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Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease.

BACKGROUND: Adverse drug reactions are a significant reason for therapeutic failure during thiopurine treatment of inflammatory bowel disease. Some smaller series in this patient population have shown that a switch to mercaptopurine may be successful in many cases of azathioprine intolerance. AIM: To assess the long-term outcome of mercaptopurine treatment in a large patient population with azathi

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.

Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear. To obtain insight into this question, a panel of mouse monoclonal antibodies was generated against a major triple helical collagen type II (CII) epitope (position 359-369; ARGLTGRPGDA) with or without arginines modified by cit

Osseointegration of Titanium Implants in Onlay of Cerament™, a New Ceramic Bone Substitute.

The purpose was to investigate whether a new biphasic and injectable ceramic bone substitute Cerament™ that rapidly remodels to bone, may contribute to the retention of titanium implant screws during the healing period, and to analyze the pattern of bone formation around titanium implants.Titanium screws were implanted in rat tibiae and embedded with or without Cerament™ on the cortical surface. T

Increased rod stiffness improves the degree of deformity correction by segmental pedicle screw fixation in adolescent idiopathic scoliosis.

BACKGROUND: There are limited reports in literature studying the impact of rod diameter and stiffness on the degree of deformity correction in patients with AIS. AIMS: The aims of this study were to evaluate the 3-dimentional deformity correction achieved by segmental pedicle screw fixation in patients with adolescent idiopathic scoliosis, and to find out if learning or the change to stiffer rods

Monitoring of low molecular weight heparin anticoagulation during haemodialysis with a Sonoclot Analyzer.

Objectives: Sonoclot was used in this study to monitor low molecular weight heparin (LMWH) during haemodialysis. Material and Methods: Two different intravenous doses (standard / half-dose) of dalteparin were studied in eight patients. Blood was sampled for coagulation analyses with Sonoclot, thrombin-antithrombin (TAT) and anti-Xa. A visual fibrin deposition score (VFS) in the venous drip chamber

Using the 12-item Short Form health survey (SF-12) to measure quality of life among older people.

AIMS: To present descriptive data, study psychometric abilities, and investigate the characteristics of non-respondents to SF-12. METHOD: The study had a randomized sample (n=4278; age: 75-105) stratified in four age groups. Factor analyses were performed to investigate the factor structure of the instrument, and convergent and discriminant validity was assessed by correlation between summary scor