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A cDNA coding for human sex hormone binding globulin. Homology to vitamin K-dependent protein S

Affinity purified antibodies to human sex hormone binding globulin (SHBG) were used in screening a human liver cDNA library, constructed in the expression vector lambda gt11. One clone, identified as producing recombinant SHBG, carried a cDNA insert of 1.1 kb. The nucleotide sequence of the insert had an open reading frame coding for 356 amino acid residues. The coding sequence was followed by a s

A Scalable Formulation for Engineering Combination Therapies for Evolutionary Dynamics of Disease

It has been shown that optimal controller synthesis for positive systems can be formulated as a linear program. Leveraging these results, we propose a scalable iterative algorithm for the systematic design of sparse, small gain feedback strategies that stabilize the evolutionary dynamics of a generic disease model. We achieve the desired feedback structure by augmenting the optimization problems w

Tänk om det är precis tvärtom!?

Dominerande medicinsk forskning säger att kolesterolhalten i blodet är en potent riskfaktor för hjärt-kärlsjukdom. Ju lägre kolesterol, desto bättre! brukar man säga. Parallellt med detta finns studier som hävdar att denna kolesterolhypotes är förknippad med många frågetecken. Den i Sverige mest kände kolesterolkritikern Uffe Ravnskov, har nyligen givit ut boken The Cholesterol Myths. Professor Bo

Analysis of multiphase tranport phenomena in PEMFCs by incorporating microscopic model for catalyst layer structure

The catalyst layer (CL) in polymer electrolyte membrane (PEM) fuel cells is one of the key components regulating the overall performance of the cell. In PEM fuel cells, there are two CLs having identical composition for hydrogen oxidation (HO) and oxygen reduction (OR) reactions. There are four phases inside the CL, namely: carbon, Pt particles, ionomer and voids. In this work, a micro-model of th