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The possibility of directly converting non-neuronal cells into neurons in situ in the brain would open therapeutic avenues aimed at repairing the brain after injury or degenerative disease. We have developed an adeno-associated virus (AAV)-based reporter system that allows selective GFP labeling of reprogrammed neurons. In this system, GFP is turned on only in reprogrammed neurons where it is stab

Understanding the land use history has proven crucial for the conservation of biodiversity in the agricultural landscape. In southern Sweden, very small and fragmented areas of the disturbance-dependent habitat xeric sand calcareous grassland support a large number of threatened and rare plants and animals. In order to find out if historical land use could explain variation in present-day habitat

Fossil soft-shelled turtles (Trionychidae) have so far been recognized in all continents except Antarctica, based largely on remains preserving their diagnostic sculptured shell bones. The origin of the group is generally assumed to be in the Early Cretaceous of Asia, whereas they first appear in North America and Europe during the Late Cretaceous and Paleocene, respectively. Here we describe the

At the time of writing, the Italian Parliament is debating a new law that would make it legal to practice an unproven stem cell treatment in public hospitals. The treatment, offered by a private non-medical organization, may not be safe, lacks a rationale, and violates current national laws and European regulations. This case raises multiple concerns, most prominently the urgent need to protect pa

The effect of a new developed process for biogas boosting was studied at a municipal wastewater treatment plant in industrial scale over the period of three years. After pre-selection studies in the lab and short industrial setups, four hydrolytic enzymes and sodium citrate were combined and tested for a two-year period. The year 2007 was picked as reference year. In February 2008, the dosage was

Coherence in optics and transport is investigated for quantum cascade lasers. While coherence provides oscillations in the gain recovery if the tunnel coupling surpasses the broadening, incoherent hopping transport can fail in the opposite case. (C) 2008 Optical Society of America

The main function of erythropoietin (EPO) is in hematopoiesis where EPO stimulates increased proliferation, survival and differentiation of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different intracellular signaling pathways. Recombinant human EPO (rhEPO) is also used in treatment of cancer patient

A search for a Standard Model Higgs boson decaying via H -> ZZ -> l(+)l(-) nu(nu) over bar, where l represents electrons or muons, is presented. It is based on proton-proton collision data at root s = 7 TeV, collected by the ATLAS experiment at the LHC during 2011 and corresponding to an integrated luminosity of 4.7 fb(-1). The data agree with the expected Standard Model backgrounds. Upper limits

Popular Abstract in Swedish Diabetes är en av de vanligaste folksjukdomarna och tusentals diagnostiseras med sjukdomen varje år. Det finns två typer av diabetes, typ 1 och typ 2. I typ 1 förstörs de insulin producerande β-cellerna som finns i de Langerhanska öarna av kroppens immunförsvar. β-cellerna har till uppgift att reglera blodsockernivåerna. Avsaknaden av egen insulinproduktion leder till dDiabetes affects enormous amounts of patients. In type 1 diabetes the insulin producing β cells in the islet of Langerhans are destroyed by the immune system. The β cells, which are located in the pancreas, regulate blood glucose levels. The lack of insulin production requires administration of insulin. This is accomplished by insulin injections. Even though the treatment methods have been improve

Terahertz spectroscopy is employed for the noncontact measurement of transversal mobility in InP nanowires, wherein photonic effects (waveguiding of excitation beam and propagation of terahertz beam in a complex gradient environment) were successfully deconvoluted. Monte Carlo calculations accounting for electron localization and heavy doping were used to determine electron momentum relaxation tim

AimChildhood obesity is now an established public health problem in most developed countries, and there is concern about a parallel increase of type 2 diabetes. The aim of this study was to estimate the prevalence of undiagnosed type 2 diabetes in overweight Swedish school children from 11 to 13years of age. MethodsBody mass index (BMI) was measured in 5528 schoolchildren in the 6th grade, from 11

The recent phenomenon of large-scale acquisition of land for a variety of investment purposes has raised deep concerns over the food security, livelihood and socio-economic development of communities in many regions of the developing world. This study set out to investigate the food security outcomes of land acquisitions in northern Sierra Leone. Using a mixture of quantitative and qualitative res

In this work, a Study of the interfacial properties of redox-active novel ferrocene- and 1,4-naphthoquinone-based compounds containing an alkenyl chain is presented. The miscibility of these corn. pounds with 1-monooleoylglycerol (monoolein, MO), a well-known and much studied substance because of its rich polyinorphism in water, at the air/water interfaces was investigated by using the Langmuir su

Whereas maintenance of hematopoietic stem cells (HSCs) is a requisite for life, uncontrolled expansion of HSCs might enhance the propensity for leukemic transformation. Accordingly, HSC numbers are tightly regulated. The identification of physical cellular HSC niches has underscored the importance of extrinsic regulators of HSC homeostasis. However, whereas extrinsic positive regulators of HSCs ha

Elater ferrugineus is a saproxylic click beetle inhabiting old deciduous trees in Europe. It is threatened throughout its area of distribution due to habitat loss. No efficient monitoring method has been available for this species, but observed attraction of females to (R)-(+)-γ-decalactone, which is a male-produced sex pheromone of its prey, the scarab beetle Osmoderma eremita, has led to the dev

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded polyglutamine repeat in the huntingtin protein. Neuropathology in the basal ganglia and in the cerebral cortex has been linked to the motor and cognitive symptoms whereas recent work has suggested that the hypothalamus might be involved in the metabolic dysfunction. Several mouse models of HD that display metabol