Search results

Filter

Filetype

Your search for "*" yielded 528606 hits

Gene expression studies of pregastrulation development: the basement membrane is essential for cell differentiation

Basement membranes (BMs) are sheet-like structures of extracellular matrix. They act as a supporting structure but can also significantly influence cellular behavior in development, tissue homeostasis and disease. Laminins, a major BM component, are multidomain proteins, consisting of three polypeptide chains (α, β and γ). During pregastrulation development, stem cells convert and epithelial tissu

Associations between proteins and heavy metals in urine at low environmental exposures: Evidence of reverse causality

Heavy metals can cause renal effects on vulnerable populations but it is uncertain whether these metals still pose health risks at the low exposure levels now prevailing in most industrialized countries. In a cross-sectional study performed on 736 adolescents, we assessed the associations between the concentrations of cadmium and lead in blood and urine and the urinary concentrations of albumin an

Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients.

Sera from 25 metastatic breast cancer patients and 25 healthy controls were subjected to affinity chromatography using immobilized galectin-1. Serum from the healthy subjects contained on average 1.2 mg per ml (range 0.7-2.2) galectin-1 binding glycoproteins, whereas serum from the breast cancer patients contained on average 2.2 mg/ml (range 0.8-3.9), with a higher average for large primary tumour

Storfjärilar som ökar sin utbredning: nytillskotten i storfjärilsfaunan i sydligaste Sverige under perioden 1973-2009

This study highlights the expansion of butterflies and macromoths occurring in southern Sweden. Recent changes in climate and habitat has been stressed as the main factors influencing changes in species distributions. Climate change implies an increase in temperature and some species are assumed to extend their northern ranges. In this study we compiled information about the first observations of

Att lära, att göra, att klara: Förmedling av datortekniska hjälpmedel till barn medsynnedsättning. Från förskrivning till vardaglig användning iskola och hem

Förmåga att använda informations- och kommunikationsteknik framhålls numera ofta som en förutsättning för delaktighet på lika villkor i samhällslivet. Nära förknippat med detta är de insatser som görs för att överbrygga digitala klyftor i samhället. IKT har gjort deltagandet i samhällslivet mer möjligt för personer med synnedsättning. Tillgång till teknik innebär dock inte alltid att den kan använ

Carbon routes from decomposing plant residues and living roots into soil food webs assessed with C-13 labelling

This field experiment investigated how C from fresh organic amendments and from a growing leek crop was allocated into different soil microbial and faunal groups in an arable field. A C-13-enriched red clover green manure was incorporated in one treatment, while the growing leek crop was pulse labelled with (CO2)-C-13 in another. Incorporation of C-13 into microbial fatty acids, micro- and macroar

The UTCI-Clothing Model

The Universal Thermal Climate Index (UTCI) was conceived as a thermal index covering the whole climate range from heat to cold. This would be impossible without considering clothing as the interface between the person (here, the physiological model of thermoregulation) and the environment. It was decided to develop a clothing model for this application in which the following three factors were con

Pre- and postoperative vomiting in children undergoing video-assisted gastrostomy tube placement.

Background. The aim of this study was to determine the incidence of pre- and postoperative vomiting in children undergoing a Video-Assisted Gastrostomy (VAG) operation. Patients and Methods. 180 children underwent a VAG operation and were subdivided into groups based on their underlying diagnosis. An anamnesis with respect to vomiting was taken from each of the children's parents before the operat

Possibilities of Using Fetal Hemoglobin as a Platform for Producing Hemoglobin-Based Oxygen Carriers (HBOCs).

The expression levels of fetal hemoglobin (HbF) in bacterial recombinant systems are higher compared with normal adult hemoglobin (HbA). However, heme disorientation in globins are often observed in recombinant production processes, both for HbA and HbF, although the degree of heme oriental disorder is much lower for HbF. In addition, the heme disorientation can be converted to a normal conformati

Dissociation between Skeletal Muscle Inhibitor-{kappa}B Kinase/Nuclear Factor-{kappa}B Pathway Activity and Insulin Sensitivity in Nondiabetic Twins.

Context: Several studies suggest a link between increased activity of the inflammatory inhibitor-kappaB kinase/nuclear factor-kappaB (IKK/NF-kappaB) pathway in skeletal muscle and insulin resistance. Objective: We aimed to study the regulation of skeletal muscle IKK/NF-kappaB pathway activity as well as the association with glucose metabolism and skeletal muscle insulin signaling. Methods: The stu

Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells.

Epidemiological studies have shown direct associations between type 2 diabetes and obesity, both conditions associated with hyperglycaemia and hyperinsulinemia, and the risk of pancreatic cancer. Up to 80% of pancreatic cancer patients present with either new-onset type 2 diabetes or impaired glucose tolerance at the time of diagnosis. Recent population studies indicate that the incidence of pancr

Bead-Based Multiplex Genotyping of 58 Cutaneous Human Papillomavirus Types

Cutaneous human papillomaviruses (HPVs) are a heterogeneous, nonmonophyletic assembly, comprising about 50 characterized types and at least 133 isolates putatively representing new types. Their natural history of infection and potential association with nonmelanoma skin cancer are not well understood. Several PCR systems have been developed that amplify a broad spectrum of cutaneous HPVs. However,

Eating disorders and eating pathology in young adult and adult patients with ESSENCE

Background: Little is known about the prevalence and incidence of traditional eating disorders (EDs, e.g., anorexia nervosa (AN), bulimia nervosa and binge eating disorder (BED)) in individuals with childhood onset neuropsychiatric disorders, including attention-deficit/ hyperactivity disorder (ADHD) and autism spectrum disorders (ASD). The aim of the present study was to examine the prevalence of

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1, as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis-regulatory sequences. These associations were dynamic during developmental progression. Occupancy by the

Characteristic mode based tradeoff analysis of antenna-chassis interactions for multiple antenna terminals

The design of multiple antennas in compact mobile terminals is a significant challenge, due to both practical and fundamental design tradeoffs. In this paper, fundamental antenna design tradeoffs of multiple antenna terminals are presented in the framework of characteristic mode analysis. In particular, interactions between the antenna elements and the characteristic modes and their impact on desi