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Genetic Variants of GSK3B are Associated with Biomarkers for Alzheimer's Disease and Cognitive Function.

Background: Glycogen synthase kinase 3 beta (GSK3B) is the major kinase phosphorylating tau protein. Hyperphosphorylated tau is one of the hallmarks of Alzheimer's disease (AD). Despite extensive research, the role of GSK3B in AD pathogenesis is not fully understood. Objective: To evaluate possible associations between gene variants of GSK3B and risk of AD. Methods: Twelve GSK3B tag single-nucleot

A method for estimating effective coalescence rates during emulsification from oil transfer experiments.

The Oil Transfer Technique (OTT) was developed by Taisne et al. [1] to measure coalescence during emulsification and has been applied since in several studies. One of the main drawbacks of this technique is that it only gives a qualitative measure of coalescence. This paper proposes a new evaluation method of OTT experimental results for estimating qualitative coalescence rates, e.g. for investiga

Eating out, weight and weight gain. A cross-sectional and prospective analysis in the context of the EPIC-PANACEA study.

Objective:The aim of this study was to examine the association of body mass index (BMI) and weight gain with eating at restaurants and similar establishments or eating at work among 10 European countries of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Subjects:This study included a representative sample of 24 310 randomly selected EPIC participants.Methods:Single 2

The risk of malignancy is not increased in patients with multiple sclerosis treated with subcutaneous interferon beta-1a: analysis of data from clinical trial and post-marketing surveillance settings.

Background: Risks that are potentially associated with long-term therapies should be assessed. Objective: The present analyses were performed to determine the risk of malignancy in patients with multiple sclerosis (MS) receiving subcutaneous (sc) interferon (IFN) beta-1a, using pooled safety data from key clinical trials and data from the Merck Serono Global Drug Safety database. Methods: The stan

Visual Cryptography and Obfuscation: A Use-Case for Decrypting and Deobfuscating Information using Augmented Reality

As new technologies emerge such as wearables, it opens up for new challenges, especially related to security and privacy. One such recent technology is smart glasses. The use of glasses introduces security and privacy concerns for the general public but also for the user itself. In this paper we present ongoing theoretical work which focus on privacy of the user during authentication. We propose a

A Clinician View and Experience of Proteomic Studies in the Light of Lung Cancer in Japanese Healthcare

In Japan, rising costs have impacted the framework of maintaining an efficient and effective healthcare system. Today, urgent implementation of programs to address this need have led to a rebuilding of the entire approach of medical evaluation and clinical care. Recent developments in clinical proteomics based on mass spectrometry (MS) for identifying, sequencing, and quantifying disease-relevant

Measurement of the cross-section for W boson production in association with b-jets in pp collisions at root s=7 TeV with the ATLAS detector

This paper reports a measurement of the W+b-jets (W+b+X and W+b (b) over bar +X) production cross-section in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC. These results are based on data corresponding to an integrated luminosity of 4.6 fb(-1), collected with the ATLAS detector. Cross-sections are presented as a function of jet multiplicity and of the transverse momentum

Parity influences the severity of ACPA-negative early rheumatoid arthritis: a cohort study based on the Swedish EIRA material.

In women with rheumatoid arthritis (RA) it has been observed that during pregnancy a majority of patients experience amelioration, but after delivery a relapse of the disease is common. However, there are few studies, with diverging results, addressing the effect of parity on the severity of RA over time. Our aim was to explore the impact of parity, with stratification for anti-citrullinated prote

Composite cryogel with immobilized concanavalin A for affinity chromatography of glycoproteins.

Composite cryogels containing porous adsorbent particles were prepared under cryogelation conditions. The composites with immobilized concanavalin A (Con A) were used for capturing glycoproteins. Adsorbent particles were introduced into the structure in order to improve the capacity and to facilitate the handling of the particles. The monolithic composite cryogels were produced from suspensions of

Habitat preferences and positive assortative mating in an avian hybrid zone

The relatively narrow hybrid zone between hooded and carrion crow is characterised by a high proportion of breeding hybrids, no known intrinsic postzygotic costs, and most likely, high gene flow between populations. It is therefore of interest to identify factors preventing a breakdown of the zone. In this study, we investigate the possibility that habitat choice could create assortative mating in

Mortality and Inherited Thrombophilia: results from the European Prospective Cohort on Thrombophilia (EPCOT).

Background: Data on the survival of individuals with hereditary thrombophilia are rare and only come from retrospective studies. Objective: We aimed to assess mortality in individuals with known thrombophilia with and without a history of thrombosis in comparison to a control group. Patients/Methods: The European Prospective Cohort on Thrombophilia (EPCOT) study is a prospective multi-centre obser

The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.

The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.

Innovation in the Public Procurement Process: A study of the creation of innovation-friendly public procurement.

Public sector organizations are large buyers and in previous research public sector has been regarded to be able to affect the market through demand driven innovation, especially if different public sector entities collaborate with each other. However, what this study shows is that it is not necessary to be big or to collaborate in order to make an impact on the market, even smaller local authorit

POSITIONAL CONCERNS IN AN OLG MODEL OPTIMAL LABOR AND CAPITAL INCOME TAXATION

This article concerns optimal income taxation under asymmetric information in a two type OLG model when indi viduals relative consumption matters Positional concerns affect the policy choices via two channels (i) the average degree of positionality and (ii) positionality differences between the low ability type and the mimicker Under plausible empirical estimates the marginal labor income tax rate