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Neuroblastoma is a neural crest-derived childhood tumor of the peripheral nervous system in which MycN amplification is a hallmark of poor prognosis. Here we show that MycN is expressed together with phosphorylation-stabilizing factor CIP2A in regions of the neural plate destined to form the CNS, but MycN is excluded from the neighboring neural crest stem cell domain. Interestingly, ectopic expres

The ATLAS luminosity monitor, LUCID (LUminosity Cherenkov Integrating Detector), had to be upgraded for the second run of the LHC accelerator that started in spring 2015. The increased energy of the proton beams and the higher luminosity required a redesign of LUCID to cope with the more demanding conditions. The novelty of the LUCID-2 detector is that it uses the thin quartz windows of photomulti

Building the European Spallation Source (ESS), the most powerful neutron source in the world, requires significant technological advances at most fronts of instrument component design. Detectors are not an exception. The existing implementations at current neutron scattering facilities are at their performance limits and sometimes barely cover the scientific needs. At full operation the ESS will y

Rather than maximizing intake of available macronutrients, insects increase intake of some nutrients and restrict intake of others. This selective consumption influences, and potentially optimizes, developmental time, reproduction and lifespan of the organism. Studies so far have focused on discriminating between protein and carbohydrate uptake and the consequences on fitness components at differe

Inbreeding depression is often intensified under environmental stress (i.e., inbreeding–stress interaction). Although the fitnessconsequences of this phenomenon are well-described, underlying mechanisms such as an increased expression of deleterious allelesunder stress, or a lower capacity for adaptive responses to stress with inbreeding, have rarely been investigated. We investigated afitness compon

Using a novel methodological approach to measure emotions in Facebook comments, this Work in Progress (WIP) paper explores the relationship between negative feelings and ideological cross-posting behavior. Using the VoxPopuli data harvester, we collect over 770,000 public Facebook comments1 from the three major political campaign pages active during the Brexit referendum. After sorting users into

A tailor shop located in Singapore’s Chinatown is explored as a case of creative linguistic marketing practice, examining how such practice can be understood in relation to the interaction of local and global forces on the linguistic landscape. The shop uses a range of Scandinavian semiotic resources (language and artefacts) which for us, coming upon the shop, seemed unexpected or, using Sweetland

We investigate the ability of Massive multiple-input multiple-output (MIMO) systems to spatially separate up to eighteen users located close to one another in line-of-sight (LOS) propagation conditions, in both indoor and outdoor environments. For that, we use fully-synchronous measured channels at 2.6 GHz of single-antenna users moving within a small area and concurrently communicating with a bas

Aims Preliminary studies suggest that direct stenting (DS) during percutaneous coronary intervention (PCI) may reduce microvascular obstruction and improve clinical outcome. Thrombus aspiration may facilitate DS. We assessed the impact of DS on clinical outcome and myocardial reperfusion and its interaction with thrombus aspiration among ST-segment elevation myocardial infarction (STEMI) patients

The rich vacuum structure of multi-Higgs extensions of the Standard Model (SM) may have interesting cosmological implications for the electroweak phase transition (EWPT). As an important example of such class of models, we consider a particularly simple low-energy SM-like limit of a recently proposed Grand-Unified Trinification model with the scalar sector composed of two Higgs doublets and a comp

Motility-induced phase separation leads to cohesive active matter in the absence of cohesive forces. We present, extend and illustrate a recent generalized thermodynamic formalism which accounts for its binodal curve. Using this formalism, we identify both a generalized surface tension, that controls finite-size corrections to coexisting densities, and generalized forces, that can be used to const

Objective: The aim was to compare the vitamin D levels in patients with Graves disease (GD) with the general population and to correlate the vitamin D levels with laboratory and clinical parameters in GD. Moreover, we examined the genetic variation in genes involved in the vitamin D metabolism and their association with GD.Methods: The levels of vitamin D were compared in 292 patients with newly d

Background: The Ca2+ binding apoptosis-linked gene-2 (ALG-2) protein acts as a proapoptotic factor in a variety of cell lines and is required either downstream or independently of caspases for apoptosis to occur. ALG-2 belongs to the penta-EF-hand (PEF) protein family and has two high-affinity and one low-affinity Ca2+ binding sites. Like other PEF proteins, its N terminus contains a Gly/Pro-rich

The penta-EF hand (PEF) family of calcium binding proteins includes grancalcin, peflin, sorcin, calpain large and small subunits as well as ALG-2. Systematic testing of the heterodimerization abilities of the PEF proteins using the yeast two-hybrid and glutathione S-transferase pull-down assays revealed the new finding that grancalcin interacts strongly with sorcin. In addition, sorcin and grancal

Hur vet vi vad som är rätt och fel i en situation? Och hur avgör vi hur vi ska handla? Lagar är tydligt nedskrivna och det finns föreskrivna sanktioner om man bryter mot lagen. Men så tydligt är inte vårt samhälle. När vi är laglydiga utan att känna till lagen följer vi egentligen normer. Vårt handlande styrs sällan enbart av lagar och regler utan av dessa, oskrivna och osynliga, normer.Normer och

In type 2 diabetes (T2D), hepatic insulin resistance is strongly associated with nonalcoholic fatty liver disease (NAFLD). In this study, we hypothesized that the DNA methylome of livers from patients with T2D compared with livers of individuals with normal plasma glucose levels can unveil some mechanism of hepatic insulin resistance that could link to NAFLD. Using DNA methylome and transcriptome

Several studies have proposed that small- and medium-sized enterprises (SMEs) lack resources and experiential knowledge to internationalise to distant markets. The authors argue that SMEs can handle the lack of these tangible and intangible internal resources through external collaborations; they can achieve success in international markets by collaborating with business partners. The role of inte

BACKGROUND: The addition of high-dose cytarabine to the treatment of mantle cell lymphoma (MCL) has significantly prolonged survival of patients, but relapses are common and are normally associated with increased resistance. To elucidate the mechanisms responsible for cytarabine resistance, and to create a tool for drug discovery investigations, we established a unique and molecularly reproducible

Development of antibody drugs against novel targets and pathways offers great opportunities to improve current cancer treatment. We here describe a phenotypic discovery platform enabling efficient identification of therapeutic antibody-target combinations. The platform utilizes primary patient cells throughout the discovery process and includes methods for differential phage display cell panning,

In recent years, subsets of chronic lymphocytic leukemia (CLL) patients carrying quasi-identical or stereotyped B cell receptors (BcRs) have been identified that share clinicobiological features and disease outcome. While these stereotyped subsets show distinct gene expression and genomic profiles, the DNA methylation landscape remains largely unexplored. By applying high-resolution 450K methylati