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Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4.

Next generation sequencing of uveal melanoma (UM) samples has identified a number of recurrent oncogenic or loss-of-function mutations in key driver genes including: GNAQ, GNA11, EIF1AX, SF3B1 and BAP1. To search for additional driver mutations in this tumor type we carried out whole-genome or whole-exome sequencing of 28 tumors or primary cell lines. These samples have a low mutation burden, with

EU-gruppundantag med förhinder

Artikel presenterar det nya förslaget till gruppundantag för tekniklicensavtal och granskar om kommissionen lyckas i sitt uppsåt att främja och förenkla tekniksamverkan i Europa. Dagens rättsläge diskuteras i avsnitt II. I avsnitt III presenteras det senaste förslaget översiktligt och därefter behandlas det nya marknadsandelsförslaget. I avsnitt V kommenteras hanteringen av marknadsuppdelning och

Construct validity of a health questionnaire intended to measure the subjective experience of health among patients in mental health services.

Mental health services have been lacking systematic health-promoting activities, and health is often perceived as the absence of disease from a biomedical perspective. It is vital to develop methods to assess perceived health among patients in a broader perspective. The aim of the study was to investigate construct validity of a newly developed health questionnaire intended to measure subjectively

Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.

Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than O

Receptive Field Remodeling Induced by Skin Stimulation in Cerebellar Neurons in vivo.

The receptive field of a neuron reflects its function. For example, for parallel fiber (PF) inputs in C3 zone the cerebellar cortex, the excitatory and inhibitory receptive fields of a Purkinje cell (PC) have different locations, and each location has a specific relationship to the location of the climbing fiber (CF) receptive field of the PC. Previous studies have shown that this pattern of input

Thylakoids promote release of the satiety hormone cholecystokinin while reducing insulin in healthy humans.

Objective. The effects of a promising new appetite suppressor named "thylakoids" (membrane proteins derived from spinach leaves) were examined in a single meal in man. Thylakoids inhibit the lipase/colipase hydrolysis of triacylglycerols in vitro and suppress food intake, decrease body-weight gain and raise the satiety hormone cholecystokinin (CCK) in rats, but their effects in man remain unclear.

Roflumilast increases bacterial load and dissemination in a model of Pseudomononas aeruginosa airway infection

Exacerbations present a major clinical problem in many patients suffering from COPD. Roflumilast, an inhibitor of phosphodiesterase 4, has beneficial effects in several clinical trials and is currently widely used to prevent exacerbations in severe COPD. Roflumilast has anti-inflammatory properties that may interfere with potentially important host defense functions, including cytotoxic properties

RIFM fragrance ingredient safety assessment, Fenchyl alcohol, CAS registry number 1632-73-1.

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exp