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Context: Insulin resistance in skeletal muscle is a major risk factor for the development of type 2diabetes in women with polycystic ovary syndrome (PCOS). Despite this, the mechanisms underlyinginsulin resistance in PCOS are largely unknown.Objective: To investigate the genome-wide DNA methylation and gene expression patterns inskeletal muscle from women with PCOS and controls and relate them to

Research on the early 20th century European and American reception of yoga ha­ve revealed the significance of esoteric movements like the Theosophical Societyin creating the modern, global phenomenon of yoga. Alongside interpretations ofyoga as primarily a form of meditation which were common in the literature and,sometimes practice, of movements like Theosophy or Thelema there exist anotherphenom

Prior research indicates that high negative emotionality in combination with low peer status is conducive of clinically identified problems in childhood. This three-wave longitudinal study examined how negative emotionality and peer status are linked over time in middle and late childhood. Participants were recruited from second grade (n = 90, mean age = 8.85) and fourth grade (n = 119, mean age =

Background: Although housing accessibility is associated with important health outcomes in other populations, few studies have addressed this in a Parkinson’s disease population. Aim: To determine the most severe environmental barriers in terms of housing accessibility problems and how these evolved over 3 years among people with Parkinson’s disease. Material and Methods: 138 participants were inc

Aresenic trioxide (ATO) is proven to be active against leukaemia cells by inducing apoptosis and differentiation. Even though ATO could effectively induce remissions of leukaemia cells, the drug resistance was observed occasionally. To further dissect the mechanism of ATO resistance, we selected the ATO-resistant SH-SY5Y cells and found that Bcl-2 controlled the sensitivity of ATO in SH-SY5Y cells

The temperature of an atmosphere decreases with increasing altitude, unless a shortwave absorber that causes a temperature inversion exists. Ozone plays this role in the Earth’s atmosphere. In the atmospheres of highly irradiated exoplanets, the shortwave absorbers are predicted to be titanium oxide (TiO) and vanadium oxide (VO). Detections of TiO and VO have been claimed using both low-, and high

Metabolism plays a central role in evolution, as resource conservation is a selective pressure for fitness and survival.Resource-driven adaptations offer a good model to study evolutionary innovation more broadly. It remains unknown howresource-driven optimization of genome function integrates chromatin architecture with transcriptional phase transitions.Here we show that tuning of genome architec

Objectives: In this study, we aimed to assess the stratification ability of the Fracture and Mortality Risk Evaluation (FAME) index for reoperation, new fragility fracture, and mortality during one-year follow-up. Patients and methods: Between November 2018 and July 2019, a total of 94 consecutive hip fragility fracture patients from two centers (20 males, 74 females; mean age: 79.3±8.9 years; ran

Den Europeiska åklagarmyndigheten (Eppo), som alldeles nyligen påbörjat sin verksamhet är en symbol för omvandlingen av unionens samarbete på det straffrättsliga området från ett mellanstatligt till ett överstatligt paradigm. Inrättandet av Eppo representerar inte bara en symbolisk handling utan är en enastående rättslig och politisk bedrift som sannolikt kommer innebära ett grundläggande systemsk

In this article the argument is made that a global court like the icc is not suitable for gaining the trust of those it rules over and that the procedure used when trying crimes against humanity is a poor fit as it is to a large extent based on national procedural codes. It is suggested that a split of the icc into several regional bodies with common procedural rules that are amended to suit the s

Background: Anorexia nervosa (AN) is a life-threatening illness. Sometimes long inpatient treatment is necessary, increasing the anxiety that comes with hospitalization and the necessary weight gain. Safe, non-pharmacological adjunctive therapies that improve subjective health are called for. Objective: The aim of this non-randomized, mixed-methods observational study was to describe the utilizati

This paper argues that the leading radical political movement in Sweden around the year 1870, whose demands included expanding the franchise, female emancipation, religious freedom, universal conscription, and abolishment of land taxes, has been partly misconstrued and misunderstood in earlier scholarship, which has characterized the New Liberals rather vaguely as ‘liberal’, ‘radical’ or ‘democrat

Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. The data on dynamics and duration of antibody response in SOTRs are limited. This longitudinal study examined the longevity of both anti-spike (S)- and anti-nucleocapsid (N)-specific IgG antibodies after COVID-19 in SOTRs compared to matched immunocompetent persons.