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The 1501 Ma Kuonamka Large Igneous Province of northern Siberia : U-Pb geochronology, geochemistry, and links with coeval magmatism on other crustal blocks

A new large igneous province (LIP), the 1501 ± 3 Ma Kuonamka LIP, extends across 700 km of northern Siberia and is linked with coeval dikes and sills in the formerly attached Sao Francisco craton (SFC)-Congo craton to yield a short-duration event 2000 km across. The age of the Kuonamka LIP can be summarized as 1501 ± 3 Ma (95% confidence), based on 7 U-Pb ID-TIMS ages (6 new herein) from dolerite

Empathy, engagement, entrainment : The interaction dynamics of aesthetic experience

Empathy concerns the feeling of understanding others’ experiences from their perspective, and confronts you with the presence of a qualitative experience that you are not living through yourself. In aesthetics empathy has been conceived as bodily inner imitation. Taking a theoretical, interdisciplinary approach that merges insights from psychology, philosophy, and phenomenology within the dynamic

Runaway gas accretion and gap opening versus type I migration

Growing planets interact with their natal protoplanetary disc, which exerts a torque onto them allowing them to migrate in the disc. Small mass planets do not affect the gas profile and migrate in the fast type-I migration. Although type-I migration can be directed outwards for planets smaller than 20−30M⊕ in some regions of the disc, planets above this mass should be lost into the central star lo

The importance of the molecular weight of ethyl cellulose on the properties of aqueous-based controlled release coatings

Previous investigations of aqueous based ethyl cellulose (EC) latex dispersions have mainly focused on the commercially available viscosity grade 20 cps. In this study, dispersions of EC with varying viscosity grades (which correspond to molecular weights), ranging from 4 to 100 cps, were produced and characterised. The dispersions showed particle sizes around 200 nm and highly negative ζ-potentia

Evolution of In-Cylinder Diesel Engine Soot and Emission Characteristics Investigated with Online Aerosol Mass Spectrometry

To design diesel engines with low environmental impact, it is important to link health and climate-relevant soot (black carbon) emission characteristics to specific combustion conditions. The in-cylinder evolution of soot properties over the combustion cycle and as a function of exhaust gas recirculation (EGR) was investigated in a modern heavy-duty diesel engine. A novel combination of a fast gas

Facile synthesis of novel soluble cellulose-grafted hyperbranched polymers as potential natural antimicrobial materials

A new class of soluble cellulose-grafted hyperbranched polymers has been synthesized by a facile “hypergrafting” reaction using bis(2-chloroethyl)amine and soluble cellulose tosylates. The molecular structures of the obtained new materials were characterized by 13C NMR, FTIR spectroscopy, and elemental analysis. The degree of substitution of the hyperbranched cellulose derivatives ranges between 0

Servicescapes seen by visually impaired travellers : Time-geography approach to servicescape research

Kunskapsluckor kvar i studien av servicescapes, eftersom befintlig forskning på servicescapes tenderar att ignorera stora framsteg i förståelsen av tid och rum som sociala fenomen. En aspekt som särskilt kräver ytterligare studier är hur nya begränsningar påverkar kundernas interaktioner med organiserade serviceplatser. Tidsgeografi tillvägagångssätt därför tillämpas på nuvarande servicescape forsKnowledge gaps remain in the study of servicescapes, since existing research on servicescapes tends to ignore major advances in the understanding of space and time as social phenomena. One aspect that particularly requires further study is how emerging constraints influence customers’ interactions with organized service places. The time-geography approach was therefore applied to the current servi

Prevention and management of foot problems in diabetes : A Summary Guidance for Daily Practice 2015, based on the IWGDF guidance documents

Foot problems complicating diabetes are a source of major patient suffering and societal costs. To prevent, or at least reduce, the adverse effects of foot problems in diabetes, the International Working Group on the Diabetic Foot (IWGDF; www.iwgdf.org) was founded in 1996, consisting of experts from almost all the disciplines involved in the care of patients with diabetes and foot problems. An im

Dependence of the Calvin cycle activity on kinetic parameters for the interaction of non‐equilibrium cycle enzymes with their substrates

Kinetic model studies and control analyses of the Calvin photosynthesis cycle have been performed to characterize the dependence of the cycle activity on maximum velocities and Kmvalues for the interaction of the non‐equilibrium cycle enzymes and ATP synthetase with their substrates under conditions of light and carbon dioxide saturation. The results show that Km values have no major influence on

