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BACKGROUND: Atypical antipsychotics have similar clinical efficacy in the treatment of schizophrenia; variability in their tolerability represents the discerning factor in treatment choices. Sertindole has a relatively good tolerability profile that favours long-term patient adherence and, therefore, is associated with lower rates of relapse and rehospitalization.AIM: A model was developed to comp
Mechanical phenotyping of single cells is an emerging tool for cell classification, enabling assessment of effective parameters relating to cells' interior molecular content and structure. Here, we present iso-acoustic focusing, an equilibrium method to analyze the effective acoustic impedance of single cells in continuous flow. While flowing through a microchannel, cells migrate sideways, influen
Modeling tank losses in a harmonic oscillator by means of an equivalent parallel resistance may lead to an optimistic estimate of phase noise, as recently experienced in a class-D CMOS oscillator. The discrepancy is significant if two conditions are fulfilled: The single-ended portion of the tank capacitance displays a non-negligible loss, and the loop gain of the oscillator is very large; in the
Protein self-assembly is extensively used in nature to build functional biomolecules and provides a general approach to design molecular complexes with many intriguing applications. Although computational design of protein-protein interfaces remains difficult, much progress has recently been made in de novo design of protein assemblies with cyclic, helical, cubic, internal and lattice symmetries.
Background:The association between smoking and breast cancer prognosis remains unclear. The purpose of this study was to investigate whether preoperative smoking was associated with prognosis in different treatment groups.Methods:This population-based cohort consisted of 1065 breast cancer patients without preoperative treatment included between 2002 and 2012 in Lund, Sweden. Smoking status was ex
Molecular dynamics is used to simulate nanometer-sized copper strips. The strips are highly constrained and chosen to mimic thin films between two stiff layers. Further, the strips hold centrally placed straight through crack shaped voids, and are subjected to tensile displacement controlled mode I loading. The tensile stresses and displacements are studied. It is found that if a copper strip is 2
This paper reports on a case study in which an at- size application is ported onto a commercially available processor array. Its purpose is threefold: (1) Determine the suitability of processor arrays for this kind of application. (2) Develop a runtime software infrastructure that supports streaming applications on processor arrays. (3) Gather data and insights into the resulting system performanc
In this paper, an experimental investigation on the influence of glue on the low frequency vibroacoustic performance (up to 200 Hz) of wooden T-junctions is presented along with a discussion of modelling issues related to the junctions. The mock-ups studied represent cut-outs of full size timber floor assemblies typically used in Sweden. Their dynamic performance was first studied experimentally b
The public sphere and public reason have recently become key ideas in global governance, with most scholars expressing related transparency and accountability concerns. This article contends that if transnational public sphere(s) and the use of reason in global policy-making aim to reinforce the common good and justice, they must go beyond the procedural concerns of transparency and accountability
Based on an ethnography at the Swedish Public Employment Service, this paper offers a typology of how employees managed to obey tasks they would rather not perform. It is argued that earlier studies of workplace obedience have tended to focus on a single mood in which the actor obeys: despair, cynicism, or seduction. Here, the movement between these moods is analysed. To pass from despair to cynic
Regioselective O-alkylation of an amide to form the corresponding imidate is a common synthetic problem, often resulting in varying amounts of N-alkylation. Screening existing methods for converting amides to imidates gave inconsistent or irreproducible results, sometimes affording N-alkylamide as the major product. A simple and reliable protocol for amide O-alkylation with complete regioselectivi
Numerous applications of membrane processes are feasible in pulp mills. The challenges inherent in these applications vary. High pH and high temperature call for ceramic membranes when treating spent pulping liquors, whereas low-cost membranes are needed when treating dilute process streams in mechanical pulp mills. Ultrafiltration has been used to recover lignosulphonate in sulphite pulp mills fo
Carroll's paper (Carroll) is most welcomed and shows that the weaker language is still to be explored from various points of views. Over twenty years after the publication of Schlyter's paper, “The weaker language in bilingual Swedish-French children”, not only is the topic of the weaker language of simultaneous bilinguals still a clearly under-researched area, but it is also, as Carroll shows, a
Photoisomerization of 1,1′-diethyl-2,2′-carbocyanine iodide (pinacyanol) in alcohols was investigated by means of femtosecond time-resolved absorption spectroscopy. Only one out of two possible types of photoisomer was found. Viscosity-dependent kinetics indicate that the excited state dynamics consist of two parts, associated with a barrier-crossing observed in the blue side of stimulated emissio
The electrical properties of ZrO2 and HfO2 gate dielectrics on n-InAs were evaluated. Particularly, an in situ surface treatment method including cyclic nitrogen plasma and trimethylaluminum pulses was used to improve the quality of the high-κ oxides. The quality of the InAs-oxide interface was evaluated with a full equivalent circuit model developed for narrow band gap metal-oxide-semiconductor (
The aim of the document is to identify and discuss a number of growth paths that might be explored to promote innovationdriven development in Sub-Saharan Africa. The document adopts a broad perspective of innovation, examining framework conditions, fundamental prerequisites, drivers and focal areas for innovation. The document addresses a spectrum of issues andtopics ranging from regional and glob
We demonstrate improved performance due to enhanced electrostatic control achieved by diameter scaling and gate placement in vertical InAs-GaSb tunneling field-effect transistors integrated on Si substrates. The best subthreshold swing, 68 mV/decade at VDS=0.3 V, was achieved for a device with 20-nm InAs diamter. The on-current for the same device was 35 µA/µm at VGS=0.5 V and VDS=0.5 V. The fabri
The present study focuses on a manager’s understanding of leadership and how this guides – or does not guide practice. The paper reports an empirical in-depth study of a middle manager in an international manufacturing company. We link our discussion to both – the mainstream leadership studies, which assume that managers have a solid type of leadership behavior, and authors with a meaning-oriented
This article takes a sceptical view of the functionalist understanding of the nature and significance of ‘knowledge’ in so-called knowledge- intensive companies. The article emphasizes the slipperiness of the concept of knowledge, the ambiguity of knowledge, its role in what is constructed as knowledge work and the evaluation of work outcomes. Given this ambiguity, the management of rhetoric, imag
