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Messenger RNA (mRNA) vaccines based on lipid nanoparticles (LNPs) are stabilized with cholesterol, which is thought to be a critical LNP component because it is essential for membrane integrity and endosomal escape. Here, it is shown that cholesterol in LNPs can be replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C-type lectin receptor agonist monomycoloyl glycerol (MMG

This paper proposes a conceptual model of decision-making tying specific preferences to broader individual goals. Specifically, we consider terminal goals, representing fundamental objectives, and instrumental goals, serving as complexity-reducing intermediate steps toward achieving terminal goals and determining eventual preferences. Notably, the hierarchical goal structure allows for contextual

The invention pertains to a process for preparing a random co- poly(hydroxycarbonate) comprising reacting a 6-membered di-cyclic carbonate with a polyol, or a monohydric alcohol, via a ring-opening polymerization (ROP) by catalytic control for carbonate unit formation, in the presence of a catalyst, through a ring- opening polymerization reaction. Also, the invention pertains to a random co- poly(

Poor acoustic conditions in learning spaces have a detrimental effect on the speaker's health and constitute a risk factor for voice disorders. Previous research indicates that an acoustic refurbishment of the learning space has the potential to increase well-being and decrease voice-related health problems among teachers, but the research is scarce. In this study, we aim to investigate how differ

In the last three field seasons the Geological Survey of Denmark and Greenland (GEUS) has undertaken mapping in the south-eastern part of the Nuuk region in southern West Greenland, and here we present new zircon ages that help constrain the northern boundary of the Tasiusarsuaq terrane. The Archaean geology of the Nuuk region is commonly interpreted as a tectonic collage assembled through lateral

The classical Chinese poem Mulan Shi has been translated many times into different languages and adapted to different media. Drawing upon Sonesson’s definition of translation as a double act of communication and combining it with concepts from narratology and translation theory, we develop a framework comprising three levels of translation resemblance: (a) between the structure and content of the

The concept of scattering contrast is central to (small-angle) scattering of neutrons, X-rays, and visible light, as it defines the visibility to the radiation of the nano- and mesostructures under scrutiny, in their respective solvent or matrix. In this chapter, we start with the scattering process by elementary scatterers, such as nuclei or atoms, which produce secondary, scattered waves, and th

The Sörvik granite forms rounded intrusions in the dominating Revsund granite, north-eastern Jämtland, central Sweden. Laser-ablation single-collector magnetic sector field-inductively coupled plasma-mass spectrometry on zircons was used to date the granite. The zircons are inhomogeneous, some with evident cores. The fractionation curves, 207Pb/235U versus time (depth), are irregular and often inc

Upper-intercept U-Pb ages (TIMS) of two non-foliated I-type granites are 1887 ± 20 Ma (part of a granodiorite-granite sequence) and 1881 ± 2 Ma (leucogranite with transitions into pegmatite). A non-foliated S-granite, which according to field observations, is younger than the two I-granites, occurs within the same composite pluton. Zircons of this granite are heterogeneous and contain abundant cor

Distributed multiple-input multiple-output (MIMO), also known as cell-free massive MIMO, has emerged as a promising technology for sixth-generation (6G) wireless networks. This letter introduces an indoor channel measurement campaign designed to explore the behavior of multipath components (MPCs) in distributed MIMO channels. Fully coherent channels were measured between eight distributed uniform

The l’Hort de la Boquera site is located in the northeastern part of Iberia and its stone tool assemblage includes up to 25,000 flint artefacts. This is the first approach to the analysis of the raw material through an archaeopetrological study. Results were obtained by use of mineralogical techniques: macroscopic and petrographic analysis, Scanning Electronic Microscopy (SEM), Micro-Raman and X-R

The rapid advancement of medicine, fueled by big data and interdisciplinary research, has significantly transformed the landscape of computational oncology research. In this evolving environment, effective time management strategies are essential for researchers across diverse specializations. Computational oncology researchers typically pursue one of three primary career paths: clinical medicine,

Wheat (Triticum aestivum L.) is a major crop grown on all continents. Due to environmental concerns, it is desirable to reduce the inputs of both chemical pesticides and inorganic fertilizers. However, yield reduction must be expected when switching to low-input systems. To mitigate such losses, the use of natural or introduced microbiomes may provide the key to maintaining sustainable yield. Phyl

The invention pertains to a process for preparing a random co-poly(urethane-carbonate) comprising reacting a 6-membered di-cyclic carbonate with a polyamine via a ring- opening polymerization (ROP) by catalytic control for carbonate unit formation, in the presence of a catalyst, through a ring-opening polymerization reaction. Also, the invention pertains to a random co-poly(urethane-carbonate) bei

Illegal, unreported, and unregulated (IUU) fishing poses a serious threat to marine biodiversity and economic stability, particularly in coastal nations like Malaysia, where the smuggling of government-subsidized fuel is often linked to IUU activities. This study presents a forensic approach using gas chromatography-flame ionization detection (GC-FID) and gas chromatography-mass spectrometry (GC–M

Tonalite-trondhjemite–granodiorite (TTG) gneisses and melanocratic to ultramafic greenstones dominate the Archaean basement of southern West Greenland. The greenstones are likely to represent different original environments, which is important as the mineral deposits they may host depend on this. For example, massive sulphide deposits associated with gold and base metals are commonly volcanogenic,

The extensive and very deep ?Jurassic/Cretaceous–Palaeogene sedimentary basins offshore West Greenland have a significant petroleum exploration potential. This is particularly true for the offshore region west of Disko and Nuussuaq where a live petroleum system has been documented for many years. At present, stratigraphic knowledge in this area is almost nonexistent and analogue studies from onsho

During the field campaign in the Nuuk region, one of the objectives was to describe Archaean primary geological environments (Hollis et al. 2006). On Nunatak 1390, which is part of the Tasiusarsuaq terrane (Figs 1, 2), a bimodal volcanic succession is preserved and interpreted as former ocean floor. The field investigation included geological mapping and sampling of the volcanic sequence comprisin