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Kriget och grekerna
Det ord som finns på grekiska för krig, polemos, har i senare europeiska språk avsatt polemik. Svenskans krig, tyskans Krieg, engelskans war, franskans guerre, italienskans guerra – inget av dessa ord stammar från polemos. Det är ett intressant faktum. Hur ska vi tolka det? Är det moderna europeiska kriget ett fenomen som till skillnad från så mycket annat inte går att härleda från grekerna? Och om
Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia : results from the Swedish Family-Cancer Database
The importance of genetic factors in etiology of chronic lymphocytic leukemia (CLL) is suggested by family and population studies. However, the spectrum of malignancies sharing common genetic factors with CLL and the effects of sex and age on familial risk are unknown. We used the Swedish Family-Cancer Database to test for increased familial risks of CLL and other lymphoproliferative tumors. Cance
Familial risks of cancer as a guide to gene identification and mode of inheritance
Occurrence of cancer in parents and offspring may be due to dominant causes, whereas cancer affecting only siblings may indicate a recessive causation. Systematic comparisons of mode of inheritance have not been available for most types of cancer. Using the Swedish Family-Cancer Database, standardized incidence ratios (SIR) were calculated for offspring whose parents or siblings were diagnosed wit
Active Powers and Passive Powers - Do Causal Interactions Require Both?
Many powers metaphysicians postulate both active and passive powers, understood as distinct kinds of intrinsic causal properties of objects. I argue that the category of passive power is superfluous. I also offer a diagnosis of how philosophers are misled to postulate passive powers.Many powers metaphysicians postulate both active and passive powers, understood as distinct kinds of intrinsic causal properties of objects. I argue that the category of passive power is superfluous. I also offer a diagnosis of how philosophers are misled to postulate passive powers.
Molecular phylogeny and higher systematics of the metalmark butterflies (Lepidoptera: Riodinidae)
Riodinidae is a highly diverse buttery family with the majority of its genera restricted to the Neotropics and, despite previous efforts, its higher systematics remains unresolved. Here, we propose a novel phylogenetic hypothesis, based on a comprehensive sample of riodinids, primarily from the Neotropics, covering 67% of all genera and all of the major lineages. We sequenced nine molecular marke
Beyond Access : Characteristics of the Food Environment and Risk of Diabetes
Characteristics of the built environment, including access to unhealthy food outlets, are hypothesized to contribute to type 2 diabetes mellitus (T2D). Swedish nationwide registry data on 4,718,583 adults aged 35-80 years living in 9,353 neighborhoods, each with at least 1 food outlet, were geocoded and linked to commercial registers (e.g., restaurants and grocery stores). Multilevel logistic regr
The population impact of familial cancer, a major cause of cancer
The population attributable fraction (PAF) defines the proportion of a disease that would be prevented if the exposure to a particular risk factor was avoided. Familial risk is a known risk factor for many cancers, but an unbiased estimation of the PAF for familial risk requires a large study population to include rare cancers. PAFs and their corresponding standardized incidence ratios (SIRs) were
Age-specific familial risks of anxiety. A nation-wide epidemiological study from Sweden
OBJECTIVE: Familial risks of anxiety have been assessed in small case-control studies, usually based on reported, but not medically verified, anxiety in family members; thus the degree of familial clustering of these diseases remains to be established.METHODS: The Multigeneration Register, in which all men (sons) and women (daughters) born in Sweden from 1932 onward are registered together with th
Platandivertimento II
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Familial risk for lung cancer by histology and age of onset : evidence for recessive inheritance
The authors used the Swedish Family-Cancer Database to search for evidence for a genetic predisposition in lung cancer. Familial risks in offspring were increased for all lung cancer to 1.77 when a parent was affected with any lung cancers; the comparable risk among siblings was 2.15. At young age, risks between siblings were higher than those between offspring and parents for all histological typ
Tuning the protein phosphorylation by receptor type protein tyrosine phosphatase epsilon (PTPRE) in normal and cancer cells
Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely related with receptor type protein tyrosine phosphatase alpha (PTPRA). PTPRE has b
Global trends in length of stay : implications for destination management and climate change
Length-of-stay (LOS) is a key parameter in destination management that determines the number of guest nights relative to arrival numbers, with concomitant repercussions for revenue generation and other performance indicators. This article investigates the development of LOS for 32 destinations in developed and emerging economies as well as Small Islands and Developing States (SIDS). The analysis i
Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden
AIMS: In the era of genome-wide association studies, familial risks are used to estimate disease heritability and success in gene identification. We wanted to estimate associations of 42 autoimmune diseases with attention-deficit hyperactivity disorder (ADHD) between individuals and family members.PARTICIPANTS AND METHODS: The availability of a Multigeneration Register in Sweden provides reliable
Atrial fibrillation in immigrants under the age of 45 y in Sweden
Aim: To study association between country of birth and risk of first-onset atrial fibrillation (AF) in first- and second-generation immigrants to Sweden under 45 y of age.Methods: The study population included all individuals (n = 3 248 457) under the age of 45 y in Sweden, including immigrants (n = 722 249). AF was defined as first registered diagnosis in the National Patient Register. Associatio
Socioeconomic and occupational risk factors for rheumatoid arthritis : a nationwide study based on hospitalizations in Sweden
OBJECTIVE: To investigate possible associations between socioeconomic status, occupation, and hospitalization for rheumatoid arthritis (RA).METHODS: A nationwide database was constructed by linking the Swedish Census to the Hospital Discharge Register in order to obtain data on all first hospitalizations for RA in Sweden during the study period 1964 to 2004. Standardized incidence ratios (SIR) and
Cancer risk in hospitalized rheumatoid arthritis patients
OBJECTIVES: Patients diagnosed with RA have been at an increased risk of many cancers and at a decreased risk of some cancers. We planned to revisit the theme by using a nation-wide population of RA patients.METHODS: An RA research database was constructed by identifying hospitalized RA patients from the Hospital Discharge Register and cancer patients from the Cancer Registry. Earlier studies from
Level of education and the risk of cancer in Sweden
It is well known that certain cancers have shown clusteringin educational and socioeconomic groups, but recent comprehensive data on clustering by education are limited. We determined standardized incidence ratios (SIRs), adjusted for several variables, for cancer among men and women in six educational groups based on the Swedish Family-Cancer Database. People were identified with a certain educat
Familial risk of urological cancers : data for clinical counseling
Familial risks for cancer are important for clinical counseling and understanding cancer etiology. The nationwide Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0 to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Urological cancer cases were retrieved from the Swedish Cancer Registry up to year 2000. Standardized incidence ratios (SIR