Carboxylate binding modes in zinc proteins : A theoretical study

The relative energies of different coordination modes (bidentate, monodentate, syn, and anti) of a carboxylate group bound to a zinc ion have been studied by the density functional method B3LYP with large basis sets on realistic models of the active site of several zinc proteins. In positively charged four-coordinate complexes, the mono- and bidentate coordination modes have almost the same energy

Foreign Institutional Investment, Ownership, and Liquidity : Real and Informational Frictions

The literature widely documents the negative liquidity impact of foreign participation in firms that permit high foreign institutional ownership. This paper employs a unique setting for the limited participation of qualified foreign institutional investors (QFIIs) in China's A-share market and examines how this impacts on stock liquidity in emerging markets. Contrary to the findings in the literat

Enzalutamide in Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer : Extended Analysis of the Phase 3 PREVAIL Study

Enzalutamide significantly improved radiographic progression-free survival (rPFS) and overall survival (OS) among men with chemotherapy-naïve metastatic castration-resistant prostate cancer at the prespecified interim analysis of PREVAIL, a phase 3, double-blind, randomized study. We evaluated the longer-term efficacy and safety of enzalutamide up to the prespecified number of deaths in the final

Short-term outcome after total hip arthroplasty using dual-mobility cup : report from Lithuanian Arthroplasty Register

Purpose: The purpose of the study was to investigate how the use of dual-mobility cups (DMCs) affected the risk of revision due to dislocation as well as overall risk of revision compared with a conventional total hip arthroplasty (THA) system in the short term. Methods: A total of 12,657 primary THAs were registered from the start of 2011 to the end of 2014. 620 THAs were with DMCs. For compariso

Cystatin C as a Multifaceted Biomarker in Kidney Disease and Its Role in Defining "Shrunken Pore Syndrome"

Cystatin C, a basic nonglycosylated 13.3 kDa protein comprising a single polypeptide chain of 120 amino acid residues, is produced at a stable rate from a housekeeping gene in all nucleated cells and eliminated from the circulation by free filtration through the glomerular membranes as described in the first edition of "Biomarkers of Kidney Disease." This discourse will report some of the progress

Improvement of energy resolution of ΔE-E CsI/SSD- telescope at measurement of (γ,p)-Reactions using strip information of SSD

Information on the triggered strips of silicon strip detectors of a MAX-lab ΔE-E CsI/SSD-telescope was used to determination the angular range of emitted reaction particles. It allowed an improvement in the energy resolution of the telescope by decreasing the kinematical broadening of the missing energy spectra of12C(γ,p)11B reaction, and enabling more accurate separation of exited states of resid

Visual navigation in nocturnal insects

Despite their tiny eyes and brains, nocturnal insects have evolved a remarkable capacity to visually navigate at night. Whereas some use moonlight or the stars as celestial compass cues to maintain a straight-line course, others use visual landmarks to navigate to and from their nest. These impressive abilities rely on highly sensitive compound eyes and specialized visual processing strategies in

Expression of STAT3 in Prostate Cancer Metastases

STAT3 and its upstream activator IL6R have been implicated in the progression of prostate cancer and are possible future therapeutic targets. We analyzed 223 metastatic samples from rapid autopsies of 71 patients who had died of castration-resistant prostate cancer (CRPC) to study protein and gene expression of pSTAT3 and IL6R. Immunohistochemical analysis revealed that 95% of metastases were posi

Peak-to-valley ratios for three different HPGe detectors for the assessment of 137Cs deposition on the ground and the impact of the detector field-of-view

The peak-to-valley (PTV) method was investigated experimentally comparing PTV ratios for three HPGe detectors, with complementary Monte Carlo simulations of scatter in air for larger source-detector distances. The measured PTV ratios for 137Cs in air were similar for three different detectors for incident angles between 0 and 90°. The study indicated that the PTV method can differentiate between s

Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver

Aim: To study the impact of aging on DNA methylation and mRNA expression in human liver. Experimental procedures: We analysed genome-wide DNA methylation and gene expression in human liver samples using Illumina 450K and HumanHT12 expression BeadChip arrays. Results: DNA methylation analysis of ∼455,000 CpG sites in human liver revealed that age was significantly associated with altered DNA methyl