T-Cell Development: Transcriptional and Epigenetic Regulation in BCL11B Activation
Haematopoietic stem cells are the source of all blood components including T-cells. When the T-cell programme is initiated in these cells, the expression of T-cell associated genes such as TCF7 is up-regulated, while genes opposing this fate are turned off. Subsequently, epigenetic marks on the gene BCL11B and its regulatory elements, disabling the expression of the gene, are removed and the trans