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Ipragliflozin and sitagliptin differentially affect lipid and apolipoprotein profiles in type 2 diabetes : the SUCRE study

BACKGROUND: SGLT2 inhibitors and DPP4 inhibitors have been suggested to affect lipid metabolism. However, there are few randomized controlled trials comparing the effects on the lipid metabolism between the two types of antidiabetic drugs. The SUCRE study (UMIN ID: 000018084) was designed to compare the effects of ipragliflozin and sitagliptin on serum lipid and apolipoprotein profiles and other c

Evolution of Pleural Solitary Fibrous Tumors Causing Severe Hypoglycemia after Exceptionally Long Asymptomatic Periods : Report of Two Surgical Cases

Non-islet cell tumor hypoglycemia (NICTH) is one of the paraneoplastic syndromes manifesting severe hypoglycemia caused by aberrant production of high-molecular-weight insulin-like growth factor 2 (big-IGF2). Two surgical cases of extremely large thoracic solitary fibrous tumors (SFT) with unusual history of NICTH are presented. One case manifested severe hypoglycemia after four years of the first

Big insulin-like growth factor 2-producing multiple solitary fibrous tumors treated with debulking surgery : A case report

BACKGROUND: Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome caused by a tumor-producing high molecular weight form of insulin-like growth factor 2 (IGF2) known as big IGF2. The only curative treatment for this condition is surgical resection of the responsible tumors. However, this may not be feasible in cases with multiple metastases at diagnosis of NICTH, and no stand

Pussel - Specialistsjuksköterskor inom ambulanssjukvårds erfarenheter av bedömning i prehospital miljö

Bakgrund - Ambulanssjukvården ska kunna bedriva triagering och avancerad sjukvård i det prehospitala rummet. Detta genom rätt kompetens och medicinteknisk utrustning. Riktlinjerna beskrivs som otillräckliga gentemot de patienter som inte bedöms vara kritiska. Ambulanssjuksköterskans bedömningsprocess beskrivs som olika faser som speglar arbetet före, under och efter mötet med patienten. Vårdande bBackground - In today's society, the ambulance services are expected to perform triage and advanced medical care in the prehospital environment. This is achieved through appropriate competence and medical-technical equipment. Guidelines are described as insufficient towards the patients that are not critically ill. The assessment process of the specialist ambulance nurse is described as comple

High-performing phenanthrene-containing poly(arylene piperidinium)s for anion exchange membranes

Incorporating fused benzene rings in backbones of anion conducting polymers may improve the properties of anion exchange membranes (AEMs). Here, we haveprepared and studied ether-free AEMs based on poly(arylene piperidinium)s containing up to 50% phenanthrene units. A series of terpolymers were prepared in superacid-mediated polyhydroxyalkylations of phenanthrene, p-terphenyl and N-methylpiperidon

Analysis of self-monitoring of blood glucose metrics in gestational diabetes mellitus and their association with infants born large for gestational age : A historical observational cohort study of 879 pregnancies

Introduction: Self-monitoring of blood glucose (SMBG) is the standard of care for women with gestational diabetes mellitus (GDM). This study aimed to review SMBG profiles in women with GDM and to examine how glucose metrics derived from SMBG relate to fetal overgrowth and infants born large for gestational age (LGA, >90th percentile). Material and Methods: This was a single-center, historical, obs

Affordances of community-oriented praxis in teacher education : a configurative review

This configurative review explores how nurturing and enacting a community-oriented praxis (COP) in teacher education can enhance teacher candidates’ preparedness for teaching roles whilst addressing some broader educational and societal concerns. Here, CoP is defined as practices that consider, connect with, and draw on local community strengths, needs, and aspirations for the good of individuals,

Against lifetime QALY prioritarianism

Lifetime quality-adjusted life-year (QALY) prioritarianism has recently been defended as a reasonable specification of the prioritarian view that benefits to the worse off should be given priority in health-related priority setting. This paper argues against this view with reference to how it relies on implausible assumptions. By referring to lifetime QALY as the basis for judgments about who is w

Association between endostatin and mortality in patients with acute dyspnoea, with or without congestive heart failure: a single-centre, prospective, observational study

Objective The aim of this study was to assess associations between endostatin levels and short-term mortality in unsorted acute hospitalised dyspnoea patients with or without congestive heart failure (CHF), adjusted for common cardiovascular risk factors.Design, setting and participants In this prospective observational study, 723 hospitalised patients who visited the emergency department at Skåne

Preschool class pupils’ enhanced subitizing abilities by learning study interventions

Purpose: This study explores variation theory-based interventions’ contribution to enhancing preschoolers’ subitizing abilities during iterative lessons. Results are presented according to low, middle and high achievers, focused on those with prominent challenges. Design/methodology/approach: In total 68 Swedish preschoolers participated. They were randomly assigned to one of the intervention/cont

Socialsekreterares upplevelser av standardisering inom ekonomiskt bistånd - en kvalitativ intervjustudie

Standardization of the public sector in Sweden has noticeably increased in the last three decades. The study aims to examine social workers' experiences of standardization in the work with social assistance from two focus points - experiences of professional practice and professional discretion. The method of the study was qualitative semi-structured interviews involving social workers from tw

MYC protein is a high-risk factor in mantle cell lymphoma and identifies cases beyond morphology, proliferation and TP53/p53 – a Nordic Lymphoma Group study

The transcription factor MYC is a well-described oncogene with an important role in lymphomagenesis, but its significance for clinical outcome in mantle cell lymphoma (MCL) remains to be determined. We performed an investigation of the expression of MYC protein in a cohort of 251 MCL patients complemented by analyses of structural aberrations and mRNA, in a sub-cohort of patients. Fourteen percent

När HR granskar CV med AI

Denna studie syftar till att undersöka de sociologiska implikationerna som existerar kring Human Resources (HR) användning av Artificiell Intelligens (AI)-verktyg inom rekryteringsarbete. Studien har ett sociologiskt fokus i form av de teorier som appliceras på analysen av studiens resultat. Dessa teoretiska ramverk är institutionell teori, som används för att förklara hur organisatoriska trender The aim of this essay is to examine the implications that Human Resources (HR) usage of Artificiall Intelligence (AI) in recruiting processes have in relation to a sociological theoretical framework. The aim is to highlight both positive and negative aspects of this and discuss these factors in relation to sociological institutional theory as well as theory of symbolic interactionism. The topic of

Party responsiveness to public opinion in a multi-dimensional policy space

Party responsiveness to public opinion is a key question in the study ofdemocratic representation. While numerous studies have examined partyresponsiveness on broad ideological dimensions, there is less comparativeresearch on when and how parties respond to public opinion on morespecific issue dimensions. We aim to address this research gap by studyingparty positional responsiveness on seven issue

Healthy ageing in long-term care? Lessons learned from the COVID-19 pandemic : A position paper

Aim: This position paper focuses on healthy ageing for the frailest and institutionalized older adults in the context of the recent pandemic. The paper aims to identify and discuss hindering and promoting factors for healthy ageing in this context, taking both health safety and a meaningful social life into account, in a pandemic situation and beyond. Background: The recent COVID-19 pandemic has h

Extragalactic stellar tidal streams in the Dark Energy Survey

Context. Stellar tidal streams are a key tracer of galaxy evolution and have the potential to provide an indirect means for tracing dark matter. For the Local Group, many diffuse substructures have been identified and their link to galaxy evolution has been traced. However, the Local Group does not offer a statistically significant sample of stellar tidal streams. Thus, an analysis of a larger sam