Introduction: Organophosphates (OPs) are a major public health problem worldwide due to ease of access and high toxicity lacking effective biomarkers and treatment. Cholinergic agents such as OPs and carbamates are responsible for many pesticide-related deaths. While the inhibition of AChE is thought to be the main mechanism of injury, there are other important pathways that contribute to the over

Turbulent drop breakup is of large importance for applications such as food and pharmaceutical processing, as well as of substantial fundamental scientific interest. Emulsification typically takes place in the presence of surface-active emulsifiers (natural occurring and/or added). Under equilibrium conditions, these lower the interfacial tension, enabling deformation and breakup. However, turbule

Bakgrund: Tidigare studier har uppmärksammat bristande följsamhet till riktlinjer i operationssalen som i sin tur ökar risken för vårdrelaterade sårinfektioner. Att hålla nere antalet dörröppningar är en riktlinje där bristande följsamhet uppmärksammats i praktiken. Syfte: Syftet med studien var att observera och registrera trafiken in och ut från operationssalen under pågående sterilt kirurgiskt

In light of video games and gaming becoming a more normalized and widespread phenomenon this essay examines how personal memories are created and used from playing video games. I have used the games BioShock Infinite and Metro 2033 as a basis for this discussion. The study is based on observations of internet forums centred around the games and live streams of people playing them. The theoretical

Production of inclusive charmonia in pp collisions at center-of-mass energy of s = 13 TeV and p–Pb collisions at center-of-mass energy per nucleon pair of sNN = 8.16 TeV is studied as a function of charged-particle pseudorapidity density with ALICE. Ground and excited charmonium states (J/ψ, ψ(2S)) are measured from their dimuon decays in the interval of rapidity in the center-of-mass frame 2.5 <

AKT/PKB is a kinase crucial for pluripotency maintenance in pluripotent stem cells. Multiple post-translational modifications modulate its activity. We have previously demonstrated that AKT1 induces the expression of the pluripotency transcription factor Nanog in a SUMOylation-dependent manner in mouse embryonic stem cells. Here, we studied different cellular contexts and main candidates that coul

The study was undertaken to obtain simultaneous measurements of circulating anterior pituitary hormone levels after the i.v. injection of arginine-vasopressin (AVP). Nine healthy men, mean age 31 years (range 24-41), received single blind with at least one week apart, after resting in the supine position for 30 min, AVP 0.26 microgram/kg body weight i.v. (Pitressin, Parke-Davis) or saline in rando

OBJECTIVE: Hypothyroidism can be complicated by bleeding symptoms such as easy bruising, menorrhagia and sometimes even a severe bleeding tendency with fatal outcome. Usually there is a prolonged bleeding time, or a low plasma concentration of coagulation factor VIII (FVIII) or von Willebrand factor (vWF). The aim of the present study was to investigate the acute haemostatic effect of desmopressin

In order to study the influence of the hypothalamic-pituitary-adrenal axis on the levels of endogenous digitalis-like substances (EDLS) in plasma and urine, eight healthy subjects (25-40 years old) were given dexamethasone 1 mg orally and tetracosactide (an ACTH analog) 0.25 mg i.v., on separate occasions. The circulating levels of EDLS, TSH, PRL and AVP following administration of either test dru

Jaktturism anses ofta spela en viktig roll i hållbar landsbygdsutveckling. Turismenkan skapa arbeten, samt bidra till att traditioner och miljöer bevaras. En kommersiell jakt som riktar sig till lokala såväl som inresande jägare kan innebära att viltet kan användas som resurs på flera och nya sätt. När jakten ramas in och paketeras som turismprodukt, där boende, måltider och guidning ingår, kan ja

Examining the relationship between personality and positive psychology can when using a standard measure of personality produce spurious correlations, due to socially desirable responding (aka the evaluative factor). In this study Big Five measures of personality were related to the five most common measures of positive psychology. Using both an evaluative and an evaluatively neutralised measure o

During recent years, we are moving away from the ‘one exposure, one disease’-approach in occupational settings and towards a more comprehensive approach, taking into account the totality of exposures during a life course by using an exposome approach. Taking an exposome approach however is accompanied by many challenges, one of which, for example, relates to the collection of biological samples. M

Using spatial cues such as shape, orientation, and pattern aids visuospatial working memory because it allows strategies that reduce the load on this cognitive resource. One such strategy, namely taking advantage of patterned spatial distributions, remains understudied to date. This strategy demands keeping track of already-searched locations and excluding them from further search and so correlate

Foaming of most bio-based polymers is challenged by low pore formation and foam stability. At the same time, the developing utilization of bio-based materials for the circular economy is placing new demands for easily processable, low-density materials from renewable raw materials. In this work, we investigate cellulose nanofiber (CNF) foams in which foaming is facilitated with wood-based hemicell

The barrier function of the skin is mainly assured by its outermost layer, stratum corneum (SC). One key aspect in predicting dermal drug delivery and in safety assessment of skin exposure to chemicals is the need to determine the amount of chemical that is taken up into the SC. We here present a strategy that allows for direct measures of the amount of various solid chemicals that can be dissolve

The effects of deformed shell structure on the potential energies of the doubly even fp shell nuclei are determined by the macroscopic-microscopic method. The calculated potentials are incorporated in the Bohr Hamiltonian for collective quadrupole motion, and the resulting excitation spectra are compared with experimental data.

The polyaneuploid cancer cell (PACC) state promotes cancer lethality by contributing to survival in extreme conditions and metastasis. Recent experimental evidence suggests that post-therapy PACC-derived recurrent populations display cross-resistance to classes of therapies with independent mechanisms of action. We hypothesize that this can occur through PACC memory, whereby cancer cells that have