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The additional transplantation of ex vivo generated hematopoietic (post)-progenitor cells represents a possible approach to ameliorate high-dose chemotherapy induced cytopenia. We investigated the feasibility of the large-scale expansion and transplantation of autologous megakaryocytic cells in four patients with advanced solid tumors. Up to 1,460x10(6) ex vivo generated cells were administered wi
In winter, small birds should be fat to avoid starvation and lean and agile to escape predators. This means that they face a tradeoff between the costs and benefits of carrying fat reserves. Every day they must gain enough fat to survive the coming night. Food-hoarding species can afford to carry less fat than nonhoarders because they can store energy outside the body. Furthermore, hoarders should
Temperature is an important factor regulating microbial activity and shaping the soil microbial community. Little is known, however, on how temperature affects the most important groups of the soil microorganisms, the bacteria and the fungi, in situ. We have therefore measured the instantaneous total activity (respiration rate), bacterial activity (growth rate as thymidine incorporation rate) and
High-resolution records of plant macrofossils, magnetic susceptibility, and total carbon content, complemented by pollen data, were obtained from a postglacial lake sediment sequence at alpine Lake Stentjarn (987 m a.s.l.), in west-central Sweden. Holocene vegetational and environmental changes were reconstructed from the data, with particular emphasis on the deglacial establishment of terrestrial
Studiens syfte var att undersöka hur många föräldrar som efter förlossningen önskade kontinuitet mellan graviditet och nyföddhetsperiod genom ett hembesök av den barnmorska som man lärt känna under graviditeten, hur dessa kvinnor och män formulerade sina erfarenheter och behov, om de skilde sig från föräldrar som inte önskade hembesök och om resultatet kunde ge synpunkter på en individualiserad hä
This thesis focuses on the provision and management of water supply and sanitation in housing areas in the City of Dar es Salaam. The main objective of the study is to contribute to knowledge and understanding of provision and management of urban water supply and sanitation in Tanzania in the context of sustainable urbanisation. A sectoral and single problem issue study approach was avoided and in
Circulating insulin is dependent on a balance between insulin appearance through secretion and insulin clearance. However, to what extent changes in insulin clearance contribute to the increased insulin levels after glucagon administration is not known. This study therefore assessed and quantified any potential effect of glucagon on insulin kinetics in mice. Prehepatic insulin secretion in mice wa
The detailed nature of electronic states mediating ferromagnetic coupling in dilute magnetic semiconductors, specifically (Ga,Mn)As, has been an issue of long debate. Two confronting models have been discussed emphasizing host band versus impurity band carriers. Using angle resolved photoemission we show that the electronic structure of the (Ga,Mn)As system is significantly modified from that of G
Background and aims Chronic kidney disease leads to uremia and markedly accelerates atherosclerosis. Phenotypic modulation of smooth muscle cells (SMCs) in the arterial media plays a key role in accelerating atherogenesis. The aim of this study was to investigate whether uremia per se modulates the phenotype of aortic SMCs in vivo. Methods Moderate uremia was induced by 5/6 nephrectomy in apolipop
Background Microsatellite instability arises due to defect mismatch repair (MMR) and occurs in 10–20% of sporadic colorectal cancer. The purpose was to investigate correlations between defect MMR, prognosis and heredity for colorectal cancer in first-degree relatives. Material and methods Tumour tissues from 318 patients consecutively operated for colorectal cancer were analysed for immunohistoche
Foot problems complicating diabetes are a source of major patient suffering and societal costs. To prevent, or at least reduce, the adverse effects of foot problems in diabetes, the International Working Group on the Diabetic Foot (IWGDF; www.iwgdf.org) was founded in 1996, consisting of experts from almost all the disciplines involved in the care of patients with diabetes and foot problems. An im
The discovery of reliable biomarkers to predict efficacy and toxicity of anticancer drugs remains one of the key challenges in cancer research. Despite its relevance, no efficient study designs to identify promising candidate biomarkers have been established. This has led to the proliferation of a myriad of exploratory studies using dissimilar strategies, most of which fail to identify any promisi
Ineffective antimicrobial therapy of Pseudomonas aeruginosa bacteraemia increases mortality. Recent studies have proposed the use of antimicrobial combination therapy composed of a beta-lactam with either ciprofloxacin or tobramycin. To determine if combination therapy correlates to lower mortality and is superior compared to monotherapy, we investigated the effect of antimicrobial treatment regim
Background: B-cells are essential in immunity against malaria, but which sub-sets of B-cells specifically recognize Plasmodium falciparum and when they appear is still largely unknown. Results: Using the flow cytometry technique for detection of P. falciparum specific (Pf+) B-cells, this study for the first time measured the development of Pf+ B cell (CD19+) phenotypes in Ugandan babies from birth
En unik samling medeltida skatter från skånska kyrkor finns bevarade till våra dagar. Dessa liturgiska föremål som använts i gudstjänstens cermoniel, beskrivs här i ord och bild. Guldsmedernas och bronsgjutarnas praktfulla alster belyses utifrån sin funktion och sitt stilhistoriska sammanhang. Personliga ägodelar såsom smycken och pilgrimsmärken ger oss samtidigt en inblick i hur den kristna kultu
Ett nyupptäckt medeltida stenhus i Färlövs kyrkby, Östra Göinge, blev hösten 2011 föremål för en kortvarig, inledande undersökning. En välbevarad, aristokratiskt präglad anläggning har börjat framträda, i ett läge strax väster om Färlövs romanska stenkyrka med sina välkända tvillingtorn. En medeltida huvudgård i kyrkbyn är känd i dokumenten, och här finns ett ännu något oklart men intressant samba
