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Metabolic engineering for pentose utilization in Saccharomyces cerevisiae

The introduction of pentose utilization pathways in baker's yeast Saccharomyces cerevisiae is summarized together with metabolic engineering strategies to improve ethanolic pentose fermentation. Bacterial and fungal xylose and arabinose pathways have been expressed in S. cerevisiae but do not generally convey significant ethanolic fermentation traits to this yeast. A large number of rational metab

Urinary excretion of melanocyte metabolites during treatment with chloroquine phosphate

The antimalarial drug chloroquine is also used in the prevention of photodermatoses and in patients with inflammatory connective diseases. The drug binds strongly to melanin. Melanocytic activity can be studied by analysis of the urinary markers of eumelanin (6-hydroxy-5-methoxyindole-2-carboxylic acid, 6H5MI-2-C) and phaeomelanin (5-S-cysteinyl-dopa, 5-S-CD). To determine whether chloroquine inte

Why liquid membrane extraction is an attractive alternative in sample preparation

The use of liquid membrane-based extractions is increasingly seen as offering an alternative to conventional sample preparation procedures in analysis of chemical species in both environmental and biological media. In this article, emphasis is placed on the attractiveness of liquid membrane-based extraction techniques to a variety of analytical applications such as speciation of metal ions in biol

Structural basis for SH2D1A mutations in X-linked lymphoproliferative disease

X-linked lymphoproliferative disease (XLP) is a rare and severe immune deficiency, characterized by abnormal immune responses to the Epstein-Barr virus. Recently, the gene responsible for XLP, SH2D1A, has been identified and shown to code for a small cytoplasmic protein with an SH2 domain that interacts with SLAM and 2B4, two receptorial molecules involved in signal transduction in T and NK cells,

Potential cardioembolic sources in an elderly population without stroke. A transthoracic and transoesophageal echocardiographic study in randomly selected volunteers

Transoesophageal echocardiography renders a better image than transthoracic echocardiography of cardiac changes especially at the atrial level, and of atherosclerotic changes in the aorta. Although several studies on stroke patients have included transthoracic and transoesophageal echocardiography, the relevance of the reported findings remains unclear because of limited information on the prevale

Swedish men's experiences of becoming fathers to their preterm infants

PURPOSE: To describe Swedish men's experiences of becoming fathers to their preterm infants. DESIGN: A cross-sectional descriptive study. SAMPLE AND METHOD: Eight men participated in semistructured interviews with open-ended questions. The interviews were analyzed using manifest and latent content analysis. MAIN OUTCOME VARIABLES: The concepts of control and noncontrol. RESULT: The manifest analys

Hereditary prostate cancer: clinical aspects

PURPOSE: We review the current epidemiological and genetic knowledge regarding hereditary prostate cancer, and outline its clinical implications. MATERIALS AND METHODS: Published articles on hereditary prostate cancer were identified using the MEDLINE data base. RESULTS: A risk of prostate cancer, particularly early onset disease, is strongly affected by family history (number of relatives with pr

Fabrication and Characterization of a Thin-Layer Electrochemical Flow Cell and Its Application for Flow Analysis

The design and fabrication of a home-made thin-layer electrochemical flow cell are reported. The performance and electrochemical characteristics of thin-layer cells are evaluated in terms of flow rate and channel thickness. The adaptability of the flow cell for amperometric and electrochemiluminescence measurements is demonstrated. Also, a flow injection method comprising electrochemical generatio

Registered nurses' perceptions of conditions for patient education - focusing on aspects of competence

Background: It is important to clarify nurses' perceptions of conditions for patient education in daily work as research findings are ambiguous. There is a gap between societal regulations on nurses' competence in accomplishment/achievement of patient education and research findings. Aim: The aim was to describe nurses' perceptions of conditions for patient education, focusing on aspects of compet