Epithelial cells play an important role in maintaining the intestinal mucosa barrier, a barrier that is impaired in several inflammatory conditions. The mechanisms behind this impairment are not known, but it can be presumed that structural alterations of the epithelial cells are involved. In support of this notion, we here show the inflammatory mediator leukotriene D4 (LTD4) triggered first a rap

Mechanisms of resilience against tau pathology in individuals across the Alzheimer’s disease spectrum are insufficiently understood. Longitudinal data are necessary to reveal which factors relate to preserved cognition (i.e. cognitive resilience) and brain structure (i.e. brain resilience) despite abundant tau pathology, and to clarify whether these associations are cross-sectional or longitudinal

In international law, according to the Paris Convention for the Protection of Industrial Property, a coat of arms of a state and other state emblems are protected against use in trademarks. Included in the protection is also ”any imitation from a heraldic point of view” of the protected emblem. This phrase has been further defined in EU law. The Court of Justice of the European Union held in the ”

Detta kapitel har som utgångspunkt den historiska relationen mellan Alfred Nobel och Karlskoga, då kommunen nu mer än 100 år efter Alfred Nobels död försöker bygga upp platsvarumärket ”Alfred Nobels Karlskoga” i syfte att generera regional tillväxt och utveckling. Att använda sig av en känd person från bygden i syfte att marknadsföra en plats är inte ovanligt. Liknande exempel kan hämtas från exem

Building on the experiences from organising participatory urban art in the stigmatised suburbs of various Swedish cities, the article discusses the ways in which such processes democratise space and develop democratic praxis. It then points at the implications of such lessons for organising workplace democracy.

Background: With the increasing digitalization in health care, an effective instrument is necessary to assess health care consumers' digital competencies-their "eHealth literacy." The 7-scale eHealth Literacy Questionnaire (eHLQ), based on the theoretically robust eHealth Literacy Framework, has shown strong psychometric properties in Denmark and Australia.Objective: The aim of this study was to t

Background: Because overweight and obesity are still increasing and prevention of childhood obesity is more likely to be effective when initiated in preschool children, the Child Health Service in the south of Sweden developed a structured child-centred health dialogue model targeting all 4-year-old children and their families. The aim of this study was to describe parents' recalled experiences of

It is often a challenge for a child to communicate their pain, and their possibilities to do so should be strengthened in healthcare settings. Digital self-assessment provides a potential solution for person-centered care in pain management and promotes child participation when a child is ill. A child's perception of pain assessment differs when it is assessed using digital or analog formats. As w

Humans have an irresistible inclination to coordinate actions with others, leading to species-unique forms of cooperation. According to the highly influential Shared intentionality theory (SITh), human cooperation is made possible by shared intentionality (SI), typically defined as a suite of socio-cognitive and motivational traits for sharing psychological states with others, thereby enabling ind

Protein-DNA interactions are involved in many biological processes essential for gene expression and regulation. To understand the molecular mechanisms of protein-DNA recognition, it is crucial to analyze and identify DNA-binding residues of protein-DNA complexes. Here, we proposed a novel descriptor shape string and another two related features shape string PSSM and shape string pair composition

This text deals with the analysis of the removal of the monument to Soviet Marshal Ivan Konev from the Prague 6 district, an important part of the capital of the Czech Republic. The given monument was built during the Soviet occupation of Czechoslovakia in 1980 and removed in 2020. The primary reason for the removal was the dissatisfaction of the political representation of Prague 6 and the leader

Background: Tuberculosis (TB) and diabetes mellitus (DM) have negative synergistic impact on each other. Global guidelines recommend collaborative efforts to address this synergy, but implementation has been slow. Part of the reason is lack of adequate evidence on the operational feasibility of existing tools and mechanisms of collaboration. The objective of this study was to assess the yield of D

To end the global tuberculosis (TB) epidemic and eliminate TB, countries around the world committed to significantly expanding the scope of their efforts, including rapid uptake of new tools, interventions, and strategies, and envisioned a world free of TB. Between 2010 and 2020, Ethiopia experienced a 5% average annual decline in TB incidence. However, at that current rate, ending the TB epidemic

OBJECTIVES: Our objective was to evaluate the impact of a service delivery model led by membership-based associations called Iddirs formed by women on tuberculosis preventive treatment (TPT) initiation and completion rates among children.DESIGN: Comparative, before-and-after study design.SETTING: Three intervention and two control districts in Ethiopia.PARTICIPANTS: Children who had a history of c

BACKGROUND: The Xpert MTB/RIF Ultra (Xpert-Ultra) assay provides timely results with good sensitivity and acceptable specificity with stool specimens in children for bacteriological confirmation of tuberculosis (TB). This study aims to optimize the Simple One-Step (SOS) stool processing method for testing stool specimens using the Xpert-Ultra in children and adults in selected health facilities in