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En tredjedel av Sveriges befolkning drabbas av cancer någon gång i livet. När cancerbehandlingar misslyckas beror det oftast på att cancercellerna har utvecklat resistens mot cellgifter eller spridit sig i kroppen och bildat dottertumörer. De senaste årtiondena har forskare intresserat sig för vissa typer av cancerceller som har en extra drivkraft att bilda nya tumörer och sprida sig i kroppen. SåCancer stem cells are a subpopulation of cells that possess an increased tumorigenic potential. Such cells are connected to drug resistance, metastasis, and cancer recurrence. In 2009, the polyether ionophore salinomycin was shown to exhibit selective activity against cancer stem cells. At the outset of the studies described in this thesis, few salinomycin analogs had been reported and it was not

Infantile malignant osteopetrosis (IMO) is a rare, recessive disorder characterized by increased bone mass caused by dysfunctional osteoclasts. The disease is most often caused by mutations in the TCIRG1 gene encoding a subunit of the V-ATPase involved in the osteoclasts capacity to resorb bone. We previously showed that osteoclast function can be restored by lentiviral vector-mediated expression

Most current research argues that globalization of companies is a myth. In spite of this Swedish firms have managed to globalize successfully according to a study by Vahlne and Ivarsson (2014). On a general level this is because they managed to build strong advantages and learned to overcome barriers constituted by cultural, institutional and geographic distance. We elaborate on the expectation th

Such types of violence seem to emanate from what I would call supremacist resentment, which is driven by the perceived superiority of a given race, ethnicity or nationality over another and which motivates attempts to sabotage “subaltern” success or hinder a supposedly inferior subject from climbing up the social-institutional ladder.

Comment on De la Cadena, Marisol. 2015. Earth beings: Ecologies of practice across Andean worlds. Durham, NC: Duke University Press.

For several centuries, the dominant worldview in industrial societies has held that various problems --such as those recently identified as relating to sustainability-- can be solved through technological progress. Technological progress has been conceived as the fruits of engineering science, new knowledge, and innovation. While knowledge of the principles of physics is certainly a necessary cond

To gain more insight into evidentiality, the grammatical marking of information source, it is worth studying the category in its relation to other grammatical categories. This study explores tensed evidentials, morphemes in which tense and evidentiality are fused, in 36 languages from four macro-areas (North America, South America, Eurasia, and Papunesia). The study reveals several interactions be

Although most definitions of hypnosis consider inductions as the initial stage in a hypnosis protocol, knowledge of inductions remains poor and uninformed by recent developments in theory and research. It is frequently argued that inductions play a critical role in hypnotic responding or, by contrast, are largely interchangeable and unimportant. Drawing on the literature on suggestibility, spontan

This thesis consists of five papers within the design and analysis of efficient algorithms.In the first paper, we consider the problem of computing all-pairs shortest paths in a directed graph with real weights assigned to vertices. We develop a combinatorial randomized algorithm that runs in subcubic time for a special class of graphs.In the second paper, we present a polynomial-time dynamic progThis thesis consists of five papers within the design and analysis of efficient algorithms.In the first paper, we consider the problem of computing all-pairs shortest paths in a directed graph with real weights assigned to vertices. We develop a combinatorial randomized algorithm that runs in subcubic time for a special class of graphs.In the second paper, we present a polynomial-time dynamic prog

A commonly held view is that strategic organization theories progress as a result of a Popperian process of bold conjectures and systematic refutations. However, our field also witnesses vibrant debates or disputes about the specific assumptions that our theories rely on, and although these debates are often decoupled from the results of empirical testing, changes in assumptions seem closely inter

This essay reflects on the ”-ology of technology”, pace Brian Arthur (2009), as conveyed in theformal (i.e. mathematical) treatment of technology and innovation in economic theory. In thedecades from the 1970s economists of the evolutionary strand have levied criticism on the way inwhich technology is handled in mainstream economics. Some of this criticism has concerned theassumptions made in part

This thesis describes experiments involving laser-plasma-based acceleration of electrons and protons, using the techniques of laser wakefield acceleration (LWFA) and target normal sheath acceleration (TNSA). By using extremely high accelerating field strengths, up to the order of TV m-1, it is possible to reach high kinetic particle energies over very short distances.The multi-terawatt laser syste