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BACKGROUND: Hereditary non-polyposis colorectal cancer (HNPCC) (Lynch cancer family syndrome I (LCFS1) and II (LCFS2)) is one of the most common hereditary cancer disorders. HNPCC results from dominantly inherited germline mutations in mismatch repair (MMR) genes, leading to genomic instability and cancer. No predictive physical signs of HNPCC are available to date. AIMS: Increased complexity in t

Popular Abstract in Swedish De flesta primärar hjärntumörer utgår ifrån astrocyter, oligodendrocyter och ependymala celler, som är hjärnvävnadens egna celler. Cirka hälften av dessa tumörer ingår i en grupp där tumörtypen heter gliom. Glioblastoma multiforme (GBM) är den mest elakartade tumören inom denna grupp och också den vanligast förekommande.Trots stora forskningssatsningar är behandlingsstrGlioblastoma multiforme (GBM) is the most malignant and also the most common form of brain tumour in humans. The overall aim of this thesis was to investigate morphological and diagnostics features in human GBM that may be of importance for prognosis and treatment. Immunohistochemically stained tissue sections have been microscopically analysed regarding immuno-reactive cells, cell proliferation,

Background: Loss of chromosome 11q defines a subset of high-stage aggressive neuroblastomas. Deletions are typically large and mapping efforts have thus far not lead to a well defined consensus region, which hampers the identification of positional candidate tumour suppressor genes. In a previous study, functional evidence for a neuroblastoma suppressor gene on chromosome 11 was obtained through m

A theoretical model has been developed for the drop behaviour in siphon riser tubes in paper drying cylinders. Analytical solutions to the equations are presented for the systems air-water at atmospheric pressure and saturated steam-water. Numerical simulations are performed for a large number of input data. Calculated drop trajectories indicate that the drops travel only a small part of the riser

A group of chest physicians, general practitioners, clinical pharmacologist and pharmacists appointed by the Institute of Pharmacotherapy, University of Oslo has evaluated the present knowledge about treatment of chronic obstructive lung disease. The group discusses today's medical treatment of this rather numerous group of patients. It is stated that, to a high degree, the treatment of these pati

Severely deficient activity of the von Willebrand Factor (VWF) cleaving metalloprotease,ADAMTS 13, is associated with thrombotic thrombocytopenic purpura (TTP). The mutation spectrum ofADAMTS 13 is rather heterogeneous, and numerous mutations spread across the gene have been described in association with congenital TTP. The 4143insA mutation is unusual with respect to its geographic concentration.

Popular Abstract in Swedish Syftet med studien är att bestämma de faktorer som påverkar eleverna då de löser matematiska problem i årskurserna 4-9 i grundskolan. Metoden, som använts, består i en analys av lösningarna till 25 problem, som getts i var och en av årskurserna. Några av problemen har varit desamma i alla årskurserna och ungefär 100 elever har deltagit i varje årskurs. Genom att undersöThe purpose of this study is to identify the factors influencing pupils when they individually solve problems in mathematics in grades 4-9 in the compulsory school (ages: 10-16 years). The method that has been used is an analyses of the solutions of 25 problems given to each grade. Some of the problems were the same in all grades and about 100 pupils participated in each grade. Through an examinat

The kinetics of oxidation of hydroxylamine by iron() have been studied spectrophotometrically. The effects of pH, reactant and product concentrations led to two experimental rate expressions. The results obtained are consistent with a mechanism dependent on the relative iron(III)-to-hydroxylamine concentrations; an excess of iron() gives a stoichiometry of 2 : 1 for the total reaction and N2O as t

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) wa

A MeV proton beam with a current in the range of fA-nA is usually measured using a secondary beam signal that is dependent on a sample or requires noise-free accurate charge integration in a Faraday cup. We propose a simple on-line beam current measurement setup that can be used to directly measure beam current during ion beam analysis. A fast beam blanker is used to modulate the beam position aft

Salmonella typhimurium is an intracellular bacterium that replicates in the spleen and mesenteric lymph nodes (MLN) of orally infected mice. However, little is known about the Ag presentation and cytokine production capacity of dendritic cells (DC), particularly CD8alpha(+), CD8alpha(-)CD4(-), and CD8alpha(-)CD4(+) DC, from these organs in response to SALMONELLA: Infection of purified splenic DC w

The reported rate of detection of Chlamydia pneumoniae DNA within atherosclerotic lesions by PCR varies between 0 and 100%. In this study, identical sets of coded experimental atheroma samples (n = 15) and spiked controls (n = 5) were analyzed by 16 test methods in nine centers by means of PCR. The positive controls were correctly identified to levels of 1, 0.1, and 0.01 inclusion bodies of C. pne

We studied the prevalence of musculoskeletal pain and its impact on performance in orchestra musicians and in a reference group of actors, who share the mental stress in a performance situation, but without having the physical work load from an instrument. Swedish musicians (n = 103) from symphony and chamber orchestras and actors (n = 106) participated in a cross-sectional questionnaire study. Mu

The steadily increasing prevalence of diabetes constitutes a major health problem. By the year 2025, the prevalence of diabetes is estimated to be as high as 5.4 %. This is to be compared with reports from Swedish coronary care units, which suggest that as many as 66 % of the patients admitted in fact have previously undiagnosed diabetes or pre-diabetes (impaired glucose tolerance) 1. Cardiovascul