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Introduction: Current attempts to identify genetic modifiers of BRCA1 and BRCA2 associated risk have focused on a candidate gene approach, based on knowledge of gene functions, or the development of large genome-wide association studies. In this study, we evaluated 24 SNPs tagged to 14 candidate genes derived through a novel approach that analysed gene expression differences to prioritise candidat
During translation, mRNA molecules are incidentally damaged, leaving the ribosome unable to reach or recognize the stop codon and thus stalled with mRNA and a potentially harmful polypeptide product attached to tRNA in the ribosomal P-site. In bacteria, a process called trans-translation has evolved, where a protein-RNA complex (smpB-tmRNA) mimicks the role of aminoacyl charged tRNA in the ribosom
The electrocardiogram (ECG) is the most widely used imaging tool helping in diagnosis and initial management of patients presenting with symptoms compatible with acute coronary syndrome. Acute ischemia affects the configuration of the QRS complexes, the ST segments and the T waves. The ECG should be read along with the clinical assessment of the patient. ST segment elevation (and ST depression in
Folate plays an important role in the synthesis and methylation of DNA as a cofactor in one-carbon metabolism. Inadequate folate intake has been linked to adverse health events. However, comparable information on dietary folate intake across European countries has never been reported. The objective of the present study was to describe the dietary folate intake and its food sources in ten countries
Academic cultures might be perceived as conservative, at least in terms of development of teaching and learning. Through a lens of network theory this conceptual article analyses the pattern of pathways in which culture is constructed through negotiation of meaning. The perspective contributes to an understanding of culture construction and maintenance with a potential to aid academic developers a
The African party literature, especially research prescribing to the long-dominant ethnic voting thesis, has asserted that African party systems exhibit low levels of party nationalization. However, systematic research on nationalization across parties and party systems is still lacking. This study argues that the prospects for building nationalized parties vary substantially between incumbent and
Terroristattackerna i USA den 11 september 2001 fick inga omedelbara och genomgripande konsekvenser för Sveriges säkerhetspolitik. Det av George W. Bush deklarerade kriget mot terrorismen uppfattades inte primärt som ett svenskt säkerhetsproblem eller något som direkt berörde svenska säkerhetsintressen. Sverige betraktade sig fortfarande huvudsakligen som en åskådare, inte som en medagerande och ä
Monte Carlo simulations show that charge-regulation alone can cause highly charged zirconium nanoparticles to adsorb to a similarly charged or neutral silica particle and thereby stabilizing the latter. This mechanism, referred to as halo stabilization, is quite general and applicable in a range of systems provided that pH, van der Waals forces, and dissociation constants of the charge-regulating
Aim: Invasive urothelial carcinoma of the bladder (UCB) is characterized by alterations in cell-cycle regulatory pathways. Defects in the expression of cyclin D1, a key cell-cycle regulator, have been implicated in progression of various types of cancer. In the present study, we investigated whether cyclin D1 expression is associated with clinicopathological parameters and whether it has any poten
The truncated hemoglobin from Bacillus subtilis (trHb-Bs) possesses a surprisingly high affinity for oxygen and resistance to (auto)oxidation; its physiological role in the bacterium is not understood and may be connected with its very special redox and ligand binding reactions. Electron transfer reactions of trHb-Bs were electrochemically studied in solution and at graphite electrodes. Spectropho
This paper presents results from a comparative project on the implementation of elder-care in France and Sweden. The transition to requiring care is understood as a process, and elder-care is seen as a part of a more general organisation of social care that reflects different welfare traditions. An overview of elder-care on the institutional level in the two countries is supplemented by case studi
In this paper we analyze how the spatiality of interactions influences trust creation in multi-site corporate innovation projects. By drawing on insights from the discussion on initial and gradual trust in combination with contributions from the field of economic geography, we examine factors influencing the creation of trust and their dependence on face-to-face interaction. We develop a conceptua
OBJECTIVES: Hairdressers often complain of work-related rhinitis (WR). They are infrequently sensitized to persulphates. The cause and mechanism of the symptoms and the effects on their health-related quality of life (HRQoL) remains unclear. The objectives were to follow female hairdressers with WR mainly from bleaching powder regarding nasal reactivity to persulphate and to evaluate symptoms, HRQ
Intralocus sexual conflict (ISC) occurs when males and females have different adaptive peaks but are constrained fromevolving sexual dimorphism because of shared genes. Implications of this conflict on evolutionary dynamics in wild populations have not been investigated in detail. In comprehensive analyses of selection, heritability, and genetic correlations, we found evidence for an ISC over wing
We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individuals. We then assessed selected single-nucleotide polymorphisms (SNPs) for osteoporotic fracture in 2,
In a recent article, David (Tarski’s convention T and the concept of truth, pp. 133–156, 2008) distinguishes between two interpretations of Tarski’s work on truth. The standard interpretation has it that Tarski gave us a definition of truth in-L within the meta-language; the non-standard interpretation, that Tarski did not give us a definition of true sentence in L, but rather a definition of trut
An efficient integral equation based solver is constructed for the electrostatic problem on domains with cuboidal inclusions. It can be used to compute the polarizability of a dielectric cube in a dielectric background medium at virtually every permittivity ratio for which it exists. For example, polarizabilities accurate to between five and ten digits are obtained (as complex limits) for negative
Patients with acute dyspnea are a large heterogeneous patient group where initial management is important for outcome.
Climate data from Empakaai Crater in northern Tanzania, covering the last 1200 years, are related to the establishment, development and decline of the ancient irrigation system at Engaruka. New dates for the system are linked to reconstructed climatic variations and historical data on long-distance and regional trade and migration patterns. A shift from a comparatively humid climate to drier condi
