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Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain

Aims: According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons. Methods:

How learning spaces matter in entrepreneurship education : introducing the concept of topopraxis

Research into entrepreneurship education has explored content, audience and pedagogy but much is still to be studied when it comes to the spatial dimensions of learning–that is, where entrepreneurship is taught, how this matters for pedagogies used, and the implications for learning. We seek to strengthen a theoretical foundation for understanding learning spaces and the spatial dimensions in entr

Organizational and Institutional Entrepreneuring : Introduction to the Special Issue

In our Introduction to this Special Issue on Organizational and Institutional Entrepreneuring, we draw attention to the importance of recognizing how processes and practices of entrepreneuring take place in the context of an already organized world. We particularly draw attention to how such entrepreneuring processes, as imaginative-poetic extensions beyond the present, can occur in a variety of s

Stirring and disturb - urging the movement of academic entrepreneurship onwards

In an epilogue, Daniel Hjorth and Chris Steyaert aim to further multiply the new movements in academic entrepreneurship that this volume identifies. Therefore, they introduce a conceptual quartet that makes and keeps movement going: provocation, mobilization, affirmation, and experimentation. Their conceptual contribution, which has to be seen as an attempt to stir and disturb, relates these four

Entrepreneurial intermediation in innovation : A study of multilayered contexts and embedded dynamics of organisation-creation

The article is based on a theoretical exploration and empirical analysis of formalized public initiated instruments—eight network entrepreneurs—intended to promote, intermediate and support innovation and entrepreneurship in firms and firm networks located in three different business areas in Mid-Norway: food value chain, experience industries, and renewable energy and environmental technology. Th

6-bromoindirubin-3’-oxime promotes osteogenic differentiation of canine BMSCs through inhibition of GSK3β activity and activation of the Wnt/β-catenin signaling pathway

This study aimed to investigate how 6-bromoindirubin-3’-oxime (BIO) increases the osteogenic differentiation of canine bone mesenchymal stem cells (BMSCs) and the role of the Wnt/β-catenin signaling pathway in this process. We mimicked the effect of Wnt by adding BIO to the culture medium of BMSCs and examined whether canonical Wnt signaling positively affects the differentiation of these cells in

Tryptophan and kynurenine stimulate human decidualization via activating Aryl hydrocarbon receptor : Short title: Kynurenine action on human decidualization

Decidualization is essential for successful pregnancy in rodents and primates. Although L-Tryptophan and its metabolites are essential for mammalian pregnancy, the underlying mechanism is poorly defined. We explored effects of tryptophan and kynurenine on human in vitro decidualization in human endometrial stromal cell line and primary endometrial stromal cells. Tryptophan significantly stimulates

Regulation and function of laminin A5 during mouse and human decidualization

Decidualization is essential to the establishment of pregnancy in rodents and primates. Laminin A5 (encoding by Laminin α5) is a member of the laminin family, which is mainly expressed in the basement membranes. Although laminins regulate cellular phenotype maintenance, adhe-sion, migration, growth, and differentiation, the expression, function, and regulation of laminin A5 during early pregnancy

The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization

Introduction: High-mobility group box 1 (HMGB1) is a non-histone nuclear protein and can be extracellularly secreted to induce sterile inflammation. Although uterine deletion of HMGB1 causes implantation and decidualization defects, how secreted HMGB1 is involved in mouse early pregnancy is still unknown. Methods: Mouse models, mouse primary endometrial cells and human endometrial cell lines were

Multi-template analysis of human perirhinal cortex in brain MRI : Explicitly accounting for anatomical variability

RATIONAL: The human perirhinal cortex (PRC) plays critical roles in episodic and semantic memory and visual perception. The PRC consists of Brodmann areas 35 and 36 (BA35, BA36). In Alzheimer's disease (AD), BA35 is the first cortical site affected by neurofibrillary tangle pathology, which is closely linked to neural injury in AD. Large anatomical variability, manifested in the form of different

Expression and Regulation of a Novel Decidual Cells-Derived Estrogen Target during Decidualization

