This paper reports the findings of a global survey of practice patterns for the management of patients with haemophilia A. A total of 147 haemophilia treatment centres worldwide responded to the questionnaire, supplying data for 16 115 patients with haemophilia A. From these responses, 38% (range: 25-48%) of patients were under 18 years old. Almost half (47%) of patients were reported to have mild

Angiogenesis occurs in the brains of Parkinson's disease patients, but the effects of dopamine replacement therapy on this process have not been examined. Using rats with 6-hydroxydopamine lesions, we have compared angiogenic responses induced in the basal ganglia by chronic treatment with either L-DOPA, or bromocriptine, or a selective D1 receptor agonist (SKF38393). Moreover, we have asked wheth

LOV (light-oxygen-voltoge-sensitive) domains comprise the lightsensitive parts of many blue light photoreceptor proteins. Photoexcitation of the chromophore flavin mononucleotide (FMN) in these LOV domains leads to formation of a covalent adduct between FMN and a cysteine residue. So for, the electronically excited singlet and triplet states of FMN have been identified as the only intermediates in

In the present study, expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in rat dorsal root ganglion (DRG) neurons and sciatic nerve following experimental sciatic nerve compression was studied with the use of quantitative immunohistochemistry and in situ hybridization. Previously, we have investigated changes in PACAP expression after nerve transection and, here, the far mor

Primary infection by group A streptococci (GAS) takes place at either the throat or skin of the human host, often leading to pharyngitis or impetigo, respectively. Many GAS strains differ in their preference for throat and skin tissue sites. Previous epidemiological findings show that many of the strains displaying strong tropism for the skin have a high-affinity binding site for plasminogen, loca

The effect of rapid lowering of blood glucose on cerebral blood flow (CBF) was studied in 10 Type 1 (insulin-dependent) diabetic patients (age 23.5 ± 3.8 years; mean ± S.D.) with longstanding, poor metabolic control (HbA1c 11.2 ± 1.0%; normal value 4.0–5.3%) using an intravenous xenon 133 single photon emission computed tomography technique. After a fall in blood glucose, during 81 ± 11 min (mean

Patients with multiple myeloma ( MM) have an increased risk of deep venous thrombosis (DVT), particularly when treated with immunomodulatory drugs. Recently, 2 small hospital-based studies observed persons with the MM precursor condition, monoclonal gammopathy of undetermined significance (MGUS), to be at increased risk of developing DVT. Among 4 196 197 veterans hospitalized at least once at US V

The nexus of international cooperation and international organization is the focus of this article. It proceeds from a critique of extant approaches. Specifically, the relative negligence of organization theory in the study of international organization and the overreliance on structural theories in the study of international cooperation are noted. An interorganizational perspective is proffered a

Incubation was for a long time considered to be a period of decreased activity and low cost for parents. It was therefore ignored as a potential factor affecting life-history trade-offs in birds. Lately this view has started to change, and studies now show that there might be considerable costs connected to incubation. We experimentally reduced the nest temperature during incubation in blue tits C

Mutations that cause a block in a late step of the protoheme IX biosynthetic pathway, i.e., in a step after uroporphyrinogen III, map at 94 degrees on the Bacillus subtilis chromosomal genetic map. We have cloned and sequenced the hem genes at this location. The sequenced region contains six open reading frames: ponA, hemE, hemH, hemY, ORFA, and ORFB. The ponA gene product shows over 30% sequence

Health risks associated with exposure to airborne particulate matter (PM) have been shown epidemiologically as well as experimentally, pointing to both respiratory and cardiovascular effects. These health risks are of increasing concern in society, and to protect public health, a clarification of the toxic properties of particles from different sources is of importance. Lately, wear particles gene

Recent work identifies two kinases required for phosphorylation of proteins of chloroplast thylakoid membranes. One kinase, STN7, is required for phosphorylation of light-harvesting complex II; another, STN8, is required for phosphorylation of photosystem II. How do these kinases interact, what do they do, and what are they for?

Purpose: To describe a technique that facilitates the safe introduction of aortic stent-grafts through diseased iliac arteries. Technique: The technique involves relining and dilating ("paving and cracking") stenosed iliac arteries with covered stents prior to the introduction of the main aortic stent-graft. It has been successfully used to introduce aortic stent-grafts in patients where other tra