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Basic analysis of a potential carrier includes calculation of the probability, or odds, for carriership based on pedigree and clotting factor analysis. Genotype assessment constitutes a more accurate method of carrier detection. Where circumstances permit, the genetic diagnosis of hemophilia should be based on the direct identification of the pathogenic mutation in the factor (F) VIII gene. Neutra
Two acid deposition scenarios were simulated for six European forest sites situated in Germany, Denmark, Russia, Switzerland, Spain and Ireland. Three models were used in combination; the RAINS (Regional Acidification INformations and Simulation) model, the SAFE (Simulating Acidification in Forest Ecosystems) model and the MakeDep model. The scenarios used were based on results from international
The Auger-Doppler effect in the experimental spectra of HF and DF is presented. and the dynamics of ultra-fast dissociation in the core-excited state are discussed. The Doppler splitting of the atomic Auger peak is calculated and simulated using a classical model and a very good agreement is found between experiment and simulation. It is shown that the difference in photon energy relative to the r
1. The dilator effect of extracellular adenosine triphosphate (ATP) has mainly been characterized as a direct effect on smooth muscle or as an endothelium-dependent effect mediated by nitric oxide (NO) or prostaglandins. We tested the hypothesis that endothelium-derived hyperpolarizing factor (EDHF) may also be involved. Dilator effects were studied in vitro by continuous recording of isomeric ten
Photon-echo-based devices have been proposed for many applications in data storage, image processing, and optical communications. Many of these applications would benefit if the output from the photon-echo process could be used as input in a second photon-echo process. We demonstrate the generation of such secondary echoes, using the amplified output from an initial photon-echo process. The amplif
This article is an overview of the various aspects characterizing the interjection - probably the most controversial linguistic unit in the history of grammatical tradition and modern linguistics - as Latin grammarians outlined them, especially in the postclassical and late antiquity. The corpus employed for the purposes of this study is Henricus Keil's Grammatici Latini, a most valuable and uniqu
Introduction of the xylose pathway from Pichia stipitis into Saccharomyces cerevisiae enables xylose utilization in recombinant S. cerevisiae. However, xylitol is a major by-product. An endogenous aldo-keto reductase, encoded by the GRE3 gene, was expressed at different levels in recombinant S. cerevisiae strains to investigate its effect on xylose utilization. In a recombinant S. cerevisiae strai
Popular Abstract in Swedish Patienter med kroniskt obstruktiv lungsjukdom, KOL, har en försämrad lungfunktion och lider av bronkit och andnöd. Dessa symptom beror troligtvis på en ständigt pågående inflammation i lungan som dels leder till ökad slemproduktion och förträngning av luftrören, dels till emfysem dvs. nedbrytning av lungvävnaden vilket försämrar gasutbytet i lungan. Cigarrettrökning är Chronic obstructive pulmonary disease, COPD, is manifested by chronic airflow limitation due to inflammation and tissue destruction in the lungs. COPD is caused primarily by smoking and with increasing cigarette consumption in the world, the prevalence for COPD will most probably increase in the future. The chronic inflammation in the lungs of these patients is thought to drive the pathogenesis fo
I föreliggande rapport redovisas en fördjupad studie av hur en vattenavvisande impregnering fungerar när det finns sprickor i fasaden.
The relation between the isoform distribution of the myosin 17 kDa essential light chain (LC17) and the mechanical properties of smooth muscle was investigated. The relative content of the basic (LC17b) and acidic (LC17a) isoelectric variants of the 17 kDa myosin light chain was determined in different mammalian smooth muscle tissues. The relative content of LC17b varied between muscles: rabbit re
Randomized, double-blind, controlled studies have shown that treatment with risedronate reduces the risk of vertebral fracture in postmenopausal women with established vertebral osteoporosis. They also show that the drug decreases the risk of non-vertebral fractures in women with osteoporosis. The aim of this study was to investigate the cost-effectiveness of risedronate in postmenopausal women wi
Histologic grade, including tubular formations, nuclear grade, and mitotic activity, is a well-documented prognostic factor in breast cancer. In comparison with other prognostic parameters, the evaluation of histologic grade is cheap and can be performed, in principle, in all cases of breast cancer. One possible disadvantage is that the evaluation may vary between different pathological department
Phosphodiesterase 3B (PDE3B), is known to play an important role in acute insulin and cAMP-mediated regulation of lipid metabolism, and PDE4 are the main PDE types expressed in adipocytes. Here, we show that members of all PDE4 isoforms are expressed in 3T3-L1 and primary mouse adipocytes. Long-term treatment of 3T3-L1 adipocytes with insulin induced up-regulation of PDE3B and PDE4D in a phosphati
