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Substrate-binding model of the chlorophyll biosynthetic magnesium chelatase BchH subunit.

Photosynthetic organisms require chlorophyll and bacteriochlorophyll to harness light energy and transform water and carbon dioxide into carbohydrates and oxygen. The biosynthesis of these pigments is initiated by magnesium chelatase, an enzyme composed of BchI, BchD and BchH proteins, which catalyzes the insertion of Mg(2+) into protoporphyrin IX (Proto) to produce Mg-protoporphyrin IX. BchI and

Aneurysm expansion and retroperitoneal hematoma after thrombolysis for stent-graft limb occlusion caused by distal endograft migration

PURPOSE: To describe a complication of thrombolytic therapy used to treat graft limb occlusion precipitated by distal migration and kinking of an abdominal aortic stent-graft. CASE REPORT: A 5.5-cm abdominal aortic aneurysm (AAA) in a 66-year-old woman was treated with Vanguard bifurcated stent-graft. At the 1-year follow-up, she complained of left leg claudication. Computed tomography (CT) showed

DNA analysis as a predictor of the outcome of induction chemotherapy in advanced head and neck carcinomas

We investigated whether flow cytometric DNA index and/or ploidy status are predictors of response to chemotherapy and survival. Fifty consecutive patients with previously untreated locally advanced squamous cell carcinomas of the head and neck received induction chemotherapy consisting of three courses of cisplatin (100 mg/m2) and a subsequent 120-hour infusion of fluorouracil (1000 mg/m2 per 24 h

Critical configurations for projective reconstruction from multiple views

This paper investigates a classical problem in computer vision: Given corresponding points in multiple images, when is there a unique projective reconstruction of the 3D geometry of the scene points and the camera positions? A set of points and cameras is said to be critical when there is more than one way of realizing the resulting image points. For two views, it has been known for almost a centu

Systemic lupus international collaborating clinics renal activity/response exercise - Development of a renal activity score and renal response index

Objective. To develop a measure of renal activity in systemic lupus erythematosus and use it to develop a renal response index. Methods. Abstracted data from the medical records of 215 patients with lupus nephritis were sent to 8 nephrologists and 29 rheumatologists for rating. Seven nephrologists and 22 rheumatologists completed the ratings. Each physician rated each patient visit with respect to

Depletion Interactions in Model Microemulsions

The effects of temperature changes and polymer addition on the behavior of droplet microemulsions of nonionic surfactant, water, and decane are reported and analyzed within polymer depletion theory. Dilution viscometry and dynamic light scattering were used to confirm that these microemulsions behave essentially as hard-sphere dispersions, providing us with an ideal reference system. Addition of p

Climate change and Arctic ecosystems: 1. Vegetation changes north of 55 degrees N between the last glacial maximum, mid-Holocene, and present

[1] A unified scheme to assign pollen samples to vegetation types was used to reconstruct vegetation patterns north of 55degreesN at the last glacial maximum (LGM) and mid-Holocene (6000 years B. P.). The pollen data set assembled for this purpose represents a comprehensive compilation based on the work of many projects and research groups. Five tundra types (cushion forb tundra, graminoid and for

Species diversity of campylobacteria in a wild bird community in Sweden

To analyse the occurrence and host species distribution of campylobacteria species in shorebirds, geese and cattle on grazed coastal meadows in Sweden. Species identification was performed through a polyphasic approach, incorporating Amplified Fragment Length Polymorphism (AFLP) profiling, 16S RNA gene sequence analysis together with extensive phenotypic characterization. From 247 sampled birds a

Epidermal growth factor induces cell proliferation in mouse pancreas and salivary glands

Epidermal growth factor (EGF) is a mitogenic stimulus in many tissues and occurs in large amounts in the pancreas and salivary glands. Whether EGF is mitogenic in the pancreas is controversial, and the EGF effect has not been studied in the salivary glands. Therefore, the aim of the present study was to investigate the possible effects on the pancreas and parotid and submandibular glands at differ

Transdermal delivery from a lipid sponge phase-iontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester

The hydrochloride salts of 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA), respectively, were dissolved in a lipid sponge phase comprising monoolein, propylene glycol and aqueous buffer at concentrations of approximately 0.25% and 16% w/w m-ALA. The iontophoretic and passive delivery of ALA and m-ALA from this formulation through porcine skin in vitro were measured and compared to formul

Neonatal frequency discrimination in 250-4000-Hz range: Electrophysiological evidence

Objective: The precision of sound frequency discrimination in newborn infants in the 250-4000-Hz frequency range was determined using the neonatal electrophysiological mismatch response (MMR), the infant equivalent of adult mismatch negativity (MMN). Methods: The electroencephalogram (EEG) was recorded in I 1 full-term sleeping newborn infants mostly in active sleep (67 % of the time). Pure tones

Stability of IQ measures in teenagers and young adults with developmental dyslexia

A follow-up study was performed to investigate the stability of IQ measures in a group of dyslexic teenagers and young adults. Earlier research had shown contradictory results. The 65 subjects, 12 years old on the average at first test, were retested after a mean interval of six and a half years. There was a significant relative decrease in verbal IQ (VIQ), which was interpreted as either an effec

A numerical study of methods to predict the capacity of multiple steel-timber dowel joints

In this study, two numerical methods are used to predict the load-bearing capacity of multiple steel-timber dowel joints loaded parallel to the grain. The aim was to show the possibility and the advantages of using numerical methods when designing multiple dowel-type joints.The results showed a good correlation to experimental results taken from the literature and to traditional joint calculations

First documentation of the Ordovician Guttenberg delta C-13 excursion (GICE) in Asia: chemostratigraphy of the Pagoda and Yanwashan formations in southeastern China

The only published VC data from the Ordovician of China are from the Lower and Upper Ordovician, and only the latter records include a significant excursion, namely the Hirnantian excursion (HICE). Our recent chemostratigraphic work on the Upper Ordovician (Sandbian-Katian) Pagoda and Yanwashan formations at several localities oil the Yangtze Platform and Chiangnan (Jiangnan) slope belt has result

Calculations of nuclear masses at finite angular momenta

The macroscopic-microscopic method to calculate nuclear masses is extended into the high-spin regime in order to calculate the nuclear binding energy as a function of proton number, neutron number and angular momentum. We describe the method and exemplify it on recent experimental data.

Saccharomyces cerevisiae RAP1 bind to telomeric sequences with spatial flexibility

A wide divergence has been detected in the telomeric sequences among budding yeast species. Despite their length and homogeneity differences, all these yeast telomeric sequences show a conserved core which closely matches the consensus RAP1-binding sequence. We demonstrate that the RAP1 protein binds this sequence core, without involving the diverged sequences outside the core. in Saccharomyces ca