A Trick of the Tail: The Effect of Amyloid Formation on the pKa Values of α-synuclein
The formation of α-synuclein amyloid fibrils and accumulation in inclusion bodies termed Lewy bodies are considered the hallmark of Parkinson’s disease. It has been found that the formation of fibrils is highly pH dependent, which is thought to be linked to the highly negatively charged C-terminal tail of α-synuclein. The aim of this project was to study if the pKa values of the C-terminal tail in