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Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils

The deposition of coassemblies made of the small presynaptic protein, α-synuclein, and lipids in the brains of patients is the hallmark of Parkinson's disease. In this study, we used natural abundance 13C and 31P magic-angle spinning nuclear magnetic resonance spectroscopy together with cryo-electron microscopy and differential scanning calorimetry to characterize the fibrils formed by α-synuclein

A pilot study of hypertension management using a telemedicine treatment approach

We recruited 78 men and 94 women to investigate if the proportion of subjects with well-controlled home blood pressure levels could be increased when treatment was guided by smartphone-based telemonitoring. All patients were prescribed one to three antihypertensive drugs. The Accumbo smartphone telemonitoring application was downloaded to the Iphones of the participants and home blood pressure inf

Data centres in future European energy systems—energy efficiency, integration and policy

End-use efficiency, demand response and coupling of different energy vectors are important aspects of future renewable energy systems. Growth in the number of data centres is leading to an increase in electricity demand and the emergence of a new electricity-intensive industry. Studies on data centres and energy use have so far focused mainly on energy efficiency. This paper contributes with an as

Fatalism and Dissidence in Dukuduku, KwaZulu-Natal, South Africa : Ongoing Contestations Over Land, Resources and Identities

This article explores the use of identity politics in conflicts that pertain to land, land restitution and traditional authority in northern KwaZulu-Natal, South Africa, and more specifically the Dukuduku area. Under the influence of past geographic displacements, ongoing neoliberal transformations and the transition to democracy under the post-apartheid government, not least including contested t

Block copolymers as bile salt sequestrants : Intriguing structures formed in a mixture of an oppositely charged amphiphilic block copolymer and bile salt

To study the formation and characterize the structure of mixed complexes of oppositely charged block copolymers and surfactants are of great significance for practical applications, e.g., in drug carrier formulations that are based on electrostatically assisted assembly. In this context, biocompatible block copolymers and biosurfactants (like bile salts) are particularly interesting. In this work,

Librarian-academic collaboration: the role of strategic communication and relationship management

Information literacy and critical thinking skills are essential in the information age towards achieving academic success and being adequately skilled for lifelong learning. Academic libraries have an indispensable role to play in this regard. Collaboration between librarians and academics is important to ensure both effective information-literacy training and service provision to students and to