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In this paper, we discuss the unresolved apportionment of national debt when Ireland exited the UK in 1922. Using archival sources and contemporary accounts, we estimate that the British claim on Ireland in 1925 amounted to between 80 and 100 per cent of GNP at a time when the political stability of Ireland was already fragile. We describe the process of how this contingent liability, arising from

In the beginning of the public career of Jesus, Mark and Matthew both narrate how Jesus “calls” four fishermen to follow him which results in an immediate positive response (Mark 1:16–20/Matt 4:18–22). How is the reader to understand Jesus’ calling of disciples? Is Jesus making an authoritative command or does he merely invites the fishermen? What is Jesus doing when he “calls” his disciples? ThesIn the beginning of the public career of Jesus, Mark and Matthew both narrate how Jesus “calls” four fishermen to follow him which results in an immediate positive response (Mark 1:16–20/Matt 4:18–22). How is the reader to understand Jesus’ calling of disciples? Is Jesus making an authoritative command or does he merely invites the fishermen? What is Jesus doing when he “calls” his disciples? Thes

A contemporary trend in glacial geomorphology is the quest for a unifying theory of drumlin and ribbed moraine formation. Three Swedish example areas of each are here newly mapped, using high-resolution Light Detecting and Ranging (LiDAR) data. From previous ribbed moraine studies in these areas, we know that they formed differently, one by melt-out of stagnant debris-zonated ice, another by remou

We discuss thermal fluid-structure interaction processes, where a simulation of the time-dependent temperature field is of interest. Thereby, we consider partitioned coupling schemes with a Dirichlet-Neumann method. We present an analysis of the method on a model problem of discretized coupled linear heat equations. This shows that for large quotients in the heat conductivities, the convergence ra

Background: Levodopa-carbidopa intestinal gel (LCIG; Duodopa®) is used for continuous infusion in advanced Parkinson's disease. To achieve optimal effect, the LCIG dose is individually titrated, traditionally conducted during hospitalization in Sweden. However, dose adjustment depends on surrounding conditions, physical activity, and emotional stress, which is why titration at home could be benefi

The aim of the study was to assess the role of allogeneic stem cell transplantation (SCT) in patients diagnosed with BCR-ABL1-positive acute myeloid leukemia (AML). Fifty-seven patients (median age, 48 years, range: 19-67) with BCR-ABL1 positive AML undergoing SCT were identified. The majority of the patients (70%) received a TKI before the transplant. At SCT 48 patients were in CR (45 in CR1), wh

Background: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear. Objective: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-β 1-42 (Aβ 42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognit

18F-dopa PET measuring aromatic l-amino acid decarboxylase activity is regarded as the gold standard for evaluating dopaminergic function in Parkinson's disease. Radioligands for dopamine transporters are also used in clinical trials and for confirming PD diagnosis. Currently, it is not clear which imaging marker is more reliable for assessing clinical severity and rate of progression. The objecti

Background and purpose: Recent studies have shown that it is possible to conduct entire radiotherapy treatment planning (RTP) workflow using only MR images. This study aims to develop a generalized intensity-based method to generate synthetic CT (sCT) images from standard T2-weighted (T2w) MR images of the pelvis. Materials and methods: This study developed a generalized dual model HU conversion m

A full-term growth-restricted female newborn (1790 g), presented with lactic acidosis (12.5 mmol/L) after birth. She had renal tubulopathy, cholestasis and elevated serum ferritin concentration (2819 ng/ml). Two similarly affected sisters had died before 3 months of age. Mitochondrial disorder was suspected since the disease resembled the Finnish GRACILE syndrome, caused by a homozygous mutation (

Background: A panel of four kallikrein markers (total, free, and intact prostate-specific antigen [PSA] and human kallikrein-related peptidase 2 [hK2]) improves predictive accuracy for Gleason score ≥7 (high-grade) prostate cancer among men biopsied for elevated PSA. A four-kallikrein panel model was originally developed and validated by the Dutch center of the European Randomized Study of Screeni

Introduction: Prolonged pregnancies are associated with adverse maternal and fetal outcome. In Sweden, no national guidelines exist for when to induce prolonged pregnancies. Material and methods: Singleton cephalic prolonged pregnancies (defined as ≥ 41+3 gestational weeks) during 2001-2013 (n = 199 770) were identified using the Swedish Medical Birth Register. The maternity units were divided int