Altered secretion of insulin as well as glucagon has been implicated in the pathogenesis of Type 2 diabetes (T2D), but the mechanisms controlling glucagon secretion from alpha-cells largely remain unresolved. Therefore, we studied the regulation of glucagon secretion from alpha TC1-6 (alpha TC1 clone 6) cells and compared it with insulin release from INS-1 832/13 cells. We found that INS-1 832/13

Between the nation and the surrounding world - Debate in Sweden regarding the organisation and financing of research and its international and national aspects during the first half of the twentieth century My thesis regards the attitude of the Swedish research society to research as a national and an international phenomenon during the period 1900-1950. My work relates to the question in which w

Thin metallic nanowires are highly promising candidates for plasmonic waveguides in photonic and electronic devices. We have observed that light from the end of a silver nanowire, following excitation of plasmons at the other end of the wire, is emitted in a cone of angles peaking at nominally 45-60 degrees from the nanowire axis, with virtually no light emitted along the direction of the nanowire

Protein kinase C (PKC) δ is a regulator of apoptosis with both pro- and anti-apoptotic effects. The mechanistic basis for the discrepant effects is not completely understood. Here we show that Smac interacts with PKCδ. The interaction depends on the N-terminus of Smac and is disrupted upon treatment with paclitaxel. This is associated with release of Smac into the cytosol. Activation of PKCδ rescu

In the present work, near-limiting hydrogen flames were investigated both experimentally and numerically. Very rich hydrogen + air flames were studied in a constant volume bomb equipped with a pressure sensor and a Schlieren system for optical registration of the flame front movement. The mixtures contained 70% and 75% of hydrogen, the rest being air. The measurements were conducted at pressures f

Robust and reliable formulas for predicting bed load and suspended load were developed for application in the nearshore zone where waves and currents may transport sediment separately or in combination. Also, a routine was included to determine the sediment transport in the swash zone, both in the longshore and cross-shore directions. An important objective of the development was to arrive at gene

AimSpecies are responding to climate change by changing their distributions, creating debate about the effectiveness of existing networks of protected areas. As a contribution to this debate, we assess whether regional winter abundances and distribution of the Smew Mergellus albellus, a migratory waterbird species listed on Annex I (EU Birds Directive) that overwinters exclusively in European wetl

The article offers a new approach for the exploration of media and television studies by extracting the television-philosophy implicit in Samuel Beckett’s television play …but the clouds…. The reading focuses on the immanent logic of the play seen as a televisual and an intermedial whole, instead of constructing it as an intertextual tapestry of references. The article argues against a popular int

Statistical analysis of long-term morphological data on coastal sedimentary features provides important information on the processes governing these features and their evolution in space and time. In this paper, seasonal, yearly and decadal (i.e. long-term) behavior of coastal morphological features is derived from field data by using both simple and advanced statistical techniques. The sedimentar

In the last two decades, the Swedish welfare state has been radically transformed in a neo-liberal direction, including extensive decentralisation and marketisation of the education sector with significant consequences for the work and professional identities of its teachers. Teacher education has also been directly included in this transformation. The present article addresses the changes that ha

BackgroundDimethyl sulfoxide (DMSO) is essential for the preservation of liquid nitrogen-frozen stem cells, but is associated with toxicity in the transplant recipient. Study Design and MethodsIn this prospective noninterventional study, we describe the use of DMSO in 64 European Blood and Marrow Transplant Group centers undertaking autologous transplantation on patients with myeloma and lymphoma

Focusing clinical investigations on outcomes that are meaningful from an end-user perspective is central in clinical research, particularly in chronic disorders such as Parkinson's disease (PD). However, little is known about how end-users such as people with PD (PwPD) and health care professionals (HCPs) view and prioritize therapeutic outcomes. To compare the perspectives of PwPD and HCPs regard

The crystal structures of the binary cadmium-rich complex metal alloys NiCd6+delta (-0.32

The first measurement of two-pion Bose-Einstein correlations in central Pb-Pb collisions at root(NN)-N-S = 2.76 TeV at the Large Hadron Collider is presented. We observe a growing trend with energy now not only for the longitudinal and the outward but also for the sideward pion source radius. The pion homogeneity volume and the decoupling time are significantly larger than those measured at RHIC.

Atherosclerosis, thickening of the major arteries, is a chronic disease leading to cardiovascular disease (CVD) such as myocardial infarction (MI) and stroke, both affecting millions worldwide. T-cells and antibodies have been implicated in atherosclerosis. This thesis contains studies on CD4+ helper subsets and studies on antibodies against methylglyoxal-modified apolipoprotein B100 (MGO-ApoB100)

A landscape genetics approach was applied to common goby (Pomatoschistus microps) sampled from three estuaries (six sites) of the Portuguese coast. Individuals of each site were genotyped for eight microsatellite loci and levels of genetic diversity and differentiation were correlated to present-day estuarine characteristics and historical events. A general ecological state for each sampling site

The Cerro de Pasco epithermal Cordilleran base metal deposit in central Peru consists of two mineralization stages which are spatially and genetically related to a mid-Miocene diatreme-dome complex. In order to constrain the duration of the magmatic-hydrothermal system at Cerro de Pasco, U-Ph age determinations and Hf isotope determinations have been conducted on single zircon grains. Biotite from

A cohort of 1,220 farmers, 1,130 nonfarming rural men, and 1,087 urban referents from Sweden were monitored for 12 years. Farmers had lower mortality than urban referents for all causes of death (hazard ratio [HR] = 0.51; 95% confidence interval [CI], 0.37-0.71), cancer (HR = 0.44; 95% CI, 0.24-0.78) and cardiovascular diseases (HR = 0.60; 95% CI, 0.36-0.99). Nonfarming rural men had lower mortali