Influence of FK506 on certain aspects of lymphocyte activation and lymphocyte-endothelial cell interactions in vitro
In the present thesis, the influence of the immunosuppressive drug FK506 on mitogen-induced changes in the expression of subunits a and ß of the IL-2 receptor by isolated human peripheral blood mononuclear cells has been studied. Up-regulation and release of the a-chain were potently depressed by FK506, even in the presence of exogenous IL-2. In contrast, up-regulation of the ß-chain on these same
