The endothelin type B receptor (ETB or EDNRB) is highly plastic and is upregulated in smooth muscle cells (SMCs) by arterial injury and following organ culture in vitro. We hypothesized that this transcriptional plasticity may arise, in part, because EDNRB is controlled by a balance of transcriptional inputs from myocardin-related transcription factors (MRTFs) and ternary complex factors (TCFs). W

Results from previous research suggest that the ability to manage ambiguous problems during acute emergency and disaster management is a desirable quality among decision-makers. Ambiguity is a perception that arises when the problem-solver is dissatisfied with his or her understanding of the structure of the problem, and consequently of the problem-solving process. This article presents the result

JavaScript is a dynamically typed and object-based scripting language with runtime evaluation. It has emerged as an important language for client-side computation of web applications. Previous studies have shown differences in behavior between established JavaScript benchmarks and real-world web applications. However, there still remains several important aspects to explore. In this paper, we comp

Precis som för bilindustrin, investeras stora belopp på att skapa obemannade fartyg. De huvudsakliga fördelarna är att säkerheten förväntas förbättras, vinsternakommer att öka, samt att utsläppen kommer att minska. Helt autonoma fraktfartyg förväntas kunna korsa Atlanten helt obemannat innan år 2030, och fram tillsdess förväntas tekniken gradvis förbättra säkerheten och ersätta arbetsuppgiftersom As for the automotive industry, large efforts are being made by industry andacademia to create autonomous ships. Te solutions for this is very technologyintense, as many building blocks, often relying on AI technology, need to worktogether to create a complete system that is safe and reliable to use. Even whenthe ships are fully unmanned, humans are still foreseen to guide the ships whenunknown si

Atopic dermatitis (AD) is a clinically defined, highly pruritic, chronic inflammatory skin disease of children and adults. The diagnosis is made using evaluated clinical criteria. Disease activity is best measured with a composite score assessing both objective signs and subjective symptoms, such as SCORAD. The management of AD must consider the clinical and pathogenic variabilities of the disease

IMPORTANCE The extent to which large-caliber axonal degeneration contributes to Alzheimer disease (AD) progression is unknown. Cerebrospinal fluid (CSF) neurofilament light (NFL) concentration is a general marker of damage to large-calibermyelinated axons. OBJECTIVE To test whether CSF NFL concentration is associated with cognitive decline and imaging evidence of neurodegeneration and white matter

Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular complications (including retinopathy, nephropathy and neuropathy) and macrovascular complications (such as cardiovascular comorbidities), owing to hyperglycaemia and individual components of the insulin resistance (metabolic

Many primary care professionals manage injection or infusion therapies in patients with diabetes. Few published guidelines have been available to help such professionals and their patients manage these therapies. Herein, we present new, practical, and comprehensive recommendations for diabetes injections and infusions. These recommendations were informed by a large international survey of current

Breathlessness that persists despite treatment for the underlying conditions is debilitating. Identifying this discrete entity as a clinical syndrome should raise awareness amongst patients, clinicians, service providers, researchers and research funders.Using the Delphi method, questions and statements were generated via expert group consultations and one-to-one interviews (n=17). These were subs

Sponge city construction can improve cities’ ability to adapt to the environment change and the ability to cope with floods, and it can also prompt cities’ development to be more healthy and sustainable. However, the process itself of sponge city construction may also has impact on the environment especially in built-up areas, to reduce the impact, the rainwater landscape design needs to integrate

Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β-amyloid peptides (Aβ), while NFTs contain hyperphosphorylated tau proteins. Patients with familial AD who have mutations in the amyloid precursor protein (APP) gene have either increased production of Aβ or generate more aggregation-pron

In this tutorial paper we first present some foundational results regarding the theory of positive systems. In particular, we present fundamental results regarding stability, positive realization and positive stabilization by means of state feedback. Special attention is also paid to the system performance in terms of disturbance attenuation. Under the asymptotic stability assumption, such perform

A performance-based approach is developed for adaptive robust control of linear systems with uncertain parameters. The dual control objective involves the disturbance attenuation and worst case identification of the unknown parameters. The proposed synthesis procedure relies on sufficient conditions, given in terms of suitable solutions of perturbed differential Riccati equations to exist. Althoug

Changes in the inlet morphology of choked coastal lagoons often restrict the water exchange with the sea, making them vulnerable to pollution release and eutrophication processes. In this study, the role of tides for the water exchange was investigated in a choked lagoon for critical scenarios during the low river flow season. Both an integrated and spatially distributed approach were employed usi

This article discussed the history of the position of the married woman in Dutch personal income tax law in its historical, juridical en social-cultural background. From 1892-1984 married women were in fact tax transparent in the Netherlands

A recent naturalistic epistemological account suggests that there are three nested basic forms of knowledge: procedural knowledge-how, conceptual knowledge-what, and propositional knowledge-that. These three knowledge-forms are grounded in cognitive neuroscience and are mapped to procedural, semantic, and episodic long-term memory respectively. This article investigates and integrates the neurosci