600E mutations but with different tumour status were treated with BRAF and MEK inhibitors. Case I wa
Protein deletions are frequent among both natural and pathogenic variations. Many of them are misclassified in variation databases and the literature. Nonsense-mediated decay prevents the expression of many nucleotide deletions. Many variants classified as protein deletions are not expressed at all. We conducted an exhaustive systematic analysis of three types of deletions: N- and C-terminal delet
Background: Although optical coherence tomography (OCT) has become essential in pediatric ophthalmology, normative data for children are lacking in most device databases. Due to ongoing ocular growth and developmental changes that occur during childhood and adolescence, adult reference values are not appropriate for pediatric use. Additionally, OCT measurements vary across devices, indicating the
In this paper, a new Monte Carlo Glauber model is developed for pA collisions. It uses the hadronic cross sections calculated within the KMR model as implemented in the SHRiMPS minimum bias module of the SHERPA event generator. These cross sections are obtained as functions of impact parameter and, therefore, are ready for use in a Glauber model without additional assumptions regarding their impac
BackgroundWhile physical activity is known to affect the risk of MAFLD in adults, evidence in adolescents is limited and often based on self-reported questionnaires. We therefore used wearable device–based measurements to investigate the association between physical activity and MAFLD in adolescents.MethodsData were obtained from the National Health and Nutrition Examination Survey (NHANES) databa
The Amazonian Craton is host to one of Earth’s largest Proterozoic silicic large igneous provinces (SLIPs), the Orocaima SLIP (ca. 1.98 Ga). Nevertheless, the mechanism(s) responsible for this large-flux felsic magmatic event and its relationships with regional tectonics and/or mantle processes remain debated. New geochronologic and geochemical results from multiple mafic dike swarms in the Amazon
The consideration of patient experiences has gained significant attention in recent years as part of the broader shift toward patient-centered care. The aim of this chapter is to explore the personal experiences of individuals before and after lung transplantation, highlighting how these experiences are deeply embedded within a network of family and social connections. This chapter emphasizes the
This chapter introduces systematic reviews and provides a summary of systematic review methods. Because of the challenges in palliative care trials, systematic reviews might be even more relevant in palliative care than in many other areas of health care. This chapter highlights the reasons why a researcher should use a systematic review, as well as the instances when systematic reviews are not an
