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Background: Carotid atherosclerotic plaques with intraplaque hemorrhage (IPH) are associated with elevated stroke risk. IPH is predominantly imaged based on paramagnetic properties of the upstream hemoglobin degradation product methemoglobin. This is an explorative observational study to test the feasibility of a spoiled gradient echo based T2* weighted MRI sequence (3D MEDIC) for carotid plaque i

Background: Research and practice are often considered as two different worlds with different values, which causes a gap between them. Involving professionals such as practitioners, managers, decision-makers, and policy-makers in research on ageing and health might address the gap between research and practice, strengthen the healthcare system, and increase older people’s possibilities for healthy

Background: We investigated the alarming trend of curable head and neck cancer (HNC) patients forgoing conventional treatment to pursue alternative medicine (AM). Methods: A prospectively maintained database identified HNC patients with ≥12 weeks from diagnosis to treatment initiation between 2012 and 2017. Reasons for delay were categorized and clinical stages and outcomes of AM patients were ass

Background: The role of non-group A streptococci and Fusobacterium necrophorum in pharyngotonsillitis has been disputed and few prospective studies have evaluated the effect of antibiotic treatment. This study uses registry data to investigate the relation between antibiotic prescription for pharyngotonsillitis in primary healthcare and return visits for pharyngotonsillitis, complications, and ton

Microscopic diffusion anisotropy imaging using diffusion-weighted MRI and multidimensional diffusion encoding is a promising method for quantifying clinically and scientifically relevant microstructural properties of neural tissue. Several methods for estimating microscopic fractional anisotropy (µFA), a normalized measure of microscopic diffusion anisotropy, have been introduced but the differenc

Purpose: The majority of unconscious patients after cardiac arrest (CA) do not fulfill guideline criteria for a likely poor outcome, their prognosis is considered “indeterminate”. We compared brain injury markers in blood for prediction of good outcome and for identifying false positive predictions of poor outcome as recommended by guidelines. Methods: Retrospective analysis of prospectively colle

This ethnographic research on ‘Workaway’ investigates new forms of mobility experiences, in between travel and migration, which are used by a plethora of types of people (both hosts and guests) with different motivations (learning new skills and experiences), needs, ambitions, dreams, as well as/or life-time crisis, and different types of problems (e.g. lack of finances, no opportunity or prospect

Background: Despite scaling up of HIV programmes in sub-Saharan Africa, many people living with HIV (PLHIV) are unaware of their HIV status. New testing modalities, such as community-based testing, can improve test uptake, but it is uncertain whether type of testing modality affects the subsequent cascade of HIV care. Objective: To compare linkage to care and antiretroviral treatment (ART) outcome

The notion of Cloud RAN is taking a prominent role in narrative for the next generation wireless infrastructure. It is also seen as a mean to industrial communication systems. In order to provide reliable wireless connectivity for industrial deployments, by conventional means, the cloud infrastructure needs to be reliable and incur little latency, which however, is contradictory to the stochastic

1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) is widely used as a crosslinker for fluorescence labeling of protein in the fields of biochemistry and food analysis. Many natural polysaccharides often contain some proteins or peptides that are very low in content but play a vital role in their biological function as well as technical applications. Determination of these low-content proteinace

Eulerian stochastic fields (ESF) based transported PDF method has evolved as one of the general purpose methods for the numerical simulation of complex chemically reactive turbulent flows in which the effect of turbulence on the chemical reaction rates can be computed directly without the need of modeling. It is found that ESF method may suffer from violation of the element mass conservation law d

Apolipoprotein E (APOE), one of the primary lipoproteins in the brain has three isoforms in humans - APOE2, APOE3, and APOE4. APOE4 is the most well-established risk factor increasing the pre-disposition for Alzheimer's disease. The presence of the APOE4 allele alone is shown to cause synaptic defects in neurons and recent studies have identified multiple pathways directly influenced by APOE4. How

This paper proposes Yggdrasil, a protocol for privacy-aware dual data deduplication in multi-client settings. Yggdrasil is designed to reduce cloud storage space while safeguarding the privacy of clients’ data. This is achieved by exploiting a ‘dual’ setting, where both the cloud and the clients store a fraction of the data. Yggdrasil combines two innovative techniques to achieve this goal. First,

BACKGROUND: α-synuclein (α-syn) aggregation contributes to the progression of multiple neurodegenerative diseases. We recently found that the isoform b of the co-chaperone DNAJB6 is a strong suppressor of a-syn aggregation in vivo and in vitro. However, nothing is known about the role of the endogenous isoform b of DNAJB6 (DNAJB6b) in health and disease, due to lack of specific antibodies.OBJECTIV

The research presented in this thesis is primarily focused on experimental investigations of laser-driven ion acceleration from solid targets via the target normal sheath acceleration mechanism. In particular, ways of optimizing the absorption of the laser pulse energy by free plasma electrons in the target, or modifying the shape of the accelerating electron sheath were addressed. The aim of this

Past research on the social determinants of colorectal cancer (CRC) has shown that lower socioeconomic status (SES) is associated with a higher risk of CRC. Similar to SES at the individual level, the neighbourhood social environment may partly affect the development of CRC. Although one important aspect of the neighbourhood social environment is social capital, no large-scale follow-up study has

Zinc (Zn) is an important trace element that is essential for optimal plant growth. Zinc-solubilising bacteria can release Zn from its insoluble compounds. We isolated and identified Zn-solubilising bacteria (ZnSB) from the rhizosphere, and semi-quantitively and quantitatively evaluated their ability to dissolve various Zn minerals (ZnO, ZnCO3 and Zn3(PO4)2). Out of 24 rhizosphere soil samples, 15