During decidualization in rodents, uterine stromal cells undergo extensive reprogramming to differentiate into distinct cell types, forming primary decidual zones (PDZs), secondary decidual zones (SDZs), and layers of undifferentiated stromal cells. The formation of secondary decidual zones is accompanied by extensive angiogenesis. During early pregnancy, besides ovarian estrogen, de novo synthesi

Comparison of In Vivo and Ex Vivo MRI of the Human Hippocampal Formation in the Same Subjects

Multiple techniques for quantification of hippocampal subfields from in vivo MRI have been proposed. Linking in vivo MRI to the underlying histology can help validate and improve these techniques. High-resolution ex vivo MRI can provide an intermediate modality to map information between these very different imaging modalities. This article evaluates the ability to match information between in viv

Molecular Mechanism of Mouse Uterine Smooth Muscle Regulation on Embryo Implantation

Myometrium plays critical roles in multiple processes such as embryo spacing through peristalsis during mouse implantation, indicating vital roles of smooth muscle in the successful establishment and quality of implantation. Actin, a key element of cytoskeleton structure, plays an important role in the movement and contraction of smooth muscle cells (SMCs). However, the function of peri-implantati

Female reproductive abnormalities in mouse adolescent pregnancy

There are around 300 million adolescent pregnancies worldwide, accounting for 11% of all births worldwide. Accumulating evidence demonstrates that many adverse perinatal outcomes are associated with adolescent pregnancies. However, how and why these abnormalities occur remain to be defined. In this study, pregnancy at different stages was compared between 25- and 30- day-old and mature female mice

Blastocyst-induced ATP release from luminal epithelial cells initiates decidualization through the P2Y2 receptor in mice

Embryo implantation involves a sterile inflammatory reaction that is required for the invasion of the blastocyst into the decidua. Adenosine triphosphate (ATP) released from stressed or injured cells acts as an important signaling molecule to regulate many key physiological events, including sterile inflammation. We found that the amount of ATP in the uterine luminal fluid of mice increased during

Aldosterone from endometrial glands is benefit for human decidualization

Local renin-angiotensin system (RAS) in female reproductive system is involved in many physiological and pathological processes, such as follicular development, ovarian angiogenesis, ovarian, and endometrial cancer progress. However, studies on the functional relevance of RAS in human endometrium are limited, especially for renin-angiotensin-aldosterone system (RAAS). In this study, we defined the

Resveratrol promotes osteogenic differentiation of canine bone marrow mesenchymal stem cells through wnt/beta-catenin signaling pathway

Bone marrow mesenchymal stem cells (BMSCs) can transdifferentiate into different types of cells and may serve as a cell source for tissue engineering. Resveratrol has been shown to possess many benefits, including activation of osteogenesis. Furthermore, Wnt/β-catenin signaling has been known to promote osteogenic differentiation in many cells. In this study, we investigated the role of resveratro

G protein-coupled estrogen receptor 1 inhibits the epithelial–mesenchymal transition of goat mammary epithelial cells via NF-κB signalling pathway

Mastitis is one of the most frequent clinical diseases in dairy animals. Epithelial cells undergoing epithelial–mesenchymal transition (EMT) promote the process of mastitis. Oestrogen deficiency is disadvantaged of many tissue inflammation and regeneration, while exogenous oestrogen treatment can reverse these effects. G protein-coupled estrogen receptor 1 (GPER1) is a membrane estrogen receptor.

Clinical Characteristics Suggestive of a Genetic Cause in Cerebral Palsy : A Systematic Review

BACKGROUND: Cerebral palsy (CP) is a clinical diagnosis and was long categorized as an acquired disorder, but more and more genetic etiologies are being identified. This review aims to identify the clinical characteristics that are associated with genetic CP to aid clinicians in selecting candidates for genetic testing.METHODS: The PubMed database was systematically searched to identify genes asso

Hippocampal disconnection in early Alzheimer's disease : a 7 tesla MRI study

BACKGROUND: In patients with Alzheimer's disease (AD), atrophy of the entorhinal cortex (ERC) and hippocampal formation may induce degeneration of connecting white matter tracts.OBJECTIVE: We examined the association of hippocampal subfield and ERC atrophy at 7 tesla MRI with fornix and parahippocampal cingulum (PHC) microstructure in patients with early AD.METHODS: Twenty-five patients with amnes