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Conceptual design studies performed with reduced-order approaches allow feasibility and sizing considerations of air-breathing engines to be configured at an affordable computational cost. The present study is devoted to exploring the design space of a dual-mode ramjet engine operating in scramjet mode by means of reduced-order analysis to assess the effects of propulsive system design configurati
The spatial distribution of muscle fibre activity is of interest in guiding therapy and assessing recovery of motor function following injuries of the peripheral or central nervous system. This paper presents a new method for stable estimation of motor unit territory centres from high-density surface electromyography (HDsEMG). This completely automatic process applies principal component compressi
Metals are significant contributors to water pollution, posing serious threats to human health. This study aims to assess the carcinogenic and non-carcinogenic health risks associated with metals in Isfahan drinking water. Eighty water samples were randomly collected from the city's distribution network between January and March 2020–2021. Inductively coupled plasma Optical Emission Spectrometry w
We present property probes, a mechanism for helping a developer explore partial program analysis results in terms of the source program interactively while the program is edited. A node locator data structure is introduced that maps between source code spans and program representation nodes, and that helps identify probed nodes in a robust way, after modifications to the source code. We have devel
Background: The clinical meaningfulness of the effects of recently approved disease-modifying treatments (DMT) in Alzheimer’s disease is under debate. Available evidence is limited to short-term effects on clinical rating scales which may be difficult to interpret and have limited intrinsic meaning to patients. The main value of DMTs accrues over the long term as they are expected to cause a delay
Purpose: To examine associations of prenatal biomarkers of pesticide exposure with birth size measures and length of gestation among newborns from the Infants' Environmental Health (ISA) birth cohort, Costa Rica. Methods: We included 386 singleton liveborn newborns with data on birth size measures, length of gestation, and maternal urinary biomarkers of chlorpyrifos, synthetic pyrethroids, mancoze
INTRODUCTION: Parkinson's disease (PD) is the second most common neurodegenerative disorder, increasing both in terms of prevalence and incidence. To date, only symptomatic treatment is available, highlighting the need to increase knowledge on disease etiology in order to develop new therapeutic strategies. Hemizygosity for the gene Engrailed-1 ( En1), encoding a conserved transcription factor ess
Fe(II) N-heterocyclic carbene (NHC) complexes have emerged over the last decade as a promising class of light-harvesting complexes for a variety of photochemical applications relying on the presence of high-energy excited states of mainly charge-transfer character with excited state lifetimes of tens of picoseconds or longer. Recent spectroscopic investigations have significantly refined the under
n Charity in Saudi Arabia, Nora Derbal challenges the existing literature on Saudi Arabia’s civil society, giving space and voice to some of its more underappreciated actors. The book includes a mix of personal experiences, ethnographic observation, and detailed descriptions of four civil society organizations (CSOs) and their evolution from 2009 to 2020. In the aftermath of the 2009 flood in Jedd
In this work we computed the phase diagram as a function of temperature and doping for a system of lead adatoms allocated periodically on a silicon (111) surface. This Si(111):Pb material is characterized by a strong and long-ranged Coulomb interaction, a relatively large value of the spin-orbit coupling, and a structural phase transition that occurs at low temperature. In order to describe the co
The combined challenge of climate change and population aging requires novel solutions that enhance the resilience of building energy systems and secure indoor comfort for vulnerable occupants in extreme weather conditions. This research investigates the performance of a newly developed Energy Management (EM) system based on Collective Intelligence (CI) and Reinforcement Learning (RL), called CIRL
Out of hospital cardiac arrest (OHCA) outcomes can be improved by strengthening the chain of survival, namely prompt cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED). However, provision of bystander CPR and AED use remains low due to individual patient factors ranging from lack of education to socioeconomic barriers and due to lack of resources such as limited availab
Though new targeted therapies for colorectal cancer, which progresses from local intestinal tumors to metastatic disease, are being developed, tumor specificity remains an important problem, and side effects a major concern. Here, we show that the protein-fatty acid complex BAMLET (bovine alpha-lactalbumin made lethal to tumor cells) can act as a peroral treatment for colorectal cancer. ApcMin/+ m
The changing nature of the migration phenomenon has influenced the Moroccan context in a different way and has transformed it into a transit and destination country for sub-Saharan migrants. This chapter analyses the evolution of migration trends in Morocco, considering the relation between migration and development in more marginalised areas of the country, such as the Rif region. Moreover, it co
Natural selection generally favours phenotypic variability in camouflaged organisms, whereas aposematic organisms are expected to evolve a more uniform warning coloration. However, no comprehensive analysis of the phenotypic consequences of predator selection in aposematic and cryptic species exists. Using state-of-the-art image analysis, we examine 2800 wing images of 82 moth species accessed via
Aim: The Swedish Renal Registry (SRR) is a unique national quality registry that monitors the clinical trajectory of patients with chronic kidney disease (CKD). We have validated the biopsy data registered in the SRR for IgA Nephropathy (IgAN) diagnosis. Methods: In total 25% of all patients (n = 142), registered with IgAN in the SRR after having performed a kidney biopsy during 2015–2019, were ra
This study investigates the relationship between outdoor life and the well-being and self-esteem of Swedish adolescents aged 12–15 years old (n = 320), residing in three different living environments in the south of Sweden. The study employed a questionnaire that was administered twice during a school year that included questions on time spent outdoors, environmental quality and the perceived bene
Background: Early-stage triple-negative breast cancer (TNBC) displays clinical and biological diversity. From a biological standpoint, immune infiltration plays a crucial role in TNBC prognosis. Currently, there is a lack of genomic tools aiding in treatment decisions for TNBC. This study aims to assess the effectiveness of a B-cell/immunoglobulin signature (IGG) alone, or in combination with tumo
Background: Understanding the relationship among changes in Clinical Dementia Rating (CDR), patient outcomes, and probability of progression is crucial for evaluating the long-term benefits of disease-modifying treatments. We examined associations among changes in Alzheimer’s disease (AD) stages and outcomes that are important to patients and their care partners including activities of daily livin
