Changes in bone matrix composition are frequently found with bone diseases and may be associated with increased fracture risk. Bone is rich in the trace element zinc. Zinc was established to play a significant role in the growth, development, and maintenance of healthy bones; however, the mechanisms underlying zinc effects on the integrity of the skeleton are poorly understood. Here, we show that

The reflectivity spectrum in Vertical-cavity surface-emitting lasers (VCSELs) is investigated by replacing High Contrast Grating (HCG) layer instead of distributed Bragg reflectors (DBR) as a top mirror. In addition, the scalability feature in the HCG layer is used to design a reflector for λ = 1;300 nm. High reflectivity (>99%) mirrors in VCSELs are mandatory because of the short gain length. In

The research in this thesis investigates how atoms and molecules constituting aqueous salt solutions interact using computational approaches, namely Monte Carlo simulations and molecular dynamics simulations. In the first paper, an atomistic model was developed for aqueous solutions of sodium thiocyanate and potassium thiocyanate (NaSCN and KSCN). The model reproduced several experimentally measur

In recent works on the Enlightenment and the origin of modern Western thought, there is often a dichotomy between Moderate versus Radical Enlightenment. This essay evaluates the early experiences of freedom of print in Sweden and Denmark against the backdrop of such assertions. Sweden and Denmark were widely diverging polities but they obtained officially recognized freedom of the press at almost

The pro-apoptotic Bax isoform Bax∆2 was originally discovered in cancer patients with a microsatellite guanine deletion (G8 to G7). This deletion leads to an early stop codon; however, when combined with the alternative splicing of exon 2, the reading frame is restored allowing production of a full-length protein (Bax∆2). Unlike the parental Baxα, Bax∆2 triggers apoptosis through a non-mitochondri

Purpose: The study seeks to shed light on the generative principles of enterprising by examining the practices of enterprisers in six lifestyle enterprises in Sweden. It presents a fresh approach to the study of lifestyle enterprises, resolving a nuanced treatment of the concepts of capital and habitus as often drawn upon in studies using the social theory of Pierre Bourdieu. Design/methodology/ap

Loss of the pro-apoptotic Bcl-2 family protein Bax occurs in ~50% of hereditary nonpolyposis colorectal cancer (HNPCC) due to microsatellite instability (MSI). Recently, we found that some of the "Bax-negative" MSI tumor cells contain a functional Bax isoform, BaxΔ2, which sensitizes cells to selective chemotherapeutics. Here we show the detection of Bax microsatellite mutations and expression of

Purpose – The purpose of this study is to clarify the relation between sustainability practices and financial and market performance, and also, the role of non-financial performance outputs in this relation. Corporate sustainability is a growing area of importance for organizational development. Managing sustainability practices successfully is an imperative in achieving competitive advantage. Des

In 2017, the new SMOS-IC retrieval product of soil moisture (SM) and L-band Vegetation Optical depth (L-VOD) was developed. This product relies on a two-parameter inversion of the L-MEB model (L-band Microwave Emission of the Biosphere) which requires little ancillary information and was found to be accurate, making it very well-suited for application in agriculture, hydrology, climate and vegetat

I december 1919 utkom John Maynard Keynes med sin varning för konsekven- serna av Versaillesfreden, The Economic Consequences of the Peace. Boken gjorde honom i ett slag världsberömd. Den översattes snabbt till svenska och kommenterades av ledande svenska nationalekonomer som David Davidson, Gustav Cassel och Eli Heckscher. De ställde sig alla helhjärtat bakom Keynes budskap. Knut Wicksell däremot

Quantitative structure-activity relationship (QSAR) parameters are good indicators for the reactivity of direct-acting antiviral drugs. Since molecular structure is related to molecular function, careful selection of molecular substitutions will result in more drugs that are potent. In this work, QSAR parameters are selected in order to compare the four drugs used as nucleotide inhibitors (NIs) fo

Purpose: To develop a statement on the diagnosis, classification, treatment, and rehabilitation concepts of posterolateral corner (PLC) injuries of the knee using a modified Delphi technique. Methods: A working group of three individuals generated a list of statements relating to the diagnosis, classification, treatment, and rehabilitation of PLC injuries to form the basis of an initial survey for