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Acyl chain disorder and azelaoyl orientation in lipid membranes containing oxidized lipids
Oxidized phospholipids occur naturally in conditions of oxidative stress and have been suggested to play an important role in a number of pathological conditions due to their effects on a lipid membrane acyl chain orientation, ordering, and permeability. Here we investigate the effect of the oxidized phospholipid 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PazePC) on a model membrane of 1-
Standards: Inhospitable Terrain for Innovation
Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients
Rhinovirus infection is a major cause of chronic obstructive pulmonary disease (COPD) exacerbations and may contribute to the development into severe stages of COPD. The macrolide antibiotic azithromycin may exert anti-viral actions and has been reported to reduce exacerbations in COPD. However, little is known about its anti-viral actions on bronchial epithelial cells at clinically relevant conce
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
Intracellular α-synuclein deposits, known as Lewy bodies, have been linked to a range of neurodegenerative disorders, including Parkinson's disease. α-Synuclein binds to synthetic and biological lipids, and this interaction has been shown to play a crucial role for both α-synuclein's native function, including synaptic plasticity, and the initiation of its aggregation. Here, we describe the interp
Tolkning av entreprenadavtal - det köprättsliga kontrollansvaret möter hindersbestämmelserna i AB 04
Högsta domstolens intåg i entreprenadrättens slutna rum
A review of the infection-associated cancers in North African countries
Cancer is typically classified as a leading non-communicable disease; however, infectious agents, such as Helicobacter pylori (H. pylori), hepatitis B virus (HBV), hepatitis C virus (HCV) and human papilloma virus (HPV), contribute significantly to the pathogenesis of various cancers. Less developed countries, including countries of the North African (NA) region, endure the highest burden of infec
Väsentlig rubbning enligt AB 04
Solar control mechanisms for enhanced thermal comfort and daylight control of a fully glazed space
This paper deals with the need of developing a method that can assist designers to select appropriate solarcontrol mechanisms in highly glazed spaces, in order to provide enhanced daylight and views while avoidingoverheating. The development of the method is based on real life needs and was initiated by an actual projectthat we, as building physicists / façade consultants were called in to assist.
Konsten att upprätthålla löneskillnader mellan kvinnor och män : En rättssociologisk studie av regler i lag och avtal om lika lön
Avhandlingen har titeln ”Konsten att upprätthålla löneskillnader mellan kvinnor och män” och är en rättssociologisk studie av vad som stått i vägen för likalöneprincipen, när internationella konventioner och EU-rätten medfört krav på förändringar av kollektivavtal och lagstiftning. Avhandlingens syfte har varit att undersöka och förstå hur löneskillnader mellan kvinnor och män skapas och återskapaThis dissertation, entitled “The Art of Preserving the Gender Pay Gap,” is a study in the sociology of law. It examines the obstructions to the principle of equal pay that persist in the face of international conventions and EU legislation that have mandated changes to legislation and collective bargaining agreements. The dissertation seeks to investigate and explain how the pay gap between women
In memory of Professor Galen S. Wagner M.D., Ph.D. (1939-2016) : Our mentor, colleague and friend
Historical Database of Scanian Agriculture, version 3.0
The Historical Database of Scanian Agriculture (HDSA) is a micro-level database over farm production in the most southern Swedish region of Scania (Skåne) based on flexible tithes. It contains over 85,000 farm level observations of both vegetable and animal production for the period 1702 to 1881. Moreover, this information is supplemented by information on the farmer, the farm, on enclosures, natu
Milk : A postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation
Background: Breastfeeding has protective effects for the development of allergies and atopy. Recent evidence underlines that consumption of unboiled farm milk in early life is a key factor preventing the development of atopic diseases. Farm milk intake has been associated with increased demethylation of FOXP3 and increased numbers of regulatory T cells (Tregs). Thus, the questions arose which comp
Performance of high rate 802.15.4 UWB PHY over multipath fading channels
This paper investigates the performance of high rate IEEE 802.15.4 UWB PHY schemes. Evaluation takes place over office, residential and outdoor IEEE channel models via Monte-Carlo simulation. Special attention is given to the highest rate (27.24 Mbps) scheme that suffers from intersymbol interference (ISI) over NLOS outdoor and residential channels. Optimum bit-to-symbol mapping (OBM), ISI cancell
Activity and Sedentary Time 10 Years After a Successful Lifestyle Intervention : The Diabetes Prevention Program
Introduction: This study aims to determine if evidence exists for a lasting effect of the Diabetes Prevention Program (DPP) lifestyle intervention on activity levels by comparing objectively collected activity data between the DPP Outcome Study (DPPOS) cohort and adults from the National Health and Nutrition Examination Survey (NHANES; 2003-2006). Methods: Average minutes/day of light and moderate
Anticoagulation in patients at high risk of stroke without documented atrial fibrillation. Time for a paradigm shift?
Atrial fibrillation (AF) is currently considered a risk factor for stroke. Depending on the severity of clinical factors (risk scores) a recommendation for full anticoagulation is made. Although AF is most certainly a risk factor for ischemic stroke, it is not necessarily the direct cause of it. The causality of association between AF and ischemic stroke is questioned by the reported lack of tempo
Multi-MHz time-of-flight electronic bandstructure imaging of graphene on Ir(111)
In the quest for detailed spectroscopic insight into the electronic structure at solid surfaces in a large momentum range, we have developed an advanced experimental approach. It combines the 3D detection scheme of a time-of-flight momentum microscope with an optimized filling pattern of the BESSY II storage ring. Here, comprehensive data sets covering the full surface Brillouin zone have been use
The Long-term Durability of Intra-operatively Placed Palmaz Stents for the Treatment of Type Ia Endoleaks After EVAR of Abdominal Aortic Aneurysm
Objective/Background The objective was to analyze the long-term durability of intra-operatively placed Palmaz stents for type Ia endoleaks, and the evolution of aneurysm neck morphology. Methods This was a retrospective cohort study conducted at a tertiary referral centre. Patients treated between 1998 and 2012 were reviewed with regard to pre-, intra-, and post-operative data. Crude and relative
Meniscus morphology : Does tear type matter? A narrative review with focus on relevance for osteoarthritis research
Objective: To give a narrative overview of meniscal tears with a radiologic emphasis on the morphologic type, technical considerations, and on the relevance of the type of meniscal tear in the context of osteoarthritis (OA) research. Design: Total 20 years of the PubMed database were searched for epidemiological, radiological, arthroscopic and biomechanical reports, and review articles focusing on