Nowadays, we live in a society with billions of devices that are interconnected and interact together to improve the quality of our lives. The management and processing of information and knowledge have by now become our main resources, and the fundamental factors of economic and social development, and it is achieved through Big Data Frameworks (BDFs). The amount of such data is becoming larger e

The problem of identifiability of processes using measurements obtained under closed loop operation is treated. Single input-single output systems are considered. It is assumed that the feedback is time invariant, linear and noise free. It is also assumed that no external input signal is injected. Conditions, which are simultaneously necessary and sufficient for identifiability are derived. The re

Introduction: Previous studies have shown that the injection of adipose tissue–derived stem cells (ADSCs) into the tunica albuginea (TA) during the active phase of Peyronie's disease (PD) prevents the development of fibrosis. Aim: To investigate, using an animal model, whether local injection of human ADSCs (hADSCs) can alter the degree of fibrosis in the chronic phase of PD. Methods: 27 male, 12-

Objective: The effectiveness of golimumab in Crohn’s disease (CD) is largely unknown as it is not approved for the treatment of the disease. We aimed to identify the population of CD patients treated with golimumab in Sweden, to assess the effectiveness of golimumab (defined as the drug retention rate), and to identify predictors of drug discontinuation. Methods: Patients with CD who received at l

We investigate the evolution of relatedness linkages between Swedish industries during five sub-periods between 1991 and 2010. Distinguishing between the stable ties (present in all subperiods) and non-stable ties (emerging, disappearing, etc), we demonstrate that the relatedness linkages change considerably over time. Furthermore, we show that the changes in the relatedness matrix matter for the

Emergence of a classical particle trajectory concept from the full quantum description is a key feature of quantum mechanics. Recent progress of solid-state on-demand sources has brought single-electron manipulation into the quantum regime; however, the quantum-to-classical crossover remains unprobed. Here we describe theoretically a mechanism for generating single-electron wave packets by tunneli

Parkinson's disease (PD) is characterized by proteinaceous aggregates named Lewy Bodies and Lewy Neurites containing α-synuclein fibrils. The underlying aggregation mechanism of this protein is dominated by a secondary process at mildly acidic pH, as in endosomes and other organelles. This effect manifests as a strong acceleration of the aggregation in the presence of seeds and a weak dependence o

Fundamental to regulatory guidelines is to identify chemicals that are implicated with adverse human health effects and inform public health risk assessors about “acceptable ranges” of such environmental exposures (e.g., from consumer products and pesticides). The process is made more difficult when accounting for complex human exposures to multiple environmental chemicals. Herein we propose a new

Given the growing importance of bike-sharing systems nowadays, in this paper we suggest an alternative approach to mitigate the most crucial problem related to them: the imbalance of bicycles between zones owing to one-way trips. In particular, we focus on the emerging free-floating systems, where bikes can be delivered or picked-up almost everywhere in the network and not just at dedicated dockin

A numerical formulation is provided for secondary ice production during fragmentation of freezing raindrops or drizzle. This is obtained by pooling laboratory observations from published studies and considering the physics of collisions. There are two modes of the scheme: fragmentation during spherical drop freezing (mode 1) and during collisions of supercooled raindrops with more massive ice (mod

The Swedish Agency for Health Technology Assessment and Assesment of Social Services (SBU) is an independent national authority, tasked by the government with assessing methods used in health, medical and dental services and social service interventions from a broad perspective, covering medical, economic, ethical and social aspects. The language in SBU's reports are adjusted to a wide audience. S

In this paper we calculate reassigned spectrogramsusing the envelope of an arbitrary signal as matched window. Weshow that the matched window then give the perfectly localizedreassignment for any time-translated and frequency-modulatedtransient signal with corresponding envelope. The general expressions of the corresponding scaled reassignment vectors arederived and the matched window reassignment

Based on various approaches, several different solutions to the smoothing problem have been given. The relationships between these solutions are not immediate, although they solve the same problem. Making use of a certain framework from scattering theory, we derive two families of solutions, with equations evolving forwards and backwards in time, respectively. Within these families three major pre