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Multi-Dimensional Quantitative Laser-based Diagnostics - Development and Practial Applications

Popular Abstract in Swedish De vanligaste anledningarna till att vi eldar idag är att skapa värme, elektricitet eller mekanisk energi (som till exempel i bilar och andra fordon). När man eldar bildas kemikalier och partiklar som är skadliga för hälsa och miljö. För att minimera mängden av dessa skadliga utsläpp och för att optimera mängden energi som man kan utvinna från en viss mängd bränsle, är Laser based optical diagnostic methods are routinely used in combustion research. Many of the more common approaches are based on illuminating a cross-section of the sample with a thin laser sheet. For example, by targeting an electronic transition in a molecule, its concentration within the plane illuminated by the laser sheet can be deduced. By probing the relative occurrence of an atom or molec

Komplexiteten saknas

Recension av Henrik Arnstad; Skyldig till skuld. En europeisk resa i Nazitysklands skugga.

Calibrating floor field cellular automaton models for pedestrian dynamics by using likelihood function optimization

The formulation of pedestrian floor field cellular automaton models is generally based on hypothetical assumptions to represent reality. This paper proposes a novel methodology to calibrate these models using experimental trajectories. The methodology is based on likelihood function optimization and allows verifying whether the parameters defining a model statistically affect pedestrian navigation

Malignant melanoma-Risk factors and the CDKN2A mutation in relation to phenotypes and other cancers.

Background: Cutaneous malignant melanoma (CMM) is an increasingly common cancer in fair-skinned people. The purpose of this thesis was to study high-risk patients with multiple tumours including a CMM, high-risk families with the unique Swedish germline mutation in CDKN2A(113insArg), as well as study risk factors for CMM in women. Methods: Tumours associated with CMM, in individuals/probands with

Categories by Heart: Shortcut Reasoning in a Cardiology Clinic

This article examines the practice of doctors and nurses to invoke the categories of age, sex, class, ethnicity, and/or lifestyle factors when discussing individual patients and patient groups. In what situations are such references explicitly made, and what does this practice accomplish? The material consists of field notes from a cardiology clinic in Sweden, and a theory of descriptive practice

Cystatin C Deficiency Promotes Epidermal Dysplasia in K14-HPV16 Transgenic Mice

Background: Cysteine protease cathepsins are important in extracellular matrix protein degradation, cell apoptosis, and angiogenesis. Mice lacking cathepsins are protected from tumor progression in several animal models, suggesting that the regulation of cathepsin activities controls the growth of various malignant tumors. Methods and Results: We tested the role of cathepsins using a mouse model o

Incidence of Diabetes Mellitus and Evolution of Glucose Parameters in Growth Hormone-Deficient Subjects During Growth Hormone Replacement Therapy A long-term observational study

OBJECTIVE Growth hormone (GH) deficiency is associated with insulin resistance and diabetes. The aim of the current study was to determine incidence of diabetes during GH replacement therapy (GHRT) and the effect of GHRT on fasting plasma glucose concentrations and HbA(1c) in adult patients with GH deficiency. RESEARCH DESIGN AND METHODS-A total of 5,143 GH-deficient patients (male 49.9%; mean age

Maximum host survival at intermediate parasite infection intensities.

BACKGROUND: Although parasitism has been acknowledged as an important selective force in the evolution of host life histories, studies of fitness effects of parasites in wild populations have yielded mixed results. One reason for this may be that most studies only test for a linear relationship between infection intensity and host fitness. If resistance to parasites is costly, however, fitness may

Aldosterone synergizes with peripheral inflammation to induce brain IL-1β expression and depressive-like effects.

Recent findings have shown that the physiological functions of the hormone aldosterone go far beyond its well-known role in blood-pressure regulation and salt/water homeostasis. Aldosterone is for example involved in the regulation of inflammation, and also binds directly to mineralocorticoid receptors in specific brain regions. Interestingly, depressive symptoms appear to correlate with alteratio

High Current Density InAsSb/GaSb Tunnel Field Effect Transistors

Steep-slope devices, such as tunnel field-effect transistors (TFETs), have recently gained interest due to their potential for low power operation at room temperature. The devices are based on inter-band tunneling which could limit the on-current since the charge carriers must tunnel through a barrier to traverse the device. The InAs/GaSb heterostructure forms a broken type II band alignment wh

Relaxed step functions for evaluation of CCN counter data on size-separated aerosol particles

tmospherically important data are gained from cloud condensation nucleus counter (CCNC) analysis of aerosols that are particle mobility separated using differential mobility analysers (I)MA). We present relaxed step functions that can be fitted to these data to obtain critical diameters or critical supersaturations. The step functions are based on the DMA transfer function. We treat the case with

Measurement of the jet fragmentation function and transverse profile in proton-proton collisions at a center-of-mass energy of 7 TeV with the ATLAS detector

The jet fragmentation function and transverse profile for jets with 25 GeV < p(Tjet) < 500 GeV and |eta(jet)| < 1.2 produced in proton-proton collisions with a center-of-mass energy of 7 TeV are presented. The measurement is performed using data with an integrated luminosity of 36 pb(-1). Jets are reconstructed and their momentum measured using calorimetric information. The momenta of the charged

Pitch, loudness and frequency selectivity in low-frequency hearing loss

Patients with Ménière's disease and cochlear hydrops show fluctuating low-frequency hearing loss (FLFHL). At present these changes are followed as patients' subjective reports and occasional measurements. Consecutive long-term measurements should provide more comprehensive information on the hearing fluctuations than the occasional audiogram used today and constitute an approach to quantify the fl

Increased risk of atrial fibrillation in patients with coeliac disease: a nationwide cohort study

Aims Inflammatory markers are established risk factors for atrial fibrillation (AF), but the role of autoimmune diseases is unknown. The aim of the study was to examine the association between coeliac disease (CD) and AF in a large cohort of patients with biopsy-verified CD. Methods and results We identified 28 637 patients with CD through biopsy reports (defined as Marsh 3: villous atrophy) from

Accuracy and Precision of Radioactivity Quantification in Nuclear Medicine Images

The ability to reliably quantify activity in nuclear medicine has a number of increasingly important applications. Dosimetry for targeted therapy treatment planning or for approval of new imaging agents requires accurate estimation of the activity in organs, tumors, or voxels at several imaging time points. Another important application is the use of quantitative metrics derived from images, such