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Large cell carcinoma with or without neuroendocrine features (LCNEC and LC, respectively) constitutes 3-9% of non-small cell lung cancer but is poorly characterized at the molecular level. Herein we analyzed 41 LC and 32 LCNEC (including 15 previously reported cases) tumors using massive parallel sequencing for mutations in 26 cancer-related genes and gene fusions in ALK, RET, and ROS1. LC patient

Verkstadsmaterial från vendeltid från östra Skåne. En ansamling näbbfibulor, uppenbarligen inte färdiga. Materialet är att uppfattas om ett verkstadslager. Ger inblickar i tillverkningsprocess och regionala hantverkstraditioner.

Background: The incidence of non-Hodgkin lymphoma (NHL) in early life has increased in recent decades, but the relevant risk factors remain largely unknown. We examined perinatal and family risk factors for NHL in childhood through young adulthood. Methods: We conducted a national cohort study of 3 571 574 individuals born in Sweden in 1973-2008 who were followed for incidence of NHL through 2009

Kan barndomens häpnad över ”märkvärdiga ting” påverka våra vuxna värderingar? För inte så länge sedan – ännu i mannaminne – visades exotiska folkslag på cirkus. Färgar detta första möte med det annorlunda vår människosyn?

Shredder residues of end-of-life vehicles and white goods are a complex waste stream, which nowadays most often is disposed of at industrial landfills. This paper describes the most important findings concerning the complex composition of the landfill leachate and its on-site, year-round treatment under cold-climate conditions. A 3-year investigation has confirmed that concentrations of different

In this study, a new supercritical fluid chromatography-mass spectrometry (SFC-MS) method has been developed for the separation of nine vitamin D metabolites within less than eight minutes. This is the first study of analysis of vitamin D and its metabolites carried out by SFC-MS. Six columns of orthogonal selectivity were examined, and the best separation was obtained by using a 1-aminoanthracene

Since 2009, Japanese civil society groups have arranged exhibitions in China dealing with the so-called comfort women issue in cooperation with local Chinese organizers, including state-run war museums that function as patriotic education bases. Organizing these exhibitions has required much time and energy. A fundamental aim of these groups is to make the Japanese government compensate the victim

In order to reduce its environmental impact, the chemical industry no longer produces base chemicals such as ethylene, solely from fossil, but also from biomass-based feedstocks. However, a biomass option suitable for one region might not be as suitable for another region due to, e.g., long transport and the related environmental. Therefore, local biomass alternatives and the environmental impact

This paper concerns the use of the expectation-maximisation (EM) algorithm for inference in partially observed diffusion processes. In this context, a well known problem is that all except a few diffusion processes lack closed-form expressions of the transition densities. Thus, in order to estimate efficiently the EM intermediate quantity we construct, using novel techniques for unbiased estimatio

The article considers the importance of frontier studies in historical archaeology and discusses applicability of some of the concepts deriving from postcolonial theories for a better understanding of human relationships in the frontier zones. The conditions of frontiers and borderlands are compared with the characteristics of the “Third Space” described by Homi Bhabha as a realm of negotiation, t

Widespread implementation of cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) in clinical settings requires improved accuracy for diagnosis of prodromal disease and for distinguishing AD from non-AD dementias. Novel and promising CSF biomarkers include neurogranin, a marker of synaptic degeneration, and YKL-40, a marker of neuroinflammation.

In this paper, a novel method for analysing a bird’s song is presented. The song of male great reed warblers is used for developing and testing the methods. A robust method for detecting syllables is proposed and a classification of those syllables as compared to reference syllables is done. The extraction of classification features are based on the use of singular vectors in different time-freque

This thesis covers different topics related to the application of pseudospectral optimization methods in the field of automatic control. Pseudospectral optimization methods solve dynamic optimization problems by discretizing the state-space, creating a discretized version of a continuous problem. The resulting discretized optimization problems are solved by standard software for nonlinear optimiza

Background In mild asthma exercise-induced bronchoconstriction (EIB) is usually treated with inhaled short-acting beta(2) agonists (SABAs) on demand. Objective The hypothesis was that a combination of budesonide and formoterol on demand diminishes EIB equally to regular inhalation of budesonide and is more effective than terbutaline inhaled on demand. Methods Sixty-six patients with asthma (>12 ye