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ICT och BIM i japanska byggindustrin

Den japanska byggsektorn är ofta ett föredöme för vår egen industris omvandling, t.ex. inom industrialisering och lean. Även när det gäller tillämpning och utveckling av Informations- och Kommunikations- Teknologi, ICT, t.ex. för BIM, ByggnadsInformationsModellering, har man mångårig avancerad erfarenhet som är intressant för oss att ta del av. Samtidig visar det sig att användningen och erfarenhe

Multiple exciton generation in nano-crystals revisited: Consistent calculation of the yield based on pump-probe spectroscopy.

Multiple exciton generation (MEG) is a process in which more than one exciton is generated upon the absorption of a high energy photon, typically higher than two times the band gap, in semiconductor nanocrystals. It can be observed experimentally using time resolved spectroscopy such as the transient absorption measurements. Quantification of the MEG yield is usually done by assuming that the bi-e

Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress.

Developmental pluripotency-associated 5 (Dppa5) is an RNA binding protein highly expressed in undifferentiated pluripotent stem cells. Here, we demonstrate that Dppa5 is a regulator of hematopoietic stem cells (HSCs) that critically governs reconstitution capacity after bone marrow transplantation. Ectopic expression of Dppa5 followed by in vitro culture robustly increased HSC reconstitution level

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by production of autoantibodies and complex genetic inheritance(1-3). In a genome-wide scan using 85,042 SNPs, we identified an association between SLE and a nonsynonymous substitution (rs10516487, R61H) in the B-cell scaffold protein with ankyrin repeats gene, BANK1. We replicated the association in four indepen

A MATTER OF NUTRIENT EXCESS AND SHEAR STRESS

The metabolic syndrome is a clustering of several risk factors associated with diabetes and cardiovascular disease. Diabetes is a global problem with 90% of patients suffering from type 2 diabetes (T2D), which is attributable to various factors including genetic predispositions and lifestyle. In T2D, there is a reduction in β cell mass and function, and impaired glucose homeostasis. It is often as

Caught in the Gendered Machine – on the Masculine and Feminine in Cyborg Leadership

Many studies have shown that female managers have to work harder than men to gain recognition, and that this often leads top female managers away from the leadership style characterized by soft skills and emotional understanding. Instead, another characterization can be seen; that of tough gendered machines fighting their way to the top - cyborgs. This article uses Haraway's metaphor of the cyborg

Psychiatric and metabolic disturbances in experimental models of Huntington’s disease

Popular Abstract in Swedish Huntingtons sjukdom (HS) är en ärftlig och dödlig sjukdom som karakteriseras av ofrivilliga, danslika rörelser vilket gjort att den i folkmun kallas för danssjuka. Diagnosen ställs när de motoriska problemen (ofrivilliga rörelserna) uppträder, vanligtvis i medelåldern, och dessa ökar sedan gradvis och den drabbade personen avlider på grund av sjukdomen efter cirka 15-25Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington’s disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features. The hypothalamus has emerged as an

Enhancing bone healing through concurrent anabolic- and anti-catabolic pharmacological treatment

Most fractures heal uneventfully but some evolve into nonunions. Autologous bone graft is the gold standard for stimulating healing. However, donor site morbidity, and limited graft supply make alternatives interesting. Bone Morphogenetic Proteins, BMPs, are growth factors involved in bone signaling. They are available in recombinant form for local application in nonunions and stimulate differenti

Effect of cereal test breakfasts differing in glycemic index and content of indigestible carbohydrates on daylong glucose tolerance in healthy subjects

BACKGROUND: Frequent hyperglycemic episodes are increasingly being associated with an increased risk of type 2 diabetes and cardiovascular disease. OBJECTIVE: We studied the extent to which acute glycemia and glycemia after subsequent meals can be modulated by the characteristics of cereal foods, such as glycemic index (GI) and content of indigestible carbohydrates. DESIGN: Twelve healthy subjects

