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Methods for isolation and transcriptional profiling of individual cells from the human heart

Background: Global transcriptional profiling of individual cells represents a powerful approach to systematically survey contributions from cell-specific molecular phenotypes to human disease states but requires tissue-specific protocols. Here we sought to comprehensively evaluate protocols for single cell isolation and transcriptional profiling from heart tissue, focusing particularly on frozen t

Bioartificial lungs based on de- and recelluarisation approaches: a historical perspective.

For patients with end-stage respiratory diseases, such as COPD, interstitial lung diseases and cystic fibrosis, lung transplantation remains the only treatable option. However, due to increasing demand and limited availability of donor lungs, risk of complications such as acute and chronic rejection, and adverse effects of immunosuppressive treatments, this is not an alternative for the majority o

Orphan G-protein coupled receptor 183 (GPR183) potentiates insulin secretion and prevents glucotoxicity-induced β-cell dysfunction

The expression and functional impact of most expression orphan G-protein coupled receptors (GPCRs) in β-cell is not fully understood. Microarray expression indicated that 36 orphan GPCRs are restricted in human islets, while 55 receptors overlapped between human islets and INS-1 cells. GPR183 showed higher expression in diabetic compared to non-diabetic human islets. GPR183 expression co-localized

Phosphorylation of human AQP2 and its role in trafficking

Human Aquaporin 2 (AQP2) is a membrane-bound water channel found in the kidney collecting duct whose regulation by trafficking plays a key role in regulating urine volume. AQP2 trafficking is tightly controlled by the pituitary hormone arginine vasopressin (AVP), which stimulates translocation of AQP2 residing in storage vesicles to the apical membrane. The AVP-dependent translocation of AQP2 to a

Composite Adaptive Control for Bilateral Teleoperation Systems without Persistency of Excitation

Composite adaptive control schemes, which use both the system tracking error and the prediction error to drive the updating law, have become widespread in achieving an improvement of system performance. However, a strong persistent-excitation (PE) condition is required to guarantee the convergence of the parameter estimation errors. This paper proposes a novel composite adaptive control for nonlin

Teaching Control Principles to Industry Practitioners

This paper addresses the need of continued education of process industry practitioners such as operators and instrumentation engineers. The process industry regulatory control tuning situation of today is reviewed. Areas of potential improvement are identified. A course, aimed at fulfilling these needs is presented. Especially, useful laboratory experiments are outlined. The suggested course was g