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Genetic variation in the C-type lectin receptor CLEC4M in type 1 von Willebrand Disease patients

von Willebrand factor (VWF) levels in healthy individuals and in patients with type 1 von Willebrand disease (VWD) are influenced by genetic variation in several genes, e.g. VWF, ABO, STXBP5 and CLEC4M. This study aims to screen comprehensively for CLEC4M variants and investigate their association with type 1 VWD in the Swedish population. In order to screen for CLEC4M variants, the CLEC4M gene re

Uncertainty after heart transplantation. A new perspective on self-efficacy and self-management.

Background Self-management is the main concept constituting the foundation of follow-up care after heart transplantation. Self-efficacy is a foundation of self-management. Little is known about heart recipients’ experiences in relation to self-efficacy and self-management after heart transplantation. Aim The overall aim of this thesis was to explore uncertainty and self-efficacy as important aspecBackground Self-management is the main concept constituting the foundation of follow-up care after heart transplantation. Self-efficacy is a foundation of self-management. Little is known about heart recipients’ experiences in relation to self-efficacy and self-management after heart transplantation. Aim The overall aim of this thesis was to explore uncertainty and self-efficacy as important aspec

Structural health monitoring of concrete structures using diffuse waves

The work presented in this thesis has aimed to investigate and implement techniques for ultrasonic measurements in structural health monitoring applications for civil structures. The focus of the work has been to make these systems practical in real applications, where the large size of the structures, and the changing environments they are exposed to, pose problems for many methods which otherwis

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and

Atomic-Scale Choreography of Vapor-Liquid-Solid Nanowire Growth

ConspectusFunctional materials and devices require nanoscale control of morphology, crystal structure, and composition. Vapor-liquid-solid (VLS) crystal growth and its related growth modes enable the synthesis of 1D nanostructures, commonly called "nanowires", where the necessary nanoscale heterogeneity can be encoded axially. During the VLS process, a seed particle collects atoms and directs the

No title

Diskussion kring de så kallade centralplatserna från järnåldern utifrån nyaste litteratur. Fokus på Uppåkra i Skåne.

Communicating gender-equality progress, reduces social identity threats for women considering a research career

Abstract: Since the majority of top-level researchers are men, how does this vertical gender-segregation affect students’ perceptions of a research career? In the current study, an experimental manipulation either reminded students of academia’s current dominance of men, or of its improving gender-balance. The results showed that women primed with the dominance of men, anticipated much higher sociSince the majority of top-level researchers are men, how does this vertical gender-segregation affect students’ perceptions of a research career? In the current study, an experimental manipulation either reminded students of academia’s current dominance of men or of its improving gender-balance. The results showed that women primed with the dominance of men anticipated much higher social identity

Bild och natur : Tio konstvetenskapliga betraktelser

Anthology that investigates the complex relationship between nature and images. The book encompasses 10 chapters focusing on a wide range of empirical material, including photographic works, scientific images, news images, street art, public art, computer games, installation art, religious spaces and architecture.

350 näsor under 350 år

Lättsamt biografiskt översiktsverk med korta personbeskrivningar i ord och bild av dels de 190 personer som t o m 2017 införlivats i Akademiska Föreningens Nasotek, dels ytterligare 160 lundaanknutna historiska personer.

Lundagård och Frans G. Bengtsson

Beskrivning av bakgrunden till tidningen Lundagårds tillkomst samt översikt över Frans G Bengtssons kopplingar till och betydelse för tidningen under 1920-talet.

Efficiency, economy and effectiveness—but what about ethics? : Supreme audit institutions at a critical juncture

Ethics is increasingly recognized as one of several important dimensions of performance. Yet, performance audit, or value-for-money audit, as conducted by supreme audit institutions (SAIs), does not typically include this dimension. Instead, the focus is on the classical ‘three Es’ (efficiency, economy and effectiveness). The reluctance to address issues of ethical misconduct has taken the audit pEthics is increasingly recognized as one of several important dimensions of performance. Yet, performance audit, or value-for-money audit, as conducted by supreme audit institutions (SAIs), does not typically include this dimension. Instead, the focus is on the classical ‘three Es’ (efficiency, economy and effectiveness). The reluctance to address issues of ethical misconduct has taken the audit p

Generation of an integration-free induced pluripotent stem cell line (CSC-43J) from a patient with sporadic Parkinson's disease

An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and nor

Adiposity and genetic factors in relation to triglycerides and triglyceride-rich lipoproteins in the women's genome health study

BACKGROUND: Previous results from Scandinavian cohorts have shown that obesity accentuates the effects of common genetic susceptibility variants on increased triglycerides (TG). Whether such interactions are present in the US population and further selective for particular TG-rich lipoprotein subfractions is unknown. METHODS: We examined these questions using body mass index (BMI) and waist circum

European Society of Anaesthesiology and European Board of Anaesthesiology guidelines for procedural sedation and analgesia in adults

Procedural sedation and analgesia (PSA) has become a widespread practice given the increasing demand to relieve anxiety, discomfort and pain during invasive diagnostic and therapeutic procedures. The role of, and credentialing required by, anaesthesiologists and practitioners performing PSA has been debated for years in different guidelines. For this reason, the European Society of Anaesthesiology

Surface development of a brazing alloy during heat treatment-a comparison between UHV and APXPS

In an attempt to bridge the pressure gap, APXPS was used to follow the surface development of an aluminum brazing sheet during heating in an ambient oxygen-pressure mimicking the environment of an industrial brazing furnace. The studied aluminum alloy brazing sheet is a composite material consisting of two aluminum alloy standards whose surface is covered with a native aluminum oxide film. To emph

One evidence base; three stories : do opioids relieve chronic breathlessness?

The efficacy of low-dose systemic opioids for chronic breathlessness was questioned by the recent Cochrane review by Barnes et al We examined the reasons for this conflicting finding and re-evaluated the efficacy of systemic opioids. Compared with previous meta-analyses, Barnes et al reported a smaller effect and lower precision, but did not account for matched data of crossover trials (11/12 incl

Enhanced predictive capability of a 1-hour oral glucose tolerance test : A prospective population-based cohort study

OBJECTIVE To examine whether the 1-h blood glucose measurement would be a more suitable screening tool for assessing the risk of diabetes and its complications than the 2-h measurement. RESEARCH DESIGN AND METHODS We conducted a prospective population-based cohort study of 4,867men, randomly selected fromprespecified birth cohorts between 1921 and 1949,who underwent an oral glucose tolerance test