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OBJECTIVE - To evaluate proinsulin secretion in different types of NIDDM. RESEARCH DESIGN AND METHODS - Proinsulin and insulin were evaluated at diagnosis of diabetes and 3 years later (fasting and after stimulation with intravenous glucose and glucagon) in 10 NIDDM patients without islet cell antibodies (ICAs) at diagnosis (age 52 ± 4 years), 11 NIDDM patients with ICAs at diagnosis (age 50 ± 5 y

Nitric oxide (NO) exerts its vasodilator and antiaggregatory effects through activation of soluble guanylate cyclase and the consequent increase in the concentration of cGMP in target cells. We conducted this study in order to evaluate relationships between intraplatelet cGMP levels and risk factors for atherosclerosis in middle aged subjects. Intraplatelet cGMP was determined by radioimmunoassay

To clarify whether metabolic control and β‐cell function deteriorate with increasing duration of diabetes, we investigated in a cross‐sectional study Type 2 diabetic patients in an area‐based population. Type 2 diabetic patients (n = 231: 112 males, 119 females) were identified by age at onset > 35 years, fasting levels of C‐peptide > 0.04 nmol l−1, and absence of islet cell antibodies. Body weigh

We examined if plasma phosphorylated tau is associated with neurodegeneration in Alzheimer’s disease. We investigated 372 cognitively unimpaired participants, 554 mild cognitive impairment patients, and 141 Alzheimer’s disease dementia patients. Tau phosphorylated at threonine 181, regional cortical thickness (using magnetic resonance imaging) and hypometabolism (using fluorodeoxyglucose positron

Lactone flavors with fruity, milky, coconut, and other aromas are widely used in the food and fragrance industries. Lactones are produced by chemical synthesis or by biotransformation of plant-sourced hydroxy fatty acids. We established a novel method to produce flavor lactones from abundant non-hydroxylated fatty acids using yeast cell factories. Oleaginous yeast Yarrowia lipolytica was engineere

To respond to the question of whose interest proportionality serves, this article enquires into the function of this important principle. As the article argues, proportionality functions in much the same way as any generally applicable pragmatic principle: it facilitates comprehension of communicative behaviour on the part of utterers, in this case international lawmakers. Thus, the principle of p

The oleaginous yeast Yarrowia lipolytica is an emerging host for production of fatty acid-derived chemicals. To enable rapid iterative metabolic engineering of this yeast, there is a need for well-characterized genetic parts and convenient and reliable methods for their incorporation into yeast. Here, the EasyCloneYALI genetic toolbox, which allows streamlined strain construction with high genome

This article considers whose interests may be at stake when a company claims its human rights under the European Convention on Human Rights (echr). In order to do that, the article will first investigate whether it makes sense to conceive of companies as persons capable of having their own interests. It finds that it is possible to do so. The article proceeds to analyse the case law of the Europea

Background: Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. Methods: In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly

This chapter explores current and prospective reproductive technologies and some of their likely implications for reproductive and family ethics and policymaking. The technologies discussed include uterus transplants, mitochondrial transfer, ectogenesis, the development of in vitro gametes, and solo reproduction. The chapter considers the impact of these developments on the content of concepts suc

It has been argued that, when there is a probable imminent risk of loss of children's fertility, their parents should take active steps to preserve their reproductive potential if possible – or even that children have a right to such interventions being undertaken on them on their behalf, as an expression of their right to an open future. In this chapter, I explore these proposals and some of thei

n this paper, we will discuss the prospect of human reproduction achieved with gametes originating from only one person. According to statements by a minority of scientists working on the generation of gametes in vitro, it may become possible to create eggs from men’s non-reproductive cells and sperm from women’s. This would enable, at least in principle, the creation of an embryo from cells obtai

In the title of Reza Banakar’s first internationally published book The Doorkeepers of the Law: A Socio-Legal Study of Ethnic Discrimination in Sweden (1998) his interest in Franz Kafka is already obvious. Much later, Banakar (2010) presented his view of Kafka's conception of law in his article In Search of Heimat: A Note on Franz Kafka's Concept of Law, and more recently, Banakar (2015) developedIn the title of Reza Banakar’s first internationally published book The Doorkeepers of the Law: A Socio-Legal Study of Ethnic Discrimination in Sweden (1998) his interest in Franz Kafka is already obvious. Much later, Banakar (2010) presented his view of Kafka's conception of law in his article In Search of Heimat: A Note on Franz Kafka's Concept of Law, and more recently, Banakar (2015) developed

Previous research demonstrates that conflict framing in news articles can influence individuals’ attention, selection, and distribution of news. However, no study has examined whether the valence of social media comment fields can trigger similar effects for news engagement on Facebook. In this mixed-methods study, we combine eye tracking with surveys, and conduct an experiment in which participan

Recent advances in 3D bioprinting allow for generating intricate structures with dimensions relevant for human tissue, but suitable bioinks for producing translationally relevant tissue with complex geometries remain unidentified. Here, a tissue-specific hybrid bioink is described, composed of a natural polymer, alginate, reinforced with extracellular matrix derived from decellularized tissue (rEC

Brigadier General Hossein Dehghan, a commander of the Islamic Revolutionary Guard Corps, has announced his candidacy for the Iranian presidential elections in June 2021. Dehghan has a toxic military background. In the 1980s he was responsible for the vicious crackdown on opponents of the Islamic regime, and he played a central role in the bombing of the US Marine barracks in Beirut that killed hun