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The semenogelins: proteins with functions beyond reproduction?

The coagulum proteins of human semen, semenogelins I and II, are secreted in abundance by the seminal vesicles. Their function in reproduction is poorly understood as they are rapidly degraded in ejaculated semen. However, more recent results indicate that it is time to put the semenogelins in a broader physiological perspective that goes beyond reproduction and fertility.

Inhibitor development in hemophiliacs: The roles of genetic versus environmental factors

Approximately 5 to 7% of patients with hemophilia A have inhibitory antibodies to factor (F) VIII, which increases to similar to 13% in patients with severe disease. The strongest determinant of the risk of inhibitor development identified is the type of mutation in the FVIII gene that gives rise to the disease. However, accumulating evidence clearly indicates that other genetic factors (e.g., maj

Wireless Multi Hop Access Networks and Protocols

As more and more applications and services in our society now depend on the Internet, it is important that dynamically deployed wireless multi hop networks are able to gain access to the Internet and other infrastructure networks and services. This thesis proposes and evaluates solutions for providing multi hop Internet Access. It investigates how ad hoc networks can be combined with wireless and

Hydrophobic pervaporation: Influence of the support layer of composite membranes on the mass transfer

The opportunities of using hydrophobic pervaporation to concentrate organic components in aroma recovery and wastewater treatment have been recognized widely. The focus of this article is on the influence of the support layer on the mass transfer in hydrophobic pervaporation. Even though the influence of the support layer on the overall mass transfer has been observed experimentally, the modeling

Binding of charged ligands to macromolecules. Anomalous salt dependence

Although interactions in biological systems occur in the presence of a large number of charged species, the binding of charged ligands to different biomolecules is often analyzed in a simplified model focusing only upon the receptor, ligand, and added salt. Here we demonstrate that the presence of charged macromolecules can affect binding to the receptor in an unexpected way. Experimental studies

Matching Parton Showers and Matrix Elements

We compare different procedures for combining fixed-order tree-level matrix element generators with parton showers. We use the case of W-production at the Tevatron and the LHC to compare different implementations of the so-called CKKW scheme and one based on the so-called MLM scheme using different matrix element generators and different parton cascades. We find that although similar results are o

An Ael allele-specific nucleotide insertion at the blood group ABO locus and its detection using a sequence-specific polymerase chain reaction

Genomic DNA from each of four Acl individuals (genotypes AO1, AO1var, AO2) and one AclB individual was used as a template for amplifying exons 6 and 7 of the ABO genes, which were subsequently sequenced. In all the Ael alleles a single nucleotide insertion, compared to the A consensus sequence, was observed that would alter the amino acid sequence of the glycosyltransferase immediately after its p

ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical actiflty by glucose in wild-type and SUR1(-/-) mouse alpha-cells

Patch-clamp recordings and glucagon release measurements were combined to determine the role of plasma membrane ATP-sensitive K+ channels (K-ATP channels) in the control of glucagon secretion from mouse pancreatic alpha-cells. In wild-type mouse islets, glucose produced a concentration-dependent (half-maximal inhibitory concentration [IC50] = 2.5 mmol/l) reduction of glucagon release. Maximum inhi

Economic Aspects of Ageing

This thesis concerns economic aspects of ageing and investigates incentives and outcomes related to this process. The thesis is a collection of five essays. An introductory chapter provides an overall economic perspective of ageing. Essay 1 (ch 2) examines mortality risks via duration analysis of widowed individuals in Scania, Sweden during the 19th century. The findings are qualitatively in line

Att tala med, mot och förbi varandra : Samtal mellan föräldrar och skolledning på en dövskola

Popular Abstract in Swedish Inom många olika fält hyllas dialogen. Det finns en stark och utbredd tro, främst i det västerländska samhället, att lyckas man bara upprätta en dialog kan man planera i samförstånd och lösa problem. Människor talar med varandra för att förstå, hjälpa varandra och för att skapa gemensamma värden och målsättningar. I studiet av samtal upptäcker man emellertid snabbt att In the spring of 1997 a group of parents of deaf and hearing-impaired children and representatives of a special school in the south of Sweden began to hold formally arranged meetings in order to start a “dialogue”. This particular form of collaboration became the focus of this study. The meetings lasted two to three hours and I attended seventeen of them. The transcriptions of those meetings form

Extending autonomy by substituting judgment: A case of mistaken identity

According to the so-called Substituted Judgment Standard, a surrogate decision maker, acting on behalf of an incompetent patient, ought to make that health care decision which the patient would have made, had the latter been competent. The most common way of justifying the Substituted Judgment Standard is to maintain that this standard extends patients’ opportunities for self-determination to situ