Popular Abstract in Swedish Alzheimers sjukdom (eng. Alzheimer’s disease, AD) är den vanligaste orsaken till de- mens. Demens innebär en permanent sänkning av intellektuella förmågor som påverkar individen påtagligt i vardagen. Förekomsten av demenssjukdomar ökar betydligt efter 65 års ålder. AD är en långsamt progredierande sjukdom, som oftast börjar med försämrat närminne. Redan idag är AD en beBackground: Alzheimer’s disease (AD) is the most common cause of dementia. In order to have effect of future disease-modifying therapies for AD, the disease must be identified early, before the patients have developed dementia. Many patients with Mild Cognitive Impairment (MCI) have prodromal AD, but other causes for the syndrome are common. No diagnostic method can identify AD in patients with MC

The question of who appropriates the economic rents created by resources and capabilities has remained largely unresolved in strategic management. The aim of this paper is to highlight the problem established strategic management theory faces in explaining value appropriation, and to propose a framework that addresses how R&C affect bargaining power and value appropriation. While resource-base

Tasquinimod (a quinoline-3-carboxyamide) is a small molecule immunotherapy with demonstrated effects on the tumor microenvironment (TME) involving immunomodulation, anti-angiogenesis and inhibition of metastasis. A target molecule of tasquinimod is the inflammatory protein S100A9 which has been shown to affect the accumulation and function of suppressive myeloid cell subsets in tumors. Given the m

Immunosenescence, the aging of the immune system, is well documented in humans and laboratory models and is known to increase infection risk, morbidity, and mortality among the old. Immunosenescence patterns have recently been unveiled in various free-living populations, but their consequences in the wild have not been explored. We investigated the consequences of immunosenescence in free-living T

Alpha-synuclein (SNCA) protein aggregation plays a causal role in Parkinson's disease (PD). The SNCA protein modulates neurotransmission via the SNAP receptor (SNARE) complex assembly and presynaptic vesicle trafficking. The striatal presynaptic dopamine deficit is alleviated by treatment with levodopa (l-DOPA), but postsynaptic plastic changes induced by this treatment lead to a development of in

Recension av Bengt Gustafsson; Sanningen om ubåtsfrågan. Ett försök till analys.

The aim of the present study was to investigate the size-selectivity of two different synthetic dialyzing membranes, having widely differing sieving properties, with respect to their handling of polydispersed fluorescein isothiocyanate (FITC)-Ficoll, FITC-dextran and of proteins, i.e. I-125-human serum albumin (RISA) and I-125-myoglobin (Myo). Are Ficoll and dextran, compared to proteins, "hyperpe

The purpose of this phase II randomized trial was to evaluate the effect and safety of interferon-2a (IFN) in combination with extended dosing rituximab in patients with symptomatic, advanced indolent lymphoma responding to a standard single course of rituximab. Totally 123 patients were treated with rituximab 375mg/m2 once weekly for 4 weeks leading to 14 complete response (CR; 11%), 56 partial r

The cliff-edge hypothesis introduces the counterintuitive idea that the trait value associated with the maximum of an asymmetrical fitness function is not necessarily the value that is selected for if the trait shows variability in its phenotypic expression. We develop a model of population dynamics to show that, in such a system, the evolutionary stable strategy depends on both the shape of the f

Today’s traffic is one of the main concerns of urban managers. One of the solutions that have been proposed to reduce traffic is encourage people to use public transport instead of personal vehicles, so the quality of public transport should be increased. One way promoting public transport systems quality is creating urban traveler guidance system. In other hand, public transportation network is l

Objective. To evaluate outcome after radical cystectomy for primary bladder cancer in a large population-based material. Material and methods. Between 1997 and 2002 all patients treated with radical cystectomy within 3 months after diagnosis of primary bladder cancer without distant metastasis were retrieved through the Swedish Bladder Cancer Registry. A follow-up questionnaire was distributed to

In recent reports, cerebral vein and sinus thrombosis has had a better long-term prognosis than previously thought. However, there may be long-term problems that have not attracted enough attention. The aim of this chapter is to examine the literature for studies reporting long-term prognosis and outcome after cerebral vein and sinus thrombosis. The long-term prognosis after cerebral vein and sinu

Three accelerator prototype cryomodules (CMs) for the European XFEL have been produced, assembled and tested at DESY in a wide international collaboration. The heat load budget is a key element in the qualification of these CMs. We describe in this paper the measurements performed in the Cryomodule test bench (CMTB) to evaluate the thermal performances of the three prototype CMs. We present at fir