Synthesis and single crystal study of CuMn3As2 and Cu2Mn4As3

We report on single-crystal growth, and crystal structure of CuMn3As2 and Cu2Mn4As3 compounds. Magnetic properties of Cu2Mn4As3 were studied in temperature range between 2 and 400 K. The single crystals were prepared from bismuth flux and characterized by means of single crystals diffraction, electron-microprobe analysis, magnetic and resistivity measurements. Crystal structures of CuMn3As2 and Cu

Children with Type 1 diabetes The initial education process and the impact on children and their parents over the first two years

The overall aim of this thesis was to investigate the initial diabetes education process, the impact on children and their parents and parental satisfaction with the care received one and two years subsequent to the child’s diagnosis. In order to seek a deeper understanding for how the diabetes team’s initial education process works from admission to discharge among families with a child newly dia

One-dimensional spin texture of Bi(441): Quantum spin Hall properties without a topological insulator

The high index (441) surface of bismuth has been studied using scanning tunneling microscopy (STM), angle resolved photoemission spectroscopy (APRES), and spin-resolved ARPES. The surface is strongly corrugated, exposing a regular array of (110)-like terraces. Two surface localized states are observed, both of which are linearly dispersing in one in-plane direction (k(x)), and dispersionless in th

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Rapporten som er opdelt i fire delrapporter er udarbejdet i projektet ”ICT i byggesektoren – Netværk til udvikling”, som er delfinansieret af regionsudviklingsprojektet Interreg IIIA. ”ICT i byggesektoren – netværk til udvikling”. Projektet styrer mod, via et netværk om IKT omkring Øresund, at muliggøre bedre, billigere og mere miljørigtigt byggeri og boliger, ved at identificere og fjerne hindrin

Evaluation of the Evidence for the Trauma and Fantasy Models of Dissociation

The relationship between a reported history of trauma and dissociative symptoms has been explained in 2 conflicting ways. Pathological dissociation has been conceptualized as a response to antecedent traumatic stress and/or severe psychological adversity. Others have proposed that dissociation makes individuals prone to fantasy, thereby engendering confabulated memories of trauma. We examine data

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This thesis, “Die Wiedergabe der Wirklichkeit” (“The Reported Reality”), explores from a contrastive perspective what linguistic strategies serious German and Swedish newspapers use in different text genres as they report from reality. Two German – die Frankfurter Allgemeine Zeitung and die Süddeutsche Zeitung – and two Swedish newspapers – Dagens Nyheter and Svenska Dagbladet – are studied. For e

Functional response to cholinesterase inhibitor therapy in a naturalistic Alzheimer's disease cohort

Background: Activities of daily living (ADL) are an essential part of the diagnostic criteria for Alzheimer's disease (AD). A decline in ADL affects independent living and has a strong negative impact on caregiver burden. Functional response to cholinesterase inhibitor (ChEI) treatment and factors that might influence this response in naturalistic AD patients need investigating. The aim of this st

Multi Level Environmental Governance – The Case of Wind Power Development in Sweden

At national policy level in Sweden, the importance of development of wind power is emphasized. However, the actual implementation is highly dependent on local permit giving for windmills. The legislation governing the permit giving has been revised in an attempt to make the local processes faster and to shift the permit process towards a more regional environmental process as opposed to a more pla

Sensing Mechanism for Biothiols Chemosensor DCO: Roles of Excited-State Hydrogen-Bonding and Intramolecular Charge Transfer

The biothiols sensing mechanism of (E)-7-(diethylamino)-3-(2-nitrovinyl)-2H-chromen-2-one (DCO) has been investigated using the density functional theory (DFT) and time-dependent DFT methods. The theoretical results indicate that the excited-state intermolecular hydrogen bonding (H-B) plays an important role for the biothiols sensing mechanism of the fluorescence sensor DCO. Multiple H-B interacti