RNAseq-based transcriptome profiling of the Engrailed-1 mouse model of Parkinson’s Disease
Background | Motor dysfunction due to progressive nigrostriatal degeneration is a key feature of Parkinson’s disease (PD). Hemizygous loss of Engrailed-1 (En1) induces features reminiscent of PD in mice, such as nigrostriatal axonal degeneration and dopaminergic neuron death in the substantia nigra pars compacta (SNpc) starting at three weeks of age. Interestingly, the neuropathological phenotype
