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Objectives: In axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) patients initiating secukinumab, we aimed to assess retention rates and proportions of patients achieving remission and low disease activity (LDA), according to disease activity measures and patient-reported outcomes at 24 and 48 months. Patients and methods: Data on patients with axSpA and PsA who initiated secukinumab t

In recent decades, ethicists have engaged with new developments in human reproductive technologies from a variety of angles. Yet there has been relatively little effort to problematize the concept of reproduction itself. In this paper, we examine the question of what reproduction is and its relationship with biology. We show that reproduction is commonly assumed to entail biological parenthood—an

Purpose: Use of mechanical imaging (MI) as complementary to digital mammography (DM), or in simultaneous digital breast tomosynthesis (DBT) and MI - DBTMI, has demonstrated the potential to increase the specificity of breast cancer screening and reduce unnecessary biopsies compared with DM. The aim of this study is to investigate the increase in the radiation dose due to the presence of an MI sens

Steadily increasing use of computer-generated models sets high demands on the realistic representation of breast tissue and abnormalities. Previously, we demonstrated the use of Perlin noise to simulate breast lesions. Now, we expand the previous model by simulating heterogeneous lesion composition. We demonstrate a new approach to simulating 3D soft tissue lesions, with additional benefits of Per

This thesis develops an ethical framework called the ethics of authenticity and puts it to work through concrete engagement with seven contemporary Scandinavian films. It starts by tracing the contradictory developments of modern freedom, highlighting the tensions of freedom and solidarity and how this comes to the fore in ethics, politics and film aesthetics. Inspired by Simone de Beauvoir’s exis

2,5-Furandicarboxylic acid (FDCA) is a promising building block for biobased recyclable polymers and a platform for other potential biobased chemicals. The common route of its production is by oxidation of sugar-derived 5-hydroxymethylfurfural (HMF). Several reports on biocatalytic oxidation using whole microbial cells or enzymes have been reported, which offers potentially a greener alternative c

Recent research in evolutionary economic geography addressing radical innovation and grand challenges has advocated for a shift in focus from single technologies and products toward interrelated configurations of technologies and institutions. This suggests moving beyond explaining innovation and industrial dynamics primarily by the existence of appropriate knowledge and capability stocks, to incl

Public relations professionals’ use of generative artificial intelligence (GenAI) tripled during 2023. Despite this surge, there is a notable lack of in-field studies examining GenAI and other CommTech implementation in public relations. To address this research gap, we adopt the view of the digital transformation of public relations as a socio-technical change process and explore how a communicat

Demonstrating how strategic communication management creates value has long been considered a key challenge for communication departments and managers. Theorizing and explaining how strategic communication creates value and how this value can be demonstrated has, therefore, emerged as a central research concern in public relations and strategic communication. While extant literature acknowledges t

This chapter has a twofold aim. Our first aim is to argue for a shift from viewing engagement as a psychological state to understanding it as a communication phenomenon inherently embedded in relational and interactive processes. We argue that as a communication phenomenon, engagement is best captured in the broader meaning of the verb engage, that is, “to begin and carry out an […] activity”. Whe

In this paper, an inventory model with finite and constant replenishment rate, price dependant demand rate, time value of money and inflation, finite time horizon, lead time and exponential deterioration rate and with the objective of maximizing the present worth of the total system profit is developed. Using a dynamic programming based solution algorithm, the optimal sequence of the cycles can be

Background: Arterial stiffness, measured using carotid-femoral pulse wave velocity (c-f PWV) and heart rate-corrected augmentation index (Aix75), is associated with cardiovascular disease, and in some studies incident atrial fibrillation (AF). In this cross-sectional study, we aimed to investigate whether arterial stiffness is associated with markers of atrial myopathy, which refers to structural

The circular economy is becoming a globalised phenomenon, but the regional emergence of circular business models differs significantly. By adopting a circular business institutionalisation perspective which bridges theory on institutional work and “ecologies of business models” we study the emergence of circular business models in Japan, a region with recent circular policy and business commitment

Diffusion models were initially developed for text-to-image generation and are now being utilized to generate high quality synthetic images. Preceded by generative adversarial networks (GANs), diffusion models have shown impressive results using various evaluation metrics. However, commonly used metrics such as Frechet inception distance and inception score are not suitable for determining whether

Purpose: Volumetry of cerebral ventricles is a far more sensitive measure for shunt-induced reduction of ventricular size than traditional 2-dimensional (2D) measures, such as Evans index. However, available ventricle segmentation methods are time-consuming, resulting in limited use in clinical practice. Quantitative MRI (qMRI) obtains objective measurements of physical tissue properties, enabling