A1M, Hb and tryptophan metabolism in R6/2 mouse model of Huntington’s disease
Neurotoxic metabolites generated from tryptophan metabolism are increasingly regarded as a pathogenic mechanism in neurological and psychiatric disease including Huntington’s disease (HD). Specifically, the tryptophan-derived neurotoxin 3-hydroxykynurenine (3-HK) accumulates in HD brain and is capable of damaging neurons through excessive ROS-production and oxidative stress. The protein A1M, alpha
