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Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(IV) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between logkRS− and the thiol dissociation constants pKRSH is disclosed: logkRS− = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS− de

This study explores how cognitive heterogeneity at the team level-i.e., the degree to which team members adhere to conflicting cognitive frames-impacts entrepreneurial learning behavior. We analyze learning processes in a new-venture team over three time-periods, leveraging rich data from 20 interviews, 990 emails, and 62 internal documents. We find that during time-periods when the team encompass

Sauna sessions and winter swimming are traditional and popular recreational activities in certain countries. Their positive effects on health and relaxation, both as separate and combined activities, are commonly reported. However, systematic studies of these effects are relatively scarce, especially regarding the nonlinear analysis of the physiological measurements of the heart activity. We perfo

Modern wind turbines are designed to withstand approximately for a lifetime of 20 years [1]. However, a very long design life of 100 years or more can be expected for high-quality concrete foundations. Thus there is a big difference in lifetime between wind turbines and foundations. There is a significant economic benefit of replacing the out-of-date wind turbine with a new turbine of better power

The STAFF III database was acquired with the aim of better understanding the ECG signatures observed during acute ischemia, with special focus on high-frequency QRS components. The database contains recordings from 104 patients undergoing elective balloon percutaneous coronary intervention. The database has not only been analyzed in numerous clinical studies, but also turned out to be an excellent

A phenomenological model for simulating photoplethys-mogram (PPG) during paroxysmal atrial fibrillation (AF) is proposed. A PPG pulse is modeled by combining a lognormal and two Gaussian waveforms. Continuous PPG signals are produced by placing and connecting individual pulses according to the RR interval pattern extracted from annotated ECG signals. This paper presents a practical application of

In order to understand the nature of the relationship between cerebral blood flow (CBF) and primary headaches, we have conducted a literature review with particular emphasis on the role of perivascular neurotransmitters. Primary headaches are in general considered complex polygenic disorders (genetic and environmental influence) with pathophysiological neurovascular alterations. Identified candida

BACKGROUND AND OBJECTIVE: The study aimed to evaluate the predictive validity of the Brody self-report frailty index among older people. Design, setting and measurements: A longitudinal cohort study (2-years) conducted in Sweden, which included 1141 respondents, aged 65-103 years. Data were collected during 2011-2013 through a postal questionnaire with questions about demographic data, living cond

Passively viewing nature may promote psychological restoration relevant for office work. The objective of this paper is to explore how natural elements in the indoor work environment are experienced. An on-site assessment with between-subjects design (n = 56) and a photo-based assessment with a crossover design (n = 46) compared three interiors of a windowed office setting with either plants, inan

Purpose Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations are frequently observed in primary breast cancer. We evaluated their prognostic relevance by performing a pooled analysis of individual patient data. Patients and Methods Associations between PIK3CA status and clinicopathologic characteristics were tested by applying Cox regression models adjusted fo

Objectives: The aims of this study were to investigate the validity evidence for a novel procedure specific assessment tool of competence in endovascular aortic repair (EVAR) and to establish a pass/fail level for the assessment. Methods: Computed tomography angiography data of a 55 mm in diameter infrarenal aortic aneurysm was implemented into an endovascular simulator. Twenty-three physicians wi

Objectives: Antithymocyte globulin (ATG)-based immunosuppression remains a cornerstone in aplastic anaemia (AA) treatment. However, most ATG studies are not population-based and knowledge about real-world results concerning response and outcome could offer important information for treating physicians. Methods: We have recently performed a nationwide retrospective cohort study on all AA patients d

This thesis investigates the interaction between teaching and learning of English in young learners in Sweden and in Vietnam. It thus brings together two perspectives – teaching and learning – that are seldom compared between cultural contexts. The main focus of the study is to examine procedural and declarative knowledge of English grammar. A number of Grade 5 English lessons in primary school cl

Dysphonia is a program about impaired voice quality or hoarseness (i.e. dysphonia) mainly due to organic diseases of the larynx. The program aims to facilitate student oriented learning regarding the management of dysphonic patients. The targeted use is for training of undergraduate medical and speech pathology students, postgraduate residents under continuous medical education in the Ear,Nose, an

First results on the longitudinal asymmetry and its effect on the pseudorapidity distributions in Pb–Pb collisions at sNN = 2.76 TeV at the Large Hadron Collider are obtained with the ALICE detector. The longitudinal asymmetry arises because of an unequal number of participating nucleons from the two colliding nuclei, and is estimated for each event by measuring the energy in the forward neutron-Z

A measurement of the production of three isolated photons in proton–proton collisions at a centre-of-mass energy s=8 TeV is reported. The results are based on an integrated luminosity of 20.2 fb−1 collected with the ATLAS detector at the LHC. The differential cross sections are measured as functions of the transverse energy of each photon, the difference in azimuthal angle and in pseudorapidity be