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Detection and characterization of an ultra-dense sub-Neptunian planet orbiting the Sun-like star K2-292

We present the discovery and characterization of a new transiting planet from Campaign 17 of the Kepler extended mission K2. The planet K2-292 b is a warm sub-Neptune on a 17 day orbit around a bright (V = 9.9 mag) solar-like G3 V star with a mass and radius of M∗ = 1.00 ± 0.03 MȮ and R∗ = 1.09 ± 0.03 RȮ, respectively. We modeled simultaneously the K2 photometry and CARMENES spectroscopic data and

Infrared Drying Characteristics and Quality Variations of Lily Bulbs Under Blanching Pretreatment

Infrared drying characteristics and quality variations (color change, hardness, contents of polyphenol and flavonoid) of lily bulbs under blanching pretreatment are investigated. Influences of parameters such as pretreatment temperature and time and infrared drying temperature are discussed. Effective moisture diffusivity coefficient, activation energy, and energy consumption were calculated. Resu

Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease

Background: Alzheimer’s disease (AD) is a progressive multifaceted neurodegenerative disorder for which no disease-modifying treatment exists. Neuroinflammation is central to the pathology progression, with evidence suggesting that microglia-released galectin-3 (gal3) plays a pivotal role by amplifying neuroinflammation in AD. However, the possible involvement of gal3 in the disruption of neuronal

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequencing from a common set of 1220 cancer cases, we report hundreds of genes for which the presence within 100 kb of an SV breakpoint associates with altered e

Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes

Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency < 1%) predicted damaging coding variation by using sequence data from >170,000 individuals from multiple ancestries: 97,493 European, 30,025 South Asian, 16,507 African,

The oxidative balance and stopover departure decisions in a medium- and a long-distance migrant

Background: Birds have extremely elevated metabolic rates during migratory endurance flight and consequently can become physiologically exhausted. One feature of exhaustion is oxidative damage, which occurs when the antioxidant defense system is overwhelmed by the production of damaging reactive oxygen species (ROS). Migrating birds have been shown to decrease the amount of oxidative lipid damage

Electric heavy-duty trucks - Policy Outlook : Planned and implemented policies to support battery electric heavy-duty vehicles in Sweden, Austria, Germany, the Netherlands, UK and California (US)

The transport sector accounted for 37% of global CO2 emissions from end-use sectors in 2021. For the transport- and road freight sector to contribute to emissions reduction targets while still meeting the foreseen increase in transport demands, decarbonization will play a key role. This study focus on battery-electric heavy-duty trucks and the objective is to provide an overview of policy instrume

Declarative Specification of Intraprocedural Control-flow and Dataflow Analysis

Static program analysis plays a crucial role in ensuring the quality and security of software applications by detecting and fixing bugs, and potential security vulnerabilities in the code. The use of declarative paradigms in dataflow analysis as part of static program analysis has become increasingly popular in recent years. This is due to its enhanced expressivity and modularity, allowing for a h

Carbon taxes and agriculture: the benefit of a multilateral agreement

Reducing greenhouse gas emissions from agriculture is crucial to reach global and regional climate targets. However, the efficiency of unilateral climate policies aimed at taxing emissions might be hampered by carbon leakage. One way to eliminate leakage is to implement a global carbon tax. In this article, we study the effects of a carbon tax in agriculture on GHG emissions by simulating five polReducing greenhouse gas emissions from agriculture is crucial to reach global and regional climate targets. However, the efficiency of unilateral climate policies aimed at taxing emissions might be hampered by carbon leakage. One way to eliminate leakage is to implement a global carbon tax. In this article, we study the effects of a carbon tax in agriculture on GHG emissions by simulating five pol

The Transiting Multi-planet System HD15337 : Two Nearly Equal-mass Planets Straddling the Radius Gap

We report the discovery of a super-Earth and a sub-Neptune transiting the star HD 15337 (TOI-402, TIC 120896927), a bright (V = 9) K1 dwarf observed by the Transiting Exoplanet Survey Satellite (TESS) in Sectors 3 and 4. We combine the TESS photometry with archival High Accuracy Radial velocity Planet Searcher spectra to confirm the planetary nature of the transit signals and derive the masses of

Polyvalent incorporation of anionic β-cyclodextrin polymers into layer-by-layer coatings

As versatile compounds forming host-guest complexes with a wide variety of hydrophobic molecules, cyclodextrins are widespread candidates to confer functionalities to surfaces, particularly for drug delivery applications in the field of biomaterials, and for analytic or preparative purposes in separative sciences. We report here on Layer-by-Layer coatings used to decorate surfaces with β-cyclodext

Charge-Separated States Determined Photoinduced Electron Transfer Efficiency in a D-D-A System in an External Electric Field

Focusing on the photoinduced electron transfer properties of the D-D-A molecule ((TPA-TT)-BODIPY-C60) in an external electric field (Fext), the excited-state properties in which the double-donor molecule is excited to form three charge-separated states were simulated. The charge-Transfer processes of these three charge-separated states were investigated by considering the two donors as a whole ((T

F8/F9 variants in the population-based PedNet Registry cohort compared with locus-specific genetic databases of the European Association for Haemophilia and Allied Disorders and the Centers for Disease Control and Prevention Hemophilia A or Hemophilia B Mutation Project.

BACKGROUND: Hemophilia A and B are caused by variants in the factor (F) VIII or FIX gene. Selective reporting may influence the distribution of variants reported in genetic databases.OBJECTIVES: To compare the spectrum of F8 and F9 variants in an international population-based pediatric cohort (PedNet Registry) with the spectrum found in the European Association for Haemophilia and Allied Disord

Other protein blood groups

Antigens of the remaining 35 blood group systems are carried by glycoproteins. This chapter addresses only those antigens that elicit formation of clinically significant antibodies while briefly commenting on the other blood group systems. The most commonly encountered antibodies are directed against the M, N, S, and s antigens. The Lutheran blood group system contains multiple antigens; however,

Exploring the sustainability of the teaching profession : A thematic analysis of teachers’ perspectives

Teacher shortage and turnover is a growing problem in Sweden, yet little is known about the organisational factors associated with these problems. The current study explores teachers’ experiences of organisational processes and aims to identify relevant job demands and resources linked to professional sustainability for teachers. In this study, semi-structured focus group-interviews were conducted

RNA in cancer

RNA based processes are in the limelight due to the current technological advances from the fields of high throughput sequencing, structural probing and super-high resolution imaging. RNA biology is implicated in wide range of processes including embryonal development, maintenance of tissue homeostasis or tumor development and progression. We now gain insights at the unprecedented level on how RNA