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Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the HTT gene. This leads to progressive loss of striatal neurons and motor-cognitive decline. While current gene-targeting approaches aiming at reducing somatic instability show promise – especially in case of early treatment – they cannot restore the already compromised neuronal circuitry at advanc

Context In most cases of non-islet cell tumor hypoglycemia (NICTH), high molecular weight forms of insulin-like growth factor II, commonly referred to as big IGF-II, cause hypoglycemia. MicroRNA-483 (miR-483), encoded within an intron of IGF2, has been suggested to be coexpressed with IGF-II. Objective The aim of this study is to demonstrate the utility and reliability of circulating miR-483 as a

Konstantin den stores liv var dramatiskt som få. Född under osäkra omständigheter, så att vi inte ens kan säga vilket år han föddes, klättrade han till makten i början av 300-talet. I en tid då romerska kejsare inte blev långlivade skulle han regera längst av alla, i över trettio år, och under den tiden skrev han om historien. På vägen såg han visioner, erövrade han Rom, mördade han sin hustru och

Background: Systematic analyses of global health trends can provide an accurate narrative of progress and challenges. We analysed the impact of changing age-specific mortality (epidemiology) and age structure (demography) on crude death rates (CDRs) and causes of death with large or rising mortality to inform the third Lancet Commission on Investing in Health. Methods: Data from the World Populati

Giant number fluctuations (GNFs), whereby the standard deviation ΔN in the local number of particles ⟨N⟩ grows faster than sqrt[⟨N⟩], are a hallmark property of dry active matter systems with orientational order, such as a collection of granular particles on a vibrated plate. This contrasts with momentum-conserving ("wet") active matter systems, such as suspensions of swimming bacteria, where no t

We study the electronic structure of bulk 1T-TaSe_{2} in the charge-density wave phase at low temperature. Our spatially and angle-resolved photoemission data show insulating areas coexisting with metallic regions characterized by a chiral Fermi surface and moderately correlated quasiparticle bands. Additionally, high-resolution laser angle-resolved photoemission reveals variations in the metallic

Background: Previous studies suggest an antidepressant effect of omega-3 fatty acids (n-3 PUFAs). This effect may be larger in patients with low-grade inflammation, defined as mild elevations of high sensitivity C-reactive protein or other commonly used inflammatory markers. The antidepressant mechanisms of n-3 PUFAs are not fully understood but may involve modulation of immunometabolic processes

Proper arterial versus venous endothelial lineage identity is required to establish a hierarchical network of arteries and veins and prevent the occurrence of life-threatening arteriovenous malformations. The molecular mechanisms that govern arteriovenous lineage specification remain however incompletely understood. Here, we demonstrate that the transcription factor Prdm16 is expressed in arterial

OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Research objective 1: to assess the effects of different oxygen saturation targets for the delivery room resuscitation of preterm infants. Research objective 2: to assess the effects of different titration strategies for the delivery room resuscitation of preterm infants.

Deep eutectic solvents (DESs) are often promoted as a more environmentally friendly alternative for ionic liquids and other ionic solvents. Like ionic liquids, DESs can be designed for specific tasks in various chemical environments, but their usage in extraction processes is often significantly hampered by difficulties in recovering the extraction product. To remedy this, various tactics are bein

A general formulation for the distribution problem is presented, which is applicable to frequency distributions of subgrid-scale variables and hydrometeor size distributions, as well as to probability distributions characterizing data uncertainties. The general formulation is presented based upon two well-known basic principles: the maximum-entropy principle and the Liouville equation. The maximum

Background T-cell activation and clonal expansion are essential to effective immunotherapy responses in non-small cell lung cancer (NSCLC). The distribution of T-cell clones may offer insights into immunogenic mechanisms and imply potential prognostic and predictive information. Methods We analyzed α/β T-cell receptor (TCR) clonality using RNA-sequencing of bulk frozen tumor tissue from 182 patien

Self-care interventions for sexual and reproductive health (SRH), including HIV self-testing, self-injected contraception and self-managed abortion, offer promising pathways to advance universal health coverage, particularly in low- and middle-income countries. While often framed as cost-saving measures, this paper argues that self-care should be understood as a strategic investment in health syst

The dynamics of atmospheric CO2 concentrations during and following the last deglaciation have mainly been ascribed to carbon release from and uptake in oceans, primarily in the Southern Ocean. But recent studies also point toward a terrestrial influence. We quantify dynamic changes to northern terrestrial carbon stocks from the Last Glacial Maximum (21,000 years) until present at millennial time

Introduction Neoadjuvant therapy is the standard of care for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Studies on first-generation antibody-drug conjugates, such as trastuzumab emtansine (T-DM1), showed equal or slightly lower efficacy than chemotherapy combined with dual HER2 blockade. Trastuzumab deruxtecan (T-DXd) is a next-generation conjugat

Denna studie undersöker hur chefer använder lyssnande som ett verktyg i konflikthantering och hur detta påverkar relationer, arbetsmiljö och värdeskapande i organisationer. Genom en kvalitativ metod med tio semistrukturerade intervjuer med chefer från olika branscher har forskarna analyserat hur lyssnande praktiseras i kommunikativa processer vid konflikter. Studien baseras på teorier om lyssnande

Fraktaler är mängder som har detaljer på varje skala. För många sådana mängder är mått som area och längd inte tillräckligt som en beskrivning av storlek. Ta exempelvis den inverterade Koch-kurvan. Kurvan skapas genom att vi tar bort mittdelen av varje sidlängd i omkretesen av en triangel och byter ut den med de andra två sidorna av en liksidig triangel baserat på denna mittdel. Upprepar vi dennaThe purpose of this thesis is to cover the definition and basic properties of the Hausdorff measure and treat the proofs of Davies and Cordoba of the Kakeya conjecture in R^2. The conjecture states that any compact set in R^2 containing a line in every direction has Hausdorff dimension 2. Using mainly basic measure theory we construct the Hausdorff measure and develop relevant theorems, such as Ma