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OBJECTIVE: The authors sought to clarify the components of the familial liability to alcohol use disorder (AUD) by examining parent-offspring transmission in a large Swedish population sample. METHODS: To this end, 1,244,516 offspring in intact families with a mean age at follow-up of 37.7 years (SD=6.8) were examined. Hazard ratios for offspring of parents with AUD were calculated using Cox model

The central complex (CX) is a highly conserved region of the insect brain, and its ubiquitous occurrence suggests that its neural circuits are of fundamental importance. While its overall layout has not changed since the evolution of insect flight, substantial variations exist in the internal organization of all CX components. By changing the details of a system of repeating columns and layers, th

Aim: Ultraviolet B (UVB) radiation can compromise the functionality of the skin barrier through various mechanisms. We hypothesize that UVB induce photochemical alterations in the components of the outermost layer of the skin, known as the stratum corneum (SC), and modulate its antioxidative defense mechanisms. Catalase is a well-known antioxidative enzyme found in the SC where it acts to scavenge

We give a complete proof of the classical Benjamin and Lighthill conjecture for arbitrary two-dimensional steady water waves with vorticity. We show that the flow force constant of an arbitrary smooth solution is bounded by the flow force constants for the corresponding conjugate laminar flows. We prove these inequalities without any assumptions on the geometry of the surface profile and put no re

Van Hove singularities (VHss) in the vicinity of the Fermi energy often play a dramatic role in the physics of strongly correlated electron materials. The divergence of the density of states generated by VHss can trigger the emergence of phases such as superconductivity, ferromagnetism, metamagnetism, and density wave orders. A detailed understanding of the electronic structure of these VHss is th

Projecting land-use allocation under various scenarios can be useful for reconciling conflicts between urbanization, food security, and ecological integrity throughout landscapes, but existing approaches often fail to capture the interactions in land systems that occur across scales and within and between hierarchical jurisdictions of societal organization. This article introduces a cross-scale fu

To describe the phenotype of a novel form of autosomal dominant episodic nystagmus and to identify the potential genetic aetiology. We identified several individuals in a large Swedish family affected by episodic nystagmus. In total, 39 family members from five generations were invited to participate in the study, of which 17 were included (12 affected and 5 unaffected). The phenotype of the nysta

We report micrometric imaging measurements of the ignition of micron-sized aluminum (Al) wires and the consequent combustion processes of single micron-sized Al droplets in hot steam and steam with oxygen. The specially designed flames were anchored on a modified burner where a small central H2/O2 diffusion flame in the center jet provided a hot flow (>2330 K) for Al ignition, and the diffusion fl

Finding reliable photocatalysts capable of driving reactions using only sunlight is more needed than ever. A variety of strategies to harvest sunlight and convert it into chemical energy have been successfully utilized such as synthesizing nanostructures, using metal nanoparticles, doping, and others. In this work, we discover a facile way to anchor CuS nanoplatelets on 2D MoS2 by the solvothermal

Upper-body adiposity is adversely associated with metabolic health whereas the opposite is observed for the lower-body. The neck is a unique upper-body fat depot in adult humans, housing thermogenic brown adipose tissue (BAT), which is increasingly recognised to influence whole-body metabolic health. Loss of BAT, concurrent with replacement by white adipose tissue (WAT), may contribute to metaboli

We have investigated the optical properties of heterostructured InGaN platelets aiming at red emission, intended for use as nano-scaled light-emitting diodes. The focus is on the presence of non-radiative emission in the form of dark line defects. We have performed the study using hyperspectral cathodoluminescence imaging. The platelets were grown on a template consisting of InGaN pyramids, flatte

Introduction: Acoustic noise from magnetic resonance imaging (MRI) can cause hearing loss and needs to be mitigated to ensure the safety of patients and personnel. Capturing MR personnel's insights is crucial for guiding the development and future applications of noise-reduction technology. This study aimed to explore how MR radiographers manage acoustic noise in clinical MR settings. Methods: Usi

In classical thermodynamics energy always flows from the hotter system to the colder one. However, if these systems are initially correlated, the energy flow can reverse, making the cold system colder and the hot system hotter. This intriguing phenomenon is called "anomalous energy flow"and shows the importance of initial correlations in determining physical properties of thermodynamic systems. He

The past evolution of precipitation and atmospheric convection in the Western Pacific Warm Pool (WPWP) is critical for global climate changes but is under debate because of its forcing mechanisms. Here, we present a high temporal resolution (∼156 years) grain-size record of core MD01–2385 over the last 140 kyr, in offshore northern New Guinea to reveal sediment dynamics as a proxy for precipitatio

Experience of out-of-home care (OHC) is associated with life-long vulnerability, and research indicates that parents with experiences of OHC are at higher risk of having their own children placed in out-of-home care. However, research on these parents is limited and lacks a resilience perspective. Here, we focused on parents with OHC experience as children but with custody of their own children (N

This paper formalizes the use of integral and differential cumulants for measurements of multiparticle event-by-event transverse momentum fluctuations, rapidity fluctuations, as well as net-charge fluctuations. This enables the introduction of multiparticle balance functions, defined based on differential correlation functions (factorial cumulants), that suppress two- and three-prong resonance dec

Poorly crystalline Al and Fe minerals have high sorption capacities for phosphate anions. However, there is still uncertainty about the molecular-level distribution of phosphorus (P) species between Al and Fe mineral phases, which can be relevant for bioavailability. The present study employed synchrotron X-ray microscopic techniques to distinguish between Al- and Fe-associated P phases in two Pod

Schreckstoff (fear substance) is an alarm signal released by injured fish that induces a fear response. Its chemical nature has long been debated. A new study finds that zebrafish Schreckstoff is composed of at least three components, two of which elicit the fear response only in